scholarly journals In Solitary Rabbits, Does the Presence or Absence of a Mirror Affect Stress, Fear and Anxiety?

2019 ◽  
Vol 4 (2) ◽  
Author(s):  
Rebecca Schofield
Keyword(s):  
Open Access ◽  
Environmental Enrichment ◽  
Current Level ◽  
Psychological Effects ◽  
Controlled Trials ◽  
Bottom Line ◽  
Level Of Knowledge ◽  
Fear And Anxiety ◽  
Positive Effect ◽  
Insight Into

<strong>PICO question</strong><br /><p>In solitary rabbits, does the presence or absence of a mirror affect stress, fear and anxiety?</p><strong>Clinical bottom line</strong><br /><p>Four studies were reviewed in this knowledge summary. Despite the small number of papers available, the controlled trials and their methodologies provide strong evidence that the behavior of solitary laboratory rabbits is affected by the presence or absence of mirrors. This evidence also indicates an effect on their welfare.</p><p>The studies suggest that the presence of mirrors provides environmental enrichment and have a positive effect on the subjects health and welfare. However, it is also suggested that mirrors may have some detrimental physical and psychological effects for some individuals. There are also many gaps in the available research and these need to be addressed to give better insight into the effect of mirrors on rabbits.</p><p>Because of the current level of knowledge, clinical recommendations cannot be made at present on the use of mirrors in solitary rabbits to improve their veterinary care whilst hospitalised.</p><br /> <img src="https://www.veterinaryevidence.org/rcvskmod/icons/oa-icon.jpg" alt="Open Access" /> <img src="https://www.veterinaryevidence.org/rcvskmod/icons/pr-icon.jpg" alt="Peer Reviewed" />

scholarly journals Are Pressure Vests Beneficial at Reducing Stress in Anxious and Fearful Dogs?

2018 ◽  
Vol 3 (1) ◽  
Author(s):  
Louise Anne Buckley
Keyword(s):  
Open Access ◽  
Beneficial Effect ◽  
Data File ◽  
Bottom Line ◽  
Beneficial Effects ◽  
Subjective Assessments ◽  
Anxiety Levels ◽  
Reducing Stress ◽  
Positive Effect ◽  
Variable Quality

<strong>PICO question</strong><br /><p>In fearful or anxious dogs does wearing a pressure vest, compared to not wearing one, result in reduced behavioural and physiological signs of stress? </p><strong>Clinical bottom line</strong><br /><p>Four studies of variable quality and limitations were identified that investigated the use of pressure vests, using various physiological and behavioural proxy measures of anxiety. Most behavioural outcome measures associated with a positive effect were subjective assessments, with unblinded assessors. Subjectively, many of the owners believed that pressure vests had a positive effect on their dogs’ anxiety levels.</p><p>The take home message for the veterinary professional is that pressure vests may have small but beneficial effects on canine anxiety and that habituating the dog to the vest, assessing for comfort and using repeatedly may improve the likelihood of any benefit. However, the owner should be cautioned that they should not expect their dog’s anxiety to be fully alleviated or prevented, and it may have no beneficial effect at all. </p><a href="https://ctt.ec/XrfoM" target="_blank"><img style="border: 0px none; width: 79px; height: 33px; margin: 0px; float: left; outline: none; text-decoration: none; -ms-interpolation-mode: bicubic;" src="https://gallery.mailchimp.com/d225a799e9a6edf193d7484f0/images/e989acbf-a9e8-41d9-ade3-1c24637fcbdd.png" alt="" width="79" height="33" data-file-id="2781617" /></a><p><img src="https://www.veterinaryevidence.org/rcvskmod/icons/oa-icon.jpg" alt="Open Access" /> <img src="https://www.veterinaryevidence.org/rcvskmod/icons/pr-icon.jpg" alt="Peer Reviewed" /></p>

scholarly journals Миокины

2020 ◽  
Author(s):  
A.A. Paltsyn
Keyword(s):  
Current Level ◽  
The Body ◽  
Target Cells ◽  
Low Molecular Weight ◽  
Specific Task ◽  
Deep Insight ◽  
Endocrine Effects ◽  
Medical Practices ◽  
Level Of Knowledge ◽  
Insight Into

