scholarly journals The Structure of the Trabecular Meshwork, Its Connections to the Ciliary Muscle, and the Effect of Pilocarpine on Outflow Facility in Mice

2014 ◽  
Vol 55 (6) ◽  
pp. 3727 ◽  
Author(s):  
Darryl R. Overby ◽  
Jacques Bertrand ◽  
Martin Schicht ◽  
Friedrich Paulsen ◽  
W. Daniel Stamer ◽  
...  
Keyword(s):  
Trabecular Meshwork ◽  
Ciliary Muscle ◽  
Outflow Facility

scholarly journals Dynamic changes of scleral spur length in different accommodation stimuli states

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Liugui Chen ◽  
Wei Jin ◽  
Xinlei Hao ◽  
Xuejie Li ◽  
Yiqiao Xing
Keyword(s):  
Optical Coherence Tomography ◽  
Receiver Operating Characteristic ◽  
Trabecular Meshwork ◽  
Operating Characteristic ◽  
Roc Curves ◽  
Ciliary Muscle ◽  
Dynamic Changes ◽  
Swept Source ◽  
Variable Distance ◽  
Spur Length

AbstractThis study aimed to evaluate the scleral spur length (SSL) in response to different accommodation stimuli states, as well as the correlation with Schlemm’s canal (SC) and trabecular meshwork (TM). 74 children were recruited for this study. The 0D, − 4D, and − 8.0 D accommodation stimuli state was achieved by looking at a variable distance optotype. The ciliary muscle (CM), scleral spur (SS), SC, and TM were imaged by swept-source optical coherence tomography. The SSL (Method III) increased significantly from 221.56 ± 30.74 μm at base state to 234.99 ± 30.11 μm at − 4D accommodation stimuli state (p = 0.028) and increased to 250.09 ± 29.87 μm at − 8D accommodation stimuli state (p = 0.011). Method III had the largest areas under receiver operating characteristic (ROC) curves (0.798, 95% CI 0.721–0.875). Moreover, CM 1, SC, and trabecular meshwork length (TML) were significantly correlated with SSL (Method III) (p < 0.05). These findings suggest that the contractile ability and compliance of the SS play an important role in maintaining the morphology of the SC. Moreover, the force of accommodation regulates the SC size by increasing the length of SS.

scholarly journals Effects of selective EP2 receptor agonist, omidenepag, on trabecular meshwork cells, Schlemm’s canal endothelial cells and ciliary muscle contraction

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Natsuko Nakamura ◽  
Megumi Honjo ◽  
Reiko Yamagishi ◽  
Nozomi Igarashi ◽  
Rei Sakata ◽  
...  
Keyword(s):  
Trabecular Meshwork ◽  
Receptor Agonist ◽  
Ciliary Muscle ◽  
Cell Permeability ◽  
Schlemm’S Canal ◽  
Schlemm's Canal ◽  
Ep2 Receptor ◽  
Mlc Phosphorylation ◽  
Related Proteins ◽  
Outflow Pathway

AbstractThis study investigated the effects of omidenepag (OMD), a novel selective EP2 receptor agonist, on human trabecular meshwork (HTM) cells, monkey Schlemm’s canal endothelial (SCE) cells, and porcine ciliary muscle (CM) to clarify the mechanism of intraocular pressure (IOP) reduction involving conventional outflow pathway. In HTM and SCE cells, the effects of OMD on transforming growth factor-β2 (TGF-β2)-induced changes were examined. The expression of actin cytoskeleton and extracellular matrix (ECM) proteins, myosin light chain (MLC) phosphorylation in HTM cells were evaluated using real-time quantitative PCR, immunocytochemistry, and western blotting. The expression of barrier-related proteins, ZO-1 and β-catenin, and permeability of SCE cells were evaluated using immunocytochemistry and transendothelial electrical resistance. The CM contraction was determined by contractibility assay. OMD significantly inhibited expression of TGF-β2 induced mRNA, protein, and MLC-phosphorylation on cytoskeletal and ECM remodeling in the HTM dose dependently. In SCE cells, OMD suppressed TGF-β2-induced expression of the barrier-related proteins and decreased SCE monolayer permeability. OMD at 3 µM significantly inhibited CM contraction, however, the effect was not significant at lower concentrations. IOP lowering effect of OMD through conventional outflow pathway is exerted by increasing outflow facilities with the modulation of TM cell fibrosis and SCE cell permeability.

