STUDIES ON THE IN VITRO ANTITUMOR ACTIVITY OF FATTY ACIDS: V. UNSATURATED ACIDS

1962 ◽  
Vol 40 (1) ◽  
pp. 869-875 ◽  
Author(s):  
Susan Tolnai ◽  
Joseph F. Morgan
Keyword(s):  
Fatty Acids ◽  
Antitumor Activity ◽  
Unsaturated Fatty Acids ◽  
Relative Effectiveness ◽  
Carbon Chain ◽  
Ehrlich Carcinoma ◽  
Carbon Chain Length ◽  
Ascites Tumors ◽  
Arachidonic Acids

Previous studies on the in vitro antitumor activity of saturated mono- and dicarboxylic fatty acids have been extended to a series of unsaturated fatty acids ranging in carbon chain length from C6to C20- All 10 compounds tested exhibited some activity at pH 4.0 against the ascites forms of the Ehrlich carcinoma, 6C3HED lymphosarcoma, and TA3mammary carcinoma. Only three compounds (2-decenoic, linoleic, and linolenic acids) were found to be active at neutrality against all three tumors, while four compounds (2-nonenoic, 10-undecenoic, oleic, and arachidonic acids) were active against one or two tumors under neutral conditions. Considerable variations were encountered in the relative effectiveness of these compounds against the three ascites tumors. The compounds with the most marked in vitro antitumor activity were linoleic and linolenic acids.

STUDIES ON THE IN VITRO ANTITUMOR ACTIVITY OF FATTY ACIDS: V. UNSATURATED ACIDS

1962 ◽  
Vol 40 (7) ◽  
pp. 869-875 ◽  
Author(s):  
Susan Tolnai ◽  
Joseph F. Morgan
Keyword(s):  
Fatty Acids ◽  
Antitumor Activity ◽  
Unsaturated Fatty Acids ◽  
Relative Effectiveness ◽  
Carbon Chain ◽  
Ehrlich Carcinoma ◽  
Carbon Chain Length ◽  
Ascites Tumors ◽  
Arachidonic Acids

Previous studies on the in vitro antitumor activity of saturated mono- and dicarboxylic fatty acids have been extended to a series of unsaturated fatty acids ranging in carbon chain length from C6to C20- All 10 compounds tested exhibited some activity at pH 4.0 against the ascites forms of the Ehrlich carcinoma, 6C3HED lymphosarcoma, and TA3mammary carcinoma. Only three compounds (2-decenoic, linoleic, and linolenic acids) were found to be active at neutrality against all three tumors, while four compounds (2-nonenoic, 10-undecenoic, oleic, and arachidonic acids) were active against one or two tumors under neutral conditions. Considerable variations were encountered in the relative effectiveness of these compounds against the three ascites tumors. The compounds with the most marked in vitro antitumor activity were linoleic and linolenic acids.

STUDIES ON THE IN VITRO ANTITUMOR ACTIVITY OF FATTY ACIDS: III. SATURATED MONOCARBOXYLIC ACIDS

1961 ◽  
Vol 39 (4) ◽  
pp. 713-719 ◽  
Author(s):  
Susan Tolnai ◽  
Joseph F. Morgan
Keyword(s):  
Fatty Acids ◽  
Antitumor Activity ◽  
Royal Jelly ◽  
Decanoic Acid ◽  
Carbon Chain ◽  
Ehrlich Carcinoma ◽  
Carbon Chain Length ◽  
Monocarboxylic Acids ◽  
Ph Conditions

Previous studies on the in vitro antitumor activity of 10-hydroxy-2-decenoic acid from royal jelly and of saturated dibasic fatty acids have been extended to a series of saturated monocarboxylic acids ranging from C3to C18. A widespread ability to inhibit the development of the ascites forms of the 6C3HED lymphosarcoma, Ehrlich carcinoma, and TA3mammary carcinoma has been found under acid pH conditions. In general, the antitumor activity of the saturated monocarboxylic acids was most pronounced in compounds with a carbon chain length of C8to C14. One member of this series, capric (decanoic) acid, was found to possess marked antitumor activity at physiological pH.

