Aqueous Humor Dynamics and Trabecular Meshwork and Anterior Ciliary Muscle Morphologic Changes with Age in Rhesus Monkeys

2003 ◽  
Vol 44 (5) ◽  
pp. 2118 ◽  
Author(s):  
B’Ann True Gabelt ◽  
Johannes Gottanka ◽  
Elke Lu¨tjen-Drecoll ◽  
Paul L. Kaufman
Keyword(s):  
Aqueous Humor ◽  
Trabecular Meshwork ◽  
Rhesus Monkeys ◽  
Ciliary Muscle ◽  
Aqueous Humor Dynamics ◽  
Morphologic Changes

Aqueous humor dynamics in inbred rhesus monkeys with naturally occurring ocular hypertension

2010 ◽  
Vol 91 (6) ◽  
pp. 860-865 ◽  
Author(s):  
Carol B. Toris ◽  
Justin M. Risma ◽  
Janis Gonzales-Martinez ◽  
Marsha A. McLaughlin ◽  
William W. Dawson
Keyword(s):  
Ocular Hypertension ◽  
Aqueous Humor ◽  
Rhesus Monkeys ◽  
Aqueous Humor Dynamics ◽  
Naturally Occurring

scholarly journals Pharmacologic Trabeculectomy—Modulation of Aqueous Humor Outflow Through the Trabecular Meshwork

2015 ◽  
Vol 8 (1) ◽  
pp. 46
Author(s):  
Syed Shoeb Ahmad ◽  
Syed Zia-ur-Rahman ◽  
Norlina Ramli ◽  
Shuaibah Abdul Ghani ◽  
◽  
...  
Keyword(s):  
Aqueous Humor ◽  
Trabecular Meshwork ◽  
Ciliary Body ◽  
Aqueous Humor Outflow ◽  
Aqueous Humor Dynamics ◽  
Aqueous Outflow

“Pharmacologic trabeculectomy” is a term used to describe the modulation of aqueous outflow by the biochemical manipulation of the trabecular meshwork. Most of the medications currently in use either reduce aqueous production or increase its outflow through the ciliary body. However, there is a new group of agents being investigated, which can increase the facility of aqueous humor outflow through the trabecular meshwork. Thus, these agents will be able to provide a more physiologic means to control aqueous humor dynamics. This review sheds light on this concept of “medical trabeculectomy.”

scholarly journals Multiscale mathematical modeling of aqueous humor dynamics: Applications for precision care in glaucoma

2019 ◽  
Vol 2 (1) ◽  
Author(s):  
Matthew Lang ◽  
Alon Harris ◽  
Alice Chandra Verticchio Vercellin ◽  
Sunu Mathew ◽  
Giovanna Guidoboni
Keyword(s):  
Risk Factors ◽  
Aqueous Humor ◽  
Trabecular Meshwork ◽  
Venous Pressure ◽  
Anterior Chamber Angle ◽  
Model Simulations ◽  
Unknown Variable ◽  
Aqueous Humor Dynamics ◽  
Potential Impact ◽  
The Impact

Background and Hypothesis: Reduction of intraocular pressure (IOP) resulting from overproduction or impaired outflow of aqueous humor is, to date, the only approved medical treatment for the disease. IOP is determined by the balance between aqueous humor production at the ciliary body and drainage at the anterior chamber angle. A mathematical model describing aqueous humor (AH) flow was employed in order to study the effects of glaucoma medications and risk factors on IOP. Experimental Design or Project Methods: IOP can be calculated as the unknown variable in the mathematical balance between AH inflow (Jin) and outflow (Jout). Model simulations using MATLAB were used to calculate IOP in conditions of varied trabecular meshwork resistance (R) over changes in episcleral venous pressure (EVP), uveosclearal outflow facility (Cuv), and ciliary capillary blood pressure (cBP) in order to simulate the effects of EVP reducing medications, prostaglandin analogs, and systemic BP, respectively. Results: The simulated effects of EVP reducing medications and prostaglandin analogs led to IOP decrease of 13.12%, 5.51%, and 2.88% for conditions of R0, 3R0, and 6R0, respectively, where R0 is equal to the trabecular meshwork resistance when IOP = EVP. The simulated effects of prostaglandin analogs resulted an IOP decrease of 13.73%, 18.34%, and 19.83%, for conditions of R0, 3R0, and 6R0, respectively. The simulated effects of increasing systemic BP resulted in an IOP increase of 49.88%, 58.51%, and 60.71% for conditions of R0, 3R0, and 6R0, respectively. Conclusion and Potential Impact: The model simulations predict differential efficacy in IOP reducing medications in patients of varied R as well as the differential impact of systemic BP on IOP in patients of varied R. This model has the potential to predict the IOP reducing effect of medications in an individual as well as the impact of risk factors such as systemic BP on IOP.