Миокины - небольшие по массе пептиды, которые образуются, экспрессируются на поверхности и выделяются в кровоток мышечными волокнами. Оказывают аутокринное, паракринное и эндокринное действие, прежде всего на мышцы. Значение миокинов для медицины определяется тем, что мышцы самая крупная часть тела по массе и объему, что обеспечивает первую и главную для жизни функцию - движение. Все патологические процессы протекают с нарушением образования, распределения и взаимодействия миокинов с клетками - мишенями. Детализация этих процессов - тема большая и сложная. Тем не менее, уже на современном уровне знаний ориентированные на миокины медицинские практики могут быть вполне эффективны, поскольку основа их - модифицированная под конкретную задачу разумная физическая активность.Myokines are low-molecular-weight peptides that are formed, expressed on the surface, and secreted into the bloodstream by muscle fibers. They have autocrine, paracrine and endocrine effects, especially on muscles. Significance of myokines for medicine is determined by the fact that muscles are the largest part of the body by their mass and volume and provide the first and the most vitally important function, the movement. All pathological processes are associated with violations of myokine formation, distribution, and interaction with target cells. Providing a deep insight into these processes is a big and complex topic. Nevertheless, at the current level of knowledge, myokine-oriented medical practices can be quite effective since these practices are based on reasonable physical activity adjusted to a specific task.

scholarly journals The Vitreous Ecosystem in Diabetic Retinopathy: Insight into the Patho-Mechanisms of Disease

2021 ◽  
Vol 22 (13) ◽  
pp. 7142
Author(s):  
Siva S.R. Iyer ◽  
Mollie K. Lagrew ◽  
Stephanie M. Tillit ◽  
Ramak Roohipourmoallai ◽  
Samuel Korntner
Keyword(s):  
Diabetic Retinopathy ◽  
Growth Factors ◽  
Molecular Level ◽  
Vitreous Humor ◽  
Current Level ◽  
Significant Progress ◽  
The World ◽  
Level Of Knowledge ◽  
Insight Into

Diabetic retinopathy is one of the leading causes of blindness in the world with the incidence of disease ever-increasing worldwide. The vitreous humor represents an extensive and complex interactive arena for cytokines in the diabetic eye. In recent decades, there has been significant progress in understanding this environment and its implications in disease pathophysiology. In this review, we investigate the vitreous ecosystem in diabetic retinopathy at the molecular level. Areas of concentration include: the current level of knowledge of growth factors, cytokine and chemokine mediators, and lipid-derived metabolites in the vitreous. We discuss the molecular patho-mechanisms of diabetic retinopathy based upon current vitreous research.

scholarly journals In Dogs Bitten by the European Adder (Vipera Berus), Do Corticosteroids and Supportive Treatment Improve Clinical Outcome Compared to Supportive Treatment Alone?

2018 ◽  
Vol 3 (3) ◽  
Author(s):  
Hannah Harjen
Keyword(s):  
Adverse Reaction ◽  
Open Access ◽  
Clinical Outcome ◽  
Controlled Trials ◽  
Supportive Treatment ◽  
Bottom Line ◽  
Vipera Berus ◽  
Strength Of Evidence ◽  
Prophylactic Administration ◽  
Improve Clinical Outcome

<p><strong>PICO question</strong></p><p>In dogs bitten by the European adder (<em>Vipera berus</em>), do corticosteroids and supportive treatment improve clinical outcome compared to supportive treatment alone?</p><p><strong>Clinical bottom line</strong></p><ul><li>There is currently insufficient strength of evidence to either support or reject the use of glucocorticoids in dogs bitten by the European adder (<em>Vipera berus</em>) and further controlled trials are needed to fully answer this question.</li><li>Glucocorticoids may be indicated in cases of adverse reaction to antivenom treatment although there is not enough evidence to conclude whether there is a benefit to prophylactic administration prior to antivenom treatment.</li></ul><br /> <img src="https://www.veterinaryevidence.org/rcvskmod/icons/oa-icon.jpg" alt="Open Access" /> <img src="https://www.veterinaryevidence.org/rcvskmod/icons/pr-icon.jpg" alt="Peer Reviewed" />

scholarly journals Psychological Effects of Whole-body Electromyostimulation Training: a Controlled Pilot Study in Healthy Volunteers