Pharmacological and Functional Characterization of Endothelin Receptors in Bovine Trabecular Meshwork and Ciliary Muscle

2005 ◽  
Vol 37 (4) ◽  
pp. 179-187 ◽  
Author(s):  
Lars Choritz ◽  
Rita Rosenthal ◽  
Michael Fromm ◽  
Michael H. Foerster ◽  
Hagen Thieme
Keyword(s):  
Trabecular Meshwork ◽  
Functional Characterization ◽  
Ciliary Muscle ◽  
Endothelin Receptors

scholarly journals Prostaglandins Increase Trabecular Meshwork Outflow Facility in Cultured Human Anterior Segments

2008 ◽  
Vol 145 (1) ◽  
pp. 114-119 ◽  
Author(s):  
Cindy K. Bahler ◽  
Kyle G. Howell ◽  
Cheryl R. Hann ◽  
Michael P. Fautsch ◽  
Douglas H. Johnson
Keyword(s):  
Trabecular Meshwork ◽  
Outflow Facility ◽  
Anterior Segments

scholarly journals Perturbation of Hyaluronan Synthesis in the Trabecular Meshwork and the Effects on Outflow Facility

2012 ◽  
Vol 53 (8) ◽  
pp. 4616 ◽  
Author(s):  
Kate E. Keller ◽  
Ying Ying Sun ◽  
Yong-Feng Yang ◽  
John M. Bradley ◽  
Ted S. Acott
Keyword(s):  
Trabecular Meshwork ◽  
Outflow Facility

scholarly journals The Relationship Between Age and the Morphology of the Crystalline Lens, Ciliary Muscle, Trabecular Meshwork, and Schlemm’s Canal: An in vivo Swept-Source Optical Coherence Tomography Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Zhangliang Li ◽  
Ziqi Meng ◽  
Wenyong Qu ◽  
Xiuyuan Li ◽  
Pingjun Chang ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Trabecular Meshwork ◽  
Crystalline Lens ◽  
Ciliary Muscle ◽  
Optical Coherence ◽  
Cross Sectional ◽  
Swept Source ◽  
Schlemm's Canal ◽  
The Relationship ◽  
Healthy Participants

Purpose: To evaluate the effects of age on the morphologies of the crystalline lens, ciliary muscle (CM), Schlemm’s canal (SC), and trabecular meshwork (TM) using swept-source optical coherence tomography (SS-OCT).Methods: Images of the crystalline lens and iridocorneal angle were obtained in healthy participants’ eyes using SS-OCT. Morphological parameters of the crystalline lens, CM, and TM/SC were measured, and the relationship between these parameters and age was evaluated.Results: A total of 62 healthy participants were enrolled, with an age range of 7–79 years. With adjustments for the effects of axial length and sex, both the nasal and temporal SC cross-sectional areas (CSA) and the cross-sectional area of the CM (CMA), distance from the scleral spur to the inner apex of the ciliary muscle (IA-SS), and nasal SC volume were negatively correlated with age (P ≤ 0.041). Meanwhile, the lens thickness (LT) (P &lt; 0.001) and lens vault (LV) (P &lt; 0.001) were positively correlated with age, and the radius of the curvature of the anterior lens (ALR) was negatively correlated with age (P &lt; 0.001).Conclusion: Increasing age was associated with a thicker crystalline lens, a steeper anterior lens curvature, an anteriorly located and smaller CM, and a narrower SC.Clinical Trial Registration:https://register.clinicaltrials.gov/prs/app/action/Select Protocol?sid=S000A3JZ&amp;selectaction=Edit&amp;uid=U00019K7&amp;ts=4&amp;cx=-c5xxp8, identifier [NCT04576884].

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