scholarly journals Studies on the Metabolic Fate of Flecainide Acetate. (1). Blood Levels, Distribution, Metabolism and Excretion in Rats after Repeated Intravenous Administration.

1999 ◽  
Vol 14 (3) ◽  
pp. 201-213
Author(s):  
Mannen MISHIMA ◽  
Masataka UEDA ◽  
Atsushi TAKAO ◽  
Atsuhiro INABA ◽  
Keiko KAMIYA ◽  
...  
Keyword(s):  
Intravenous Administration ◽  
Blood Levels ◽  
Metabolic Fate ◽  
Flecainide Acetate

Dr. Shannon Replies

PEDIATRICS ◽  
1975 ◽  
Vol 56 (4) ◽  
pp. 619-619
Author(s):  
Daniel C. Shannon
Keyword(s):  
Gastrointestinal Tract ◽  
Side Effects ◽  
Intravenous Administration ◽  
Ductus Arteriosus ◽  
Oral Feeding ◽  
Blood Levels ◽  
Severe Toxicity ◽  
Potential Toxicity ◽  
Nasojejunal Tube ◽  
Rectal Route

Dr. Morens raises questions of potential toxicity of theophylline in the gastrointestinal tract, kidney and ductus arteriosus. Except for vomiting, which has occurred in some infants when blood levels have been excessive (mainly 2Oµg/ml), we have not observed any of these side effects in treating 93 infants. In all infants, treatment was given through a nasogastric or nasojejunal tube until oral feeding was possible. Because acute severe toxicity in children and adults has been related to intravenous administration, we have used this route only when necessary. Because of erratic absorption, we have avoided the rectal route.

scholarly journals Metabolic fate of KRN8601: Plasma level, distribution, metabolism and excretion of 125I-KRN8601 after a single intravenous administration to rats.

1990 ◽  
Vol 5 (3) ◽  
pp. 283-305
Author(s):  
Tadashi MISAIZU ◽  
Hiroshi SHINKAI ◽  
Hideji TANAKA ◽  
Masumi TANIMOTO ◽  
Hideaki TAKAHASHI ◽  
...  
Keyword(s):  
Plasma Level ◽  
Intravenous Administration ◽  
Metabolic Fate ◽  
Single Intravenous Administration
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