STUDIES ON THE IN VITRO ANTITUMOR ACTIVITY OF FATTY ACIDS: VI. DERIVATIVES OF MONO- AND DI-CARBOXYLIC AND UNSATURATED FATTY ACIDS

1962 ◽  
Vol 40 (10) ◽  
pp. 1367-1373 ◽  
Author(s):  
Susan Tolnai ◽  
Joseph F. Morgan
Keyword(s):  
Fatty Acids ◽  
Antitumor Activity ◽  
Mammary Carcinoma ◽  
Unsaturated Fatty Acids ◽  
Methyl Esters ◽  
Ehrlich Carcinoma ◽  
Neutral Ph ◽  
Derivatives Of

Previous studies on the in vitro antitumor activity of saturated and unsaturated fatty acids have been extended to a series of hydroxy and keto derivatives and methyl esters of fatty acids. All compounds were tested against the ascites forms of the Ehrlich carcinoma, the Gardner lymphosarcoma, and the TA3 mammary carcinoma. Marked differences between the antitumor activity of the parent compounds and those of the substituted derivatives were observed. Most consistent in vitro antitumor activity was shown at both acid and neutral pH levels by the keto-derivatives of unsaturated fatty acids.

STUDIES ON THE IN VITRO ANTITUMOR ACTIVITY OF FATTY ACIDS: VI. DERIVATIVES OF MONO- AND DI-CARBOXYLIC AND UNSATURATED FATTY ACIDS

1962 ◽  
Vol 40 (1) ◽  
pp. 1367-1373
Author(s):  
Susan Tolnai ◽  
Joseph F. Morgan
Keyword(s):  
Fatty Acids ◽  
Antitumor Activity ◽  
Mammary Carcinoma ◽  
Unsaturated Fatty Acids ◽  
Methyl Esters ◽  
Ehrlich Carcinoma ◽  
Neutral Ph ◽  
Derivatives Of

Previous studies on the in vitro antitumor activity of saturated and unsaturated fatty acids have been extended to a series of hydroxy and keto derivatives and methyl esters of fatty acids. All compounds were tested against the ascites forms of the Ehrlich carcinoma, the Gardner lymphosarcoma, and the TA3 mammary carcinoma. Marked differences between the antitumor activity of the parent compounds and those of the substituted derivatives were observed. Most consistent in vitro antitumor activity was shown at both acid and neutral pH levels by the keto-derivatives of unsaturated fatty acids.

STUDIES ON THE IN VITRO ANTITUMOR ACTIVITY OF FATTY ACIDS: II. SATURATED DICARBOXYLIC ACIDS

1960 ◽  
Vol 38 (6) ◽  
pp. 597-603 ◽  
Author(s):  
Joseph F. Morgan ◽  
Susan Tolnai ◽  
Gordon F. Townsend
Keyword(s):  
Fatty Acids ◽  
Antitumor Activity ◽  
Royal Jelly ◽  
Dicarboxylic Acids ◽  
Ehrlich Carcinoma ◽  
Decenoic Acid ◽  
Fatty Acid Chain ◽  
Transplantable Leukemia ◽  
Akr Mice

Previous studies, which showed that 10-hydroxy-2-decenoic acid from royal jelly possessed in vitro antitumor activity, have been extended to saturated dicarboxylic fatty acids. Seven of eight compounds tested in a series of chain length from C3 to C10 completely prevented the development of the ascites forms of the 6C3HED lymphosarcoma, the Ehrlich carcinoma, and the TA3 mammary carcinoma, as well as the transplantable leukemia of AKR mice. This in vitro antitumor activity could be demonstrated only at pH values below 5.0 and required admixture of the tumor cells and test compounds prior to inoculation of the mice. In general, the antitumor activity of the saturated dicarboxylic acids was found to increase progressively with increasing length of the fatty acid chain.

Glucose-stimulated acrolein production from unsaturated fatty acids

2004 ◽  
Vol 23 (2) ◽  
pp. 101-105 ◽  
Author(s):  
R Medina-Navarro ◽  
G Duran-Reyes ◽  
M Diaz-Flores ◽  
J J Hicks ◽  
J Kumate R
Keyword(s):  
Lipid Peroxidation ◽  
Fatty Acids ◽  
Unsaturated Fatty Acids ◽  
Tissue Injury ◽  
Acid Product ◽  
Hydroperoxide Formation ◽  
Fatty Acid Product ◽  
Arachidonic Acids

Glucose auto-oxidation may be a significant source of reactive oxygen species (ROS), and also be important in the lipid peroxidation process, accompanied by the release of toxic reactive products. We wanted to demonstrate that acrolein can be formed directly and actively from free fatty acids in a hyperglycemic environment. A suspension of linoleic and arachidonic acids (2.5 mM) was exposed to different glucose concentrations (5, 10 and 15 mmol/L) in vitro. The samples were extracted with organic solvents, partitioned, followed at 255 / 267 nm, and analysed using capillary electrophoresis and mass spectroscopy. The total release of aldehydes significantly (P ≤ 0.01) increased from 1.0 to 5.1, 8.3 and 13.1 μmol/L after 6 hours of incubation, proportional to glucose concentrations. It was possible to verify a correlate hydroperoxide formation as well. Among the lipid peroxidation products, acrolein (5% of total) and its condensing product, 4-hydroxy-hexenal, were identified. From the results presented here, it was possible to demonstrate the production of acrolein, probably as a fatty acid product, due to free radicals generated from the glucose auto-oxidation process. The results led us to propose that acrolein, which is one of the most toxic aldehydes, is produced during hyperglycemic states, and may lead to tissue injury, as one of the initial problems to be linked to high levels of glucose in vivo.