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Christian Keicher ◽  
Lena Pyrkosch ◽  
Bernd Wolfarth ◽  
Andreas Ströhle
Keyword(s):  
Pilot Study ◽  
Mood State ◽  
Psychological Impact ◽  
Training Session ◽  
Well Being ◽  
Current Level ◽  
Psychological Effects ◽  
Whole Body ◽  
Subjective Well Being ◽  
Visual Analog Scales

Abstract Background Whole-body electromyostimulation (WB-EMS) training is used in popular and health sports to improve muscular performance. Little is known about the possible psychological effects of WB-EMS training. The aim of the study is therefore to investigate the possible psychological effects of WB-EMS training on subjective well-being, relaxation, mood, and perceived stress. Materials and Methods Twenty-five healthy subjects underwent conventional WB-EMS training and Sham training (without the application of electrical stimulation) as part of a randomized, controlled pilot study in a crossover design. Subjective well-being and subjective relaxation were assessed using visual analog scales, the current state of mood was assessed with Multidimensional Mood State Questionnaires (MDBF), and the current level of stress was assessed with Recovery–Stress Questionnaires/Erholungs-Belastungs-Fragebögen (RESTQEBF) before and after training. Results WB-EMS training has a statistically significant positive effect on subjective well-being and subjective relaxation, as well as on the awake subscale of the MDBF. No significant main effect of sequence and no interaction effects were found. Also, compared to a Sham training session, a single WB-EMS training session had no significant effect on mood, nervousness, or the current level of stress. Conclusion Besides physiological effects, WB-EMS might also have a strong psychological impact. WB-EMS could be beneficial for people who, due to their limitations, have problems training on a regular basis and with adequate training intensity. Trial Registration German Clinical Trials Register, DRKS00012583, 22 June 2017.

Prenatal and early postnatal fatty acid status and neurodevelopmental outcome

2007 ◽  
Vol 35 (s1) ◽  
pp. S28-S34 ◽  
Author(s):  
Mijna Hadders-Algra ◽  
Hylco Bouwstra ◽  
Saskia A. van Goor ◽  
D.A. Janneke Dijck-Brouwer ◽  
Frits A.J. Muskiet
Keyword(s):  
Beneficial Effect ◽  
Neurodevelopmental Outcome ◽  
Controlled Trials ◽  
Term Infants ◽  
Gestational Period ◽  
Randomized Controlled ◽  
Nutritional Components ◽  
Acid Status ◽  
Positive Effect ◽  
Long Chain

AbstractThe present review addresses the effect of pre- and postnatal supplementation of nutrition with long-chain polyunsaturated fatty acids (LCPUFA) on neurodevelopmental outcome. The few studies which addressed the effect of prenatal LCPUFA status or prenatal LCPUFA supplementation suggest that a better prenatal arachidonic acid (AA) and doxosahexaenoic acid (DHA) status might be related to a better neurodevelopmental outcome until at least 18 months of age. A review of the few randomized controlled trials on formula supplementation with LCPUFA in preterm infants did not provide evidence for a significant beneficial effect of LCPUFA on developmental outcome. A review of the trials on formula supplementation with LCPUFA in term infants revealed that supplementation with LCPUFA, in particularly supplementation with ≥0.30% DHA, has a beneficial effect on neurodevelopmental outcome until 4 months. The studies could not demonstrate a consistent positive effect beyond that age. It was concluded that the relatively subtle effects of LCPUFA supplementation on neurodevelopmental outcome do not only depend on dosage but also on the gestational period during which the nutritional components are supplied: supplementation prior to term seems to have more effect than that after term.

scholarly journals Can Cytosine Arabinoside With Prednisolone Treatment for Canine Meningoencephalitis of Unknown Origin Increase Survival Time Compared to Prednisolone Treatment Alone?