Effect of dexamethasone on the expression of MMPs, adenosine A1 receptors and NFKB by human trabecular meshwork cells

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Normie Aida Mohd Nasir ◽  
Renu Agarwal ◽  
Anna Krasilnikova ◽  
Siti Hamimah Sheikh Abdul Kadir ◽  
Igor Iezhitsa
Keyword(s):  
Extracellular Matrix ◽  
Western Blot ◽  
Trabecular Meshwork ◽  
Culture Media ◽  
Smooth Muscle Actin ◽  
Adenosine A1 Receptors ◽  
Trabecular Meshwork Cells ◽  
Aqueous Humor Dynamics ◽  
Nfkb Activation ◽  
Adenosine A1

AbstractObjectivesSteroid-induced ocular hypertension and glaucoma are associated with extracellular matrix remodeling at the trabecular meshwork (TM) of the eye due to reduced secretion of matrix metalloproteinases (MMPs), a family of enzymes regulating extracellular matrix proteolysis. Several biological functions of steroids are known to involve regulation of adenosine A1 receptors (A1AR) and nuclear factor kappa B (NFKB). Since MMPs expression in TM has been shown to be regulated by A1AR as well as transcription factors, it is likely that dexamethasone-induced changes in aqueous humor dynamics involve reduced MMP and A1AR expression and reduced NFKB activation. Hence, the current study investigated the association of dexamethasone-induced reduction in MMP secretion with reduced NFKB activation and A1AR expression.MethodsHuman trabecular meshwork cells (HTMCs) were characterized by estimating myocilin and alpha smooth muscle actin expression and then were treated with dexamethasone 100 nM for 2, 5 and 7 days. The MMP secretion was estimated in culture media using Western blot. Immunocytochemistry (ICC) and ELISA were done to investigate the effect of dexamethasone on NFKB phosphorylation. A1AR expression in HTMCs was determined using Western blot and ELISA.ResultsDexamethasone caused a significant reduction in both MMP-2 and -9 expression compared to untreated group after five and seven days but not after two days of culture. Significantly reduced phosphorylated NFKB and A1AR protein levels were detected in dexamethasone treated compared to vehicle treated HTMCs after five days of culture.ConclusionsDexamethasone reduces MMP-2 and -9 secretion by HTMCs and this effect of dexamethasone is associated with reduced NFKB phosphorylation and A1AR expression.

Effects of Cyclocryotherapy on Aqueous Humor Dynamics in Cats

1988 ◽  
Vol 106 (3) ◽  
pp. 396-403 ◽  
Author(s):  
E. J. Higginbotham ◽  
D. A. Lee ◽  
S. P. Bartels ◽  
T. Richardson ◽  
M. Miller
Keyword(s):  
Aqueous Humor ◽  
Aqueous Humor Dynamics

Primary Trabecular Meshwork Cells Incubated in Human Aqueous Humor Differ from Cells Incubated in Serum Supplements

2005 ◽  
Vol 46 (8) ◽  
pp. 2848 ◽  
Author(s):  
Michael P. Fautsch ◽  
Kyle G. Howell ◽  
Anne M. Vrabel ◽  
M. Cristine Charlesworth ◽  
David C. Muddiman ◽  
...  
Keyword(s):  
Aqueous Humor ◽  
Trabecular Meshwork ◽  
Trabecular Meshwork Cells
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