Preparation of Some Thio Derivatives of Pyridinecarbothioamides

1993 ◽  
Vol 58 (5) ◽  
pp. 1195-1197 ◽  
Author(s):  
Věra Klimešová
Keyword(s):  
Pyridine Derivatives ◽  
Derivatives Of

Within the framework of antituberculous research of pyridine derivatives we were also interested in the preparation of alkylthioderivatives, that were further transformed into corresponding pyridinecarbothioamides.

Synthesis of azaanthraquinones: homolytic substitution of pyridines

1982 ◽  
Vol 35 (7) ◽  
pp. 1451 ◽  
Author(s):  
DW Cameron ◽  
KR Deutscher ◽  
GI Feutrill ◽  
DE Hunt
Keyword(s):  
Ring Closure ◽  
Pyridine Derivatives ◽  
Derivatives Of ◽  
Substituted 1 ◽  
Homolytic Substitution

Synthesis of specific di- and tri-hydroxyazaanthraquinones by Friedel-Crafts procedures is limited by orientational ambiguity and by the lack of reactivity of pyridine derivatives in electrophilic acylation processes; however, suitable pyridines have been made to undergo radical benzoylation and benzylation at unsubstituted positions 2, 4 and 6. In particular, derivatives of pyridine-3-carbo-nitrile have been benzoylated at positions 2 and 4. Ring closure by intramolecular Houben-Hoesch reaction has then led to specifically substituted 1-and 2-azaanthraquinones and thence to the antibiotic bostrycoidin (1).

New 4-Hydroxypyridine and 4-Hydroxyquinoline Derivatives as Inhibitors of NADH-ubiquinone Reductase in the Respiratory Chain

1989 ◽  
Vol 44 (7-8) ◽  
pp. 609-616 ◽  
Author(s):  
Kun Hoe Chung ◽  
Kwang Yun Cho ◽  
Yasuko Asami ◽  
Nobutaka Takahashi ◽  
Shigeo Yoshida
Keyword(s):  
Electron Transport ◽  
Respiratory Chain ◽  
Side Chain ◽  
Pyridine Derivatives ◽  
Transport Function ◽  
Optimal Length ◽  
Structure Activity ◽  
Membrane Effect ◽  
Relationship Of ◽  
Derivatives Of

Many derivatives of 2,3-dim ethoxy-4-hydroxypyridine, which were designed from examination of the structure-activity relationship of piericidins, were tested for inhibition of NADH-UQ reductase. The lipophilic side chain of those compounds was indicated to be a key part for activity and its optimal length was conjectured. By the use of two different phases of assay material, intact mitochondria and submitochondria, the size of a membrane effect was shown to depend on the structure of the side chain. 4-Hydroxyquinoline derivatives were also tested for an analogous role in relation to the electron transport function of menaquinone, and they were proven to be inhibitors of NADH-UQ reductase as good as the pyridine derivatives.

THE ADDITION OF CYANOACETAMIDE TO α-METHOXYBENZALACETOPHENONE

1934 ◽  
Vol 11 (3) ◽  
pp. 395-405 ◽  
Author(s):  
C. F. H. Allen ◽  
J. A. Scarrow
Keyword(s):  
Addition Product ◽  
Methoxyl Group ◽  
Pyridine Derivatives ◽  
Reaction Products ◽  
Alkaline Catalyst ◽  
Partial Degradation ◽  
Derivatives Of

When attempts were made to add substances of the type HA to α-methoxybenzalacetophenone in the presence of an alkaline catalyst, it was found that the components were largely recovered unchanged, except in the case of cyanoacetamide; the addition product from the latter is a hydropyridine. The hydropyridine gives two distinct series of reaction products; in the first, the substances are all pyridine derivatives and always contain a methoxyl group. In the second, partial degradation has taken place, giving rise to cyclic derivatives of a δ-ketonic acid.

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