STUDIES ON THE IN VITRO ANTITUMOR ACTIVITY OF FATTY ACIDS: III. SATURATED MONOCARBOXYLIC ACIDS

1961 ◽  
Vol 39 (4) ◽  
pp. 713-719 ◽  
Author(s):  
Susan Tolnai ◽  
Joseph F. Morgan
Keyword(s):  
Fatty Acids ◽  
Antitumor Activity ◽  
Royal Jelly ◽  
Decanoic Acid ◽  
Carbon Chain ◽  
Ehrlich Carcinoma ◽  
Carbon Chain Length ◽  
Monocarboxylic Acids ◽  
Ph Conditions

Previous studies on the in vitro antitumor activity of 10-hydroxy-2-decenoic acid from royal jelly and of saturated dibasic fatty acids have been extended to a series of saturated monocarboxylic acids ranging from C3to C18. A widespread ability to inhibit the development of the ascites forms of the 6C3HED lymphosarcoma, Ehrlich carcinoma, and TA3mammary carcinoma has been found under acid pH conditions. In general, the antitumor activity of the saturated monocarboxylic acids was most pronounced in compounds with a carbon chain length of C8to C14. One member of this series, capric (decanoic) acid, was found to possess marked antitumor activity at physiological pH.

STUDIES ON THE IN VITRO ANTITUMOR ACTIVITY OF FATTY ACIDS: V. UNSATURATED ACIDS

1962 ◽  
Vol 40 (7) ◽  
pp. 869-875 ◽  
Author(s):  
Susan Tolnai ◽  
Joseph F. Morgan
Keyword(s):  
Fatty Acids ◽  
Antitumor Activity ◽  
Unsaturated Fatty Acids ◽  
Relative Effectiveness ◽  
Carbon Chain ◽  
Ehrlich Carcinoma ◽  
Carbon Chain Length ◽  
Ascites Tumors ◽  
Arachidonic Acids

Previous studies on the in vitro antitumor activity of saturated mono- and dicarboxylic fatty acids have been extended to a series of unsaturated fatty acids ranging in carbon chain length from C6to C20- All 10 compounds tested exhibited some activity at pH 4.0 against the ascites forms of the Ehrlich carcinoma, 6C3HED lymphosarcoma, and TA3mammary carcinoma. Only three compounds (2-decenoic, linoleic, and linolenic acids) were found to be active at neutrality against all three tumors, while four compounds (2-nonenoic, 10-undecenoic, oleic, and arachidonic acids) were active against one or two tumors under neutral conditions. Considerable variations were encountered in the relative effectiveness of these compounds against the three ascites tumors. The compounds with the most marked in vitro antitumor activity were linoleic and linolenic acids.

STUDIES ON THE IN VITRO ANTITUMOR ACTIVITY OF FATTY ACIDS: V. UNSATURATED ACIDS

1962 ◽  
Vol 40 (1) ◽  
pp. 869-875 ◽  
Author(s):  
Susan Tolnai ◽  
Joseph F. Morgan
Keyword(s):  
Fatty Acids ◽  
Antitumor Activity ◽  
Unsaturated Fatty Acids ◽  
Relative Effectiveness ◽  
Carbon Chain ◽  
Ehrlich Carcinoma ◽  
Carbon Chain Length ◽  
Ascites Tumors ◽  
Arachidonic Acids

Previous studies on the in vitro antitumor activity of saturated mono- and dicarboxylic fatty acids have been extended to a series of unsaturated fatty acids ranging in carbon chain length from C6to C20- All 10 compounds tested exhibited some activity at pH 4.0 against the ascites forms of the Ehrlich carcinoma, 6C3HED lymphosarcoma, and TA3mammary carcinoma. Only three compounds (2-decenoic, linoleic, and linolenic acids) were found to be active at neutrality against all three tumors, while four compounds (2-nonenoic, 10-undecenoic, oleic, and arachidonic acids) were active against one or two tumors under neutral conditions. Considerable variations were encountered in the relative effectiveness of these compounds against the three ascites tumors. The compounds with the most marked in vitro antitumor activity were linoleic and linolenic acids.

STUDIES ON THE IN VITRO ANTITUMOR ACTIVITY OF FATTY ACIDS: II. SATURATED DICARBOXYLIC ACIDS

1960 ◽  
Vol 38 (6) ◽  
pp. 597-603 ◽  
Author(s):  
Joseph F. Morgan ◽  
Susan Tolnai ◽  
Gordon F. Townsend
Keyword(s):  
Fatty Acids ◽  
Antitumor Activity ◽  
Royal Jelly ◽  
Dicarboxylic Acids ◽  
Ehrlich Carcinoma ◽  
Decenoic Acid ◽  
Fatty Acid Chain ◽  
Transplantable Leukemia ◽  
Akr Mice

Previous studies, which showed that 10-hydroxy-2-decenoic acid from royal jelly possessed in vitro antitumor activity, have been extended to saturated dicarboxylic fatty acids. Seven of eight compounds tested in a series of chain length from C3 to C10 completely prevented the development of the ascites forms of the 6C3HED lymphosarcoma, the Ehrlich carcinoma, and the TA3 mammary carcinoma, as well as the transplantable leukemia of AKR mice. This in vitro antitumor activity could be demonstrated only at pH values below 5.0 and required admixture of the tumor cells and test compounds prior to inoculation of the mice. In general, the antitumor activity of the saturated dicarboxylic acids was found to increase progressively with increasing length of the fatty acid chain.

