Pyrylium and pyridine derivatives of thieno[3,2-b]thiophene ? New heteroaromat1c systems

1979 ◽  
Vol 15 (10) ◽  
pp. 1152-1152
Author(s):  
N. N. Alekseev ◽  
S. V. Tolkunov
Keyword(s):  
Pyridine Derivatives ◽  
Derivatives Of

Synthesis of azaanthraquinones: homolytic substitution of pyridines

1982 ◽  
Vol 35 (7) ◽  
pp. 1451 ◽  
Author(s):  
DW Cameron ◽  
KR Deutscher ◽  
GI Feutrill ◽  
DE Hunt
Keyword(s):  
Ring Closure ◽  
Pyridine Derivatives ◽  
Derivatives Of ◽  
Substituted 1 ◽  
Homolytic Substitution

Synthesis of specific di- and tri-hydroxyazaanthraquinones by Friedel-Crafts procedures is limited by orientational ambiguity and by the lack of reactivity of pyridine derivatives in electrophilic acylation processes; however, suitable pyridines have been made to undergo radical benzoylation and benzylation at unsubstituted positions 2, 4 and 6. In particular, derivatives of pyridine-3-carbo-nitrile have been benzoylated at positions 2 and 4. Ring closure by intramolecular Houben-Hoesch reaction has then led to specifically substituted 1-and 2-azaanthraquinones and thence to the antibiotic bostrycoidin (1).

New 4-Hydroxypyridine and 4-Hydroxyquinoline Derivatives as Inhibitors of NADH-ubiquinone Reductase in the Respiratory Chain

1989 ◽  
Vol 44 (7-8) ◽  
pp. 609-616 ◽  
Author(s):  
Kun Hoe Chung ◽  
Kwang Yun Cho ◽  
Yasuko Asami ◽  
Nobutaka Takahashi ◽  
Shigeo Yoshida
Keyword(s):  
Electron Transport ◽  
Respiratory Chain ◽  
Side Chain ◽  
Pyridine Derivatives ◽  
Transport Function ◽  
Optimal Length ◽  
Structure Activity ◽  
Membrane Effect ◽  
Relationship Of ◽  
Derivatives Of

Many derivatives of 2,3-dim ethoxy-4-hydroxypyridine, which were designed from examination of the structure-activity relationship of piericidins, were tested for inhibition of NADH-UQ reductase. The lipophilic side chain of those compounds was indicated to be a key part for activity and its optimal length was conjectured. By the use of two different phases of assay material, intact mitochondria and submitochondria, the size of a membrane effect was shown to depend on the structure of the side chain. 4-Hydroxyquinoline derivatives were also tested for an analogous role in relation to the electron transport function of menaquinone, and they were proven to be inhibitors of NADH-UQ reductase as good as the pyridine derivatives.

Preparation of Some Thio Derivatives of Pyridinecarbothioamides

1993 ◽  
Vol 58 (5) ◽  
pp. 1195-1197 ◽  
Author(s):  
Věra Klimešová
Keyword(s):  
Pyridine Derivatives ◽  
Derivatives Of

Within the framework of antituberculous research of pyridine derivatives we were also interested in the preparation of alkylthioderivatives, that were further transformed into corresponding pyridinecarbothioamides.

THE ADDITION OF CYANOACETAMIDE TO α-METHOXYBENZALACETOPHENONE

1934 ◽  
Vol 11 (3) ◽  
pp. 395-405 ◽  
Author(s):  
C. F. H. Allen ◽  
J. A. Scarrow
Keyword(s):  
Addition Product ◽  
Methoxyl Group ◽  
Pