THE EFFECT OF GONADAL HORMONES ON LIVER NUCLEIC ACIDS IN THE IMMATURE PULLET

1949 ◽  
Vol 27d (4) ◽  
pp. 200-206 ◽  
Author(s):  
D. G. Chapman ◽  
A. A. Hanson ◽  
R. H. Common ◽  
W. A. Maw
Keyword(s):  
Nucleic Acids ◽  
Ribonucleic Acid ◽  
Testosterone Propionate ◽  
Gonadal Hormones ◽  
Gonadal Hormone ◽  
Desoxyribonucleic Acid

The ribonucleic acid, desoxyribonucleic acid, and the ratio of ribonucleic acid to desoxyribonucleic acid in the liver of immature pullets treated with 4.5 mgm. testosterone propionate over a 12-day period were all increased when this treatment was supplemented by treatment with estrogen. The possible significance of these effects in relation to other effects of similar gonadal hormone treatments is discussed.

scholarly journals THE BEHAVIOR OF THE NUCLEIC ACIDS DURING THE EARLY DEVELOPMENT OF THE SEA URCHIN EGG (ARBACIA)

1948 ◽  
Vol 31 (5) ◽  
pp. 457-457
Author(s):  
Gerhard Schmidt ◽  
Liselotte Hecht ◽  
S. J. Thannhauser
Keyword(s):  
Nucleic Acids ◽  
Early Development ◽  
Sea Urchin ◽  
Ribonucleic Acid ◽  
P Fractions ◽  
Desoxyribonucleic Acid ◽  
Sea Urchin Egg

The authors wish to correct an error in the paper "The behavior of the nucleic acids during the early development of the sea urchin egg (Arbacia)" (J. Gen. Physiol., 1947–48, 31, 203). Owing to an oversight, the figures for the amounts of various P fractions in a single Arbacia egg have been erroneously expressed in γ x 10–3 units (Tables I and II, page 205; the last two lines of page 206). The figures should have been expressed in γ x 10–5 units. Thus, the fertilized Arbacia egg contains an average of 20 γ x 10–5 ribonucleic acid P and 0.7 to 1 γ x 10–5 desoxyribonucleic acid P.

scholarly journals The Metabolism of Chromosomal Ribonucleic Acid in Drosophila Salivary Glands and its Relation to Synthesis of Desoxyribonucleic Acid

1959 ◽  
Vol 5 (3) ◽  
pp. 461-467 ◽  
Author(s):  
Rachel McMaster-Kaye ◽  
J. Herbert Taylor
Keyword(s):  
Nucleic Acids ◽  
Salivary Glands ◽  
Ribonucleic Acid ◽  
Time Course ◽  
Marked Decrease ◽  
Morphological Differentiation ◽  
Nuclear Size ◽  
Large Decrease ◽  
Desoxyribonucleic Acid ◽  
Autoradiographic Technique

Incorporation of adenine-8-C14 into chromosomal nucleic acids of Drosophila salivary glands has been observed with the autoradiographic technique. RNA-C14 and DNA-C14 were detected as the fractions extractable by ribonuclease digestion and resistant to ribonuclease, respectively. Extractions with desoxyribonuclease and acids were also used to identify the nucleic acids. Time-course curves were determined from grain counts. RNA-C14 concentration reached a maximum in 2 hours, and decreased after the 4th hour. DNA-C14 concentration reached its maximum within 8 hours, and showed no decreases during a 48-hour experiment. In the latter part of the period of observation, morphological differentiation of the gland occurred, the decrease in RNA-C14 became very rapid, and a large increase in DNA-C14 was observed. Marked decrease in RNA-C14 and increase in DNA-C14 were detectable in a few hours when isotope was administered shortly before visible differentiation of the gland. Measurements of nuclear size indicated no significant decreases in RNA-C14 amount prior to the period of differentiation. During this later period, a large decrease in RNA-C14 amount occurs suddenly, and the same amount of C14 is added simultaneously to the DNA fraction, as expected if RNA-C14 is utilized in the synthesis of DNA.

THE INFLUENCE OF GONADAL HORMONES ON THE SERUM VITAMIN A OF THE IMMATURE PULLET

1949 ◽  
Vol 27d (2) ◽  
pp. 37-42 ◽  
Author(s):  
D. G. Chapman ◽  
M. Gluck ◽  
R. H. Common ◽  
W. A. Maw
Keyword(s):  
Vitamin A ◽  
Domestic Fowl ◽  
Intramuscular Injection ◽  
Testosterone Propionate ◽  
Serum Vitamin ◽  
Gonadal Hormones ◽  
Gonadal Hormone ◽  
Hormone Activity ◽  
Estradiol Dipropionate

The serum vitamin A level of sexually immature pullets was increased threefold to fourfold by intramuscular injection of 24 mgm. estradiol dipropionate plus 4.5 mgm. testosterone propionate administered in six equal doses over a 12-day period as compared with the level in similar pullets receiving only testosterone propionate. It is suggested that gonadal hormone activity is one of the factors that regulate serum vitamin A levels in the domestic fowl.

scholarly journals THE BEHAVIOR OF THE NUCLEIC ACIDS DURING THE EARLY DEVELOPMENT OF THE SEA URCHIN EGG (ARBACIA)

1948 ◽  
Vol 31 (3) ◽  
pp. 203-207 ◽  
Author(s):  
Gerhard Schmidt ◽  
Liselotte Hecht ◽  
S. J. Thannhauser
Keyword(s):  
Nucleic Acids ◽  
Early Development ◽  
Sea Urchin ◽  
Ribonucleic Acid ◽  
Desoxyribonucleic Acid ◽  
Sea Urchin Egg

1. The unfertilized Arbacia egg contains an average of 20γ x 10–3 ribonucleic acid and 0.7 to 1γ x 10–3 desoxyribonucleic acid. 2. During the first 24 hours of development, the amount of ribonucleic acid per embryo remains practically unchanged whereas that of desoxyribonucleic acid steadily increases. At the end of this period, the amount of desoxyribonucleic acid per embryo is 10 to 15 times larger than that of the unfertilized egg.

Gonadal hormones organize and modulate the circadian system of the rat

1981 ◽  
Vol 241 (1) ◽  
pp. R62-R66 ◽  
Author(s):  
H. E. Albers
Keyword(s):  
Testosterone Propionate ◽  
Wheel Running ◽  
Activity Rhythm ◽  
Gonadal Hormones ◽  
Circadian System ◽  
Female Rats ◽  
Constant Darkness ◽  
Before And After ◽  
Free Running ◽  
Free Running Period

The circadian wheel-running rhythms of gonadectomized adult male, female, and perinatally androgenized female rats, maintained in constant darkness, were examined before and after implantation of Silastic capsules containing cholesterol (C) or estradiol-17 beta (E). The free-running period of the activity rhythm (tau) before capsule implantation tended to be shorter in animals exposed to perinatal androgen. Administration of C did not reliably alter tau in any group. E significantly shortened tau in 100% of females injected with oil on day 3 of life. In females, injected with 3.5 micrograms testosterone propionate on day 3, and males, E shortened or lengthened tau, with the direction and magnitude of this change in tau inversely related to the length of the individual's pretreatment tau. These data indicate that the presence of perinatal androgen does not eliminate the sensitivity of the circadian system of the rat to estrogen, since estrogen alters tau in a manner that depends on its pretreatment length.

METABOLISM OF LEPTOSPIRES: II. THE ACTION OF 8-AZAGUANINE

1967 ◽  
Vol 13 (12) ◽  
pp. 1621-1629 ◽  
Author(s):  
Russell C. Johnson ◽  
Palmer Rogers
Keyword(s):  
Nucleic Acids ◽  
Ribonucleic Acid ◽  
Rna Synthesis ◽  
Inhibitory Effect ◽  
Relative Increase ◽  
Purine Biosynthesis ◽  
Low Concentrations

Both the pathogen Leptospira pomona and the saprophyte L. biflexa Patoc I can convert exogenous adenine, guanine, and 8-azaguanine to the corresponding nucleotide and incorporate them into nucleic acids. L. pomona is inhibited by low concentrations of 8-azaguanine (50 μg/ml) and this inhibition is associated with less than a 5% replacement of the ribonucleic acid (RNA) guanine residues by the analogue. Guanine possessed the highest activity for antagonizing the inhibitory effect of 8-azaguanine. The biosynthetic process of L. pomona most affected by the analogue was a relative increase in RNA synthesis. The analogue-resistant L. biflexa incorporated 1/10 as much 8-azaguanine as L. pomona. The higher rate of purine biosynthesis, in addition to the lesser amount of 8-azaguanine incorporated, may account for the analogue resistance of L. biflexa.

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