STUDIES ON THE IN VITRO ANTITUMOR ACTIVITY OF FATTY ACIDS: II. SATURATED DICARBOXYLIC ACIDS

1960 ◽  
Vol 38 (1) ◽  
pp. 597-603 ◽  
Author(s):  
Joseph F. Morgan ◽  
Susan Tolnai ◽  
Gordon F. Townsend
Keyword(s):  
Fatty Acids ◽  
Antitumor Activity ◽  
Royal Jelly ◽  
Dicarboxylic Acids ◽  
Ehrlich Carcinoma ◽  
Decenoic Acid ◽  
Fatty Acid Chain ◽  
Transplantable Leukemia ◽  
Akr Mice

Previous studies, which showed that 10-hydroxy-2-decenoic acid from royal jelly possessed in vitro antitumor activity, have been extended to saturated dicarboxylic fatty acids. Seven of eight compounds tested in a series of chain length from C3 to C10 completely prevented the development of the ascites forms of the 6C3HED lymphosarcoma, the Ehrlich carcinoma, and the TA3 mammary carcinoma, as well as the transplantable leukemia of AKR mice. This in vitro antitumor activity could be demonstrated only at pH values below 5.0 and required admixture of the tumor cells and test compounds prior to inoculation of the mice. In general, the antitumor activity of the saturated dicarboxylic acids was found to increase progressively with increasing length of the fatty acid chain.

TISSUE CULTURE AND THE STUDY OF ANTICANCER AGENTS

1966 ◽  
Vol 44 (2) ◽  
pp. 339-343 ◽  
Author(s):  
Susan Tolnai
Keyword(s):  
Fatty Acids ◽  
Tumor Cells ◽  
Anticancer Agents ◽  
Antitumor Agents ◽  
Unsaturated Fatty Acids ◽  
Ascites Tumor ◽  
Mouse Tumors ◽  
Arachidonic Acids

In a quest for potential antitumor agents, more than 100 fatty acids and their derivatives were tested against transplantable mouse tumors with both in vivo and in vitro methods. Three compounds, 2,3-decenoic acid, linoleic acid, and linolenic acid, were found to arrest the growth of three types of ascites tumor cells, while 2-nonenoic, 10-undecenoic, oleic, and arachidonic acids were effective to a varying degree. The cytotoxic effects of these unsaturated fatty acids on monolayer cultures of Ehrlich ascites tumor cells and of normal mouse embryos were evaluated in experiments in which graded concentrations of the test materials incorporated in the culture medium were used.

scholarly journals Liquid-Liquid Equilibrium Behavior and In Vitro Digestion Simulation of Medium Chain Fatty Acids

2020 ◽  
Author(s):  
Ericsem Pereira ◽  
Antonio J. A. Meirelles ◽  
Guilherme J. Maximo
Keyword(s):  
Fatty Acids ◽  
Chain Length ◽  
Pancreatic Enzyme ◽  
In Vitro Digestion ◽  
Carbon Chain ◽  
Carbon Chain Length ◽  
Medium Chain ◽  
Medium Chain Fatty Acids ◽  
Chain Fatty Acids

The absorption of medium-chain fatty acids (MCFA) depends on the solubility of these components in the gastric fluid. Parameters such as the total MCFA concentration, carboxyl ionization level, and carbon chain length affect the solubility of these molecules. Moreover, the enzymatic lipolysis of solubilized triacylglycerol (TAG) molecules may depend on the carbon chain length of the fatty acids (FAs) components and their positions on the glycerol backbone. This present study aimed at investigating the effect of electrolyte usually formed during the gastric digestion phase on the solubility of MCFA, and evaluating the influence of the FA carbon chain length on the lipolysis rate during the in vitro digestion simulation. The results obtained here showed that the increasing of electrolyte concentrations tend to decrease the mutual solubility of systems composed by the caproic and caprylic fatty acids + sodium chloride, sodium bicarbonate, and potassium chloride solutions. We also observed that a conventional version of the thermodynamic UNIQUAC model was able to correlate the liquid-liquid phase behavior of the electrolyte solutions. Regarding the in vitro digestion simulation, the experimental data indicated that the action of the pancreatic enzyme occurred preferentially in TAG molecules comprised of short and medium-chain fatty acids.

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