STUDIES ON THE IN VITRO ANTITUMOR ACTIVITY OF FATTY ACIDS: II. SATURATED DICARBOXYLIC ACIDS

1960 ◽  
Vol 38 (1) ◽  
pp. 597-603 ◽  
Author(s):  
Joseph F. Morgan ◽  
Susan Tolnai ◽  
Gordon F. Townsend
Keyword(s):  
Fatty Acids ◽  
Antitumor Activity ◽  
Royal Jelly ◽  
Dicarboxylic Acids ◽  
Ehrlich Carcinoma ◽  
Decenoic Acid ◽  
Fatty Acid Chain ◽  
Transplantable Leukemia ◽  
Akr Mice

Previous studies, which showed that 10-hydroxy-2-decenoic acid from royal jelly possessed in vitro antitumor activity, have been extended to saturated dicarboxylic fatty acids. Seven of eight compounds tested in a series of chain length from C3 to C10 completely prevented the development of the ascites forms of the 6C3HED lymphosarcoma, the Ehrlich carcinoma, and the TA3 mammary carcinoma, as well as the transplantable leukemia of AKR mice. This in vitro antitumor activity could be demonstrated only at pH values below 5.0 and required admixture of the tumor cells and test compounds prior to inoculation of the mice. In general, the antitumor activity of the saturated dicarboxylic acids was found to increase progressively with increasing length of the fatty acid chain.

The Representation of Lower Molecular Weight Fatty Acids by the Bligh and Dyer Extraction Method

1972 ◽  
Vol 29 (12) ◽  
pp. 1786-1787 ◽  
Author(s):  
R. E. Hurst
Keyword(s):  
Fatty Acids ◽  
Molecular Weight ◽  
Organic Phase ◽  
Lipid Extraction ◽  
Decanoic Acid ◽  
Carbon Chain ◽  
Carbon Chain Length ◽  
Low Molecular Weight ◽  
Distilled Water ◽  
Chloroform Methanol

The Bligh and Dyer method of lipid extraction was investigated to determine the distribution of low molecular weight free fatty acids in the organic phase. Two solvent systems were studied: one using chloroform, methanol, and distilled water; the other using an aqueous fish extract containing natural buffer in place of distilled water. The low molecular weight fatty acids were not well represented in the chloroform layer and the presence of a buffer further depressed their distribution into the organic phase. Proportionately with increased molecular weight a greater percent of acid was recovered in the chloroform. Essentially total partitioning into the organic phase in both systems occurred at a carbon chain length of ten (decanoic acid).

STUDIES ON THE IN VITRO ANTITUMOR ACTIVITY OF FATTY ACIDS: VI. DERIVATIVES OF MONO- AND DI-CARBOXYLIC AND UNSATURATED FATTY ACIDS

1962 ◽  
Vol 40 (10) ◽  
pp. 1367-1373 ◽  
Author(s):  
Susan Tolnai ◽  
Joseph F. Morgan
Keyword(s):  
Fatty Acids ◽  
Antitumor Activity ◽  
Mammary Carcinoma ◽  
Unsaturated Fatty Acids ◽  
Methyl Esters ◽  
Ehrlich Carcinoma ◽  
Neutral Ph ◽  
Derivatives Of

Previous studies on the in vitro antitumor activity of saturated and unsaturated fatty acids have been extended to a series of hydroxy and keto derivatives and methyl esters of fatty acids. All compounds were tested against the ascites forms of the Ehrlich carcinoma, the Gardner lymphosarcoma, and the TA3 mammary carcinoma. Marked differences between the antitumor activity of the parent compounds and those of the substituted derivatives were observed. Most consistent in vitro antitumor activity was shown at both acid and neutral pH levels by the keto-derivatives of unsaturated fatty acids.

STUDIES ON THE IN VITRO ANTITUMOR ACTIVITY OF FATTY ACIDS: IV. THE ESTERS OF ACIDS CLOSELY RELATED TO 10-HYDROXY- 2-DECENOIC ACID FROM ROYAL JELLY AGAINST TRANSPLANTABLE MOUSE LEUKEMIA

1961 ◽  
Vol 39 (11) ◽  
pp. 1765-1770 ◽  
Author(s):  
Gordon F. Townsend ◽  
William H. Brown ◽  
Ethel E. Felauer ◽  
Barbara Hazlett
Keyword(s):  
Fatty Acids ◽  
Royal Jelly ◽  
Dicarboxylic Acids ◽  
Leukemic Cells ◽  
Straight Chain ◽  
Decenoic Acid ◽  
Monocarboxylic Acids ◽  
Mouse Leukemia ◽  
Related Compounds

Previous studies have shown that whole royal jelly, a fraction from royal jelly (10-hydroxy-2-decenoic acid), and certain closely related dicarboxylic acids, some of which are also found in royal jelly, will inhibit the development of transplantable AKR leukemia when the pH is below 5.6.The ester of 10-hydroxy-2-decenoic acid from royal jelly was found to be just as effective against AKR leukemic cells as the acid itself, with the added advantage that it could be used at neutrality.Through the testing of a series of mono- and di-carboxylic acids, as well as other closely related compounds, the activity has been shown to be associated mainly with 9- and 10-carbon straight chain monocarboxylic acids either saturated or unsaturated. Slight variations in the structure either reduce or destroy the activity.