2018 ◽  
Vol 3 (3) ◽  
Author(s):  
Christopher Stefan Francis Kozlowski Hoey ◽  
Christina Maunder
Keyword(s):  
Open Access ◽  
Combination Therapy ◽  
Survival Time ◽  
Median Survival ◽  
Cytosine Arabinoside ◽  
Median Survival Time ◽  
Unknown Origin ◽  
Bottom Line ◽  
Prednisolone Treatment ◽  
Increase Survival Time

<strong>PICO question</strong><br /><p>In treatment of canine patients with meningoencephalitis of unknown origin (MUO), is combination therapy of cytosine arabinoside (CA) with prednisolone more effective than prednisolone as a sole therapy at increasing survival time?</p><strong>Clinical bottom line</strong><br /><p>Based on current available evidence, cytosine arabinoside with prednisolone has greater median survival time than prednisolone as a sole therapy in dogs with meningoencephalitis of unknown origin. The evidence to support this is very weak, as there are currently a low number of published papers with a relatively small number of cases reported in these studies evaluating cytosine arabinoside with prednisolone or prednisolone as a sole therapy for treatment of meningoencephalitis of unknown origin.</p><p> </p><img src="https://www.veterinaryevidence.org/rcvskmod/icons/oa-icon.jpg" alt="Open Access" /> <img src="https://www.veterinaryevidence.org/rcvskmod/icons/pr-icon.jpg" alt="Peer Reviewed" />

scholarly journals Drug resistance of M. tuberculosis (historical aspects, current level of knowledge)

2020 ◽  
Vol 98 (1) ◽  
pp. 54-61
Author(s):  
I. A. Burmistrova ◽  
A. G. Samoylova ◽  
T. E. Tyulkova ◽  
E. V. Vaniev ◽  
G. S. Balasanyants ◽  
...  
Keyword(s):  
Drug Resistance ◽  
20Th Century ◽  
Current Level ◽  
Drug Resistant ◽  
Historical Aspects ◽  
Level Of Knowledge ◽  
New Research

The review presents data on the frequency of detection of drug resistant (DR) tuberculosis mycobacteria (MTB) as well as on the change in DR patterns in Russia and abroad from the mid-50s of the 20th century till the present. Along with the well-known mechanisms for DR MTB development, it tells about new research describing mutations associated with drug resistance.

scholarly journals Is Topical or Systemic Antimicrobial Therapy More Effective for the Treatment of Feline Acne With Secondary Bacterial Infection?

2018 ◽  
Vol 3 (3) ◽  
Author(s):  
Wendy Kwok ◽  
Kate Charlotte Mellor
Keyword(s):  
Open Access ◽  
Bacterial Infection ◽  
Antimicrobial Therapy ◽  
Systemic Treatment ◽  
Clinical Signs ◽  
Sufficient Evidence ◽  
Bottom Line ◽  
Secondary Bacterial Infection

<strong>PICO question</strong><br /><p>In cats with feline acne and secondary bacterial folliculitis or furunculosis, is topical or systemic antimicrobial therapy superior for reducing time to resolution and severity of clinical signs?</p><strong>Clinical bottom line</strong><br /><p>There is no sufficient evidence to compare topical versus systemic treatment in feline acne with secondary folliculitis/furunculosis.</p><br /> <img src="https://www.veterinaryevidence.org/rcvskmod/icons/oa-icon.jpg" alt="Open Access" /> <img src="https://www.veterinaryevidence.org/rcvskmod/icons/pr-icon.jpg" alt="Peer Reviewed" />

scholarly journals Thrombolytic Therapy in the Acute Period of Aortic Thromboembolism in Cats

2019 ◽  
Vol 4 (2) ◽  
Author(s):  
Joshua Billy Hannabuss
Keyword(s):  
Clinical Trials ◽  
Side Effects ◽  
Open Access ◽  
Thrombolytic Therapy ◽  
Acute Phase ◽  
Large Scale ◽  
Supportive Therapy ◽  
Controlled Clinical Trials ◽  
Bottom Line ◽  
Adverse Side Effects

<strong>PICO question</strong><br /><p>Of cats that present with aortic thromboembolism, do patients that receive thrombolytic therapy in the acute phase have improved survival as compared to those who do not?</p><strong>Clinical bottom line</strong><br /><p>Based on the current available evidence, the use of thrombolytic therapy in the acute phase of aortic thromboembolism (ATE) does not appear to improve survival when compared to conventional supportive therapy. Frequently reported adverse side effects further questions its merits, and large scale controlled clinical trials would be required to further evaluate any benefit in the use of this therapy.</p><br /> <img src="https://www.veterinaryevidence.org/rcvskmod/icons/oa-icon.jpg" alt="Open Access" /> <img src="https://www.veterinaryevidence.org/rcvskmod/icons/pr-icon.jpg" alt="Peer Reviewed" />

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