STUDIES ON THE IN VITRO ANTITUMOR ACTIVITY OF FATTY ACIDS: VI. DERIVATIVES OF MONO- AND DI-CARBOXYLIC AND UNSATURATED FATTY ACIDS

1962 ◽  
Vol 40 (1) ◽  
pp. 1367-1373
Author(s):  
Susan Tolnai ◽  
Joseph F. Morgan
Keyword(s):  
Fatty Acids ◽  
Antitumor Activity ◽  
Mammary Carcinoma ◽  
Unsaturated Fatty Acids ◽  
Methyl Esters ◽  
Ehrlich Carcinoma ◽  
Neutral Ph ◽  
Derivatives Of

Previous studies on the in vitro antitumor activity of saturated and unsaturated fatty acids have been extended to a series of hydroxy and keto derivatives and methyl esters of fatty acids. All compounds were tested against the ascites forms of the Ehrlich carcinoma, the Gardner lymphosarcoma, and the TA3 mammary carcinoma. Marked differences between the antitumor activity of the parent compounds and those of the substituted derivatives were observed. Most consistent in vitro antitumor activity was shown at both acid and neutral pH levels by the keto-derivatives of unsaturated fatty acids.

scholarly journals Liquid-Liquid Equilibrium Behavior and In Vitro Digestion Simulation of Medium Chain Fatty Acids

2020 ◽  
Author(s):  
Ericsem Pereira ◽  
Antonio J. A. Meirelles ◽  
Guilherme J. Maximo
Keyword(s):  
Fatty Acids ◽  
Chain Length ◽  
Pancreatic Enzyme ◽  
In Vitro Digestion ◽  
Carbon Chain ◽  
Carbon Chain Length ◽  
Medium Chain ◽  
Medium Chain Fatty Acids ◽  
Chain Fatty Acids

The absorption of medium-chain fatty acids (MCFA) depends on the solubility of these components in the gastric fluid. Parameters such as the total MCFA concentration, carboxyl ionization level, and carbon chain length affect the solubility of these molecules. Moreover, the enzymatic lipolysis of solubilized triacylglycerol (TAG) molecules may depend on the carbon chain length of the fatty acids (FAs) components and their positions on the glycerol backbone. This present study aimed at investigating the effect of electrolyte usually formed during the gastric digestion phase on the solubility of MCFA, and evaluating the influence of the FA carbon chain length on the lipolysis rate during the in vitro digestion simulation. The results obtained here showed that the increasing of electrolyte concentrations tend to decrease the mutual solubility of systems composed by the caproic and caprylic fatty acids + sodium chloride, sodium bicarbonate, and potassium chloride solutions. We also observed that a conventional version of the thermodynamic UNIQUAC model was able to correlate the liquid-liquid phase behavior of the electrolyte solutions. Regarding the in vitro digestion simulation, the experimental data indicated that the action of the pancreatic enzyme occurred preferentially in TAG molecules comprised of short and medium-chain fatty acids.

ANTITUMOR EFFECT OF COLLOIDAL SILVER BISILICATE IN EXPERIMENTAL IN VITRO AND IN VIVO STUDIES

2019 ◽  
Vol 65 (5) ◽  
pp. 760-765
Author(s):  
Margarita Tyndyk ◽  
Irina Popovich ◽  
A. Malek ◽  
R. Samsonov ◽  
N. Germanov ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Tumor Growth ◽  
Tumor Cells ◽  
Human Tumor ◽  
Significant Inhibition ◽  
In Vivo Studies ◽  
Ehrlich Carcinoma ◽  
In Vivo Experiments

The paper presents the results of the research on the antitumor activity of a new drug - atomic clusters of silver (ACS), the colloidal solution of nanostructured silver bisilicate Ag6Si2O7 with particles size of 1-2 nm in deionized water. In vitro studies to evaluate the effect of various ACS concentrations in human tumor cells cultures (breast cancer, colon carcinoma and prostate cancer) were conducted. The highest antitumor activity of ACS was observed in dilutions from 2.7 mg/l to 5.1 mg/l, resulting in the death of tumor cells in all studied cell cultures. In vivo experiments on transplanted Ehrlich carcinoma model in mice consuming 0.75 mg/kg ACS with drinking water revealed significant inhibition of tumor growth since the 14th day of experiment (maximally by 52% on the 28th day, p < 0.05) in comparison with control. Subcutaneous injections of 2.5 mg/kg ACS inhibited Ehrlich's tumor growth on the 7th and 10th days of the experiment (p < 0.05) as compared to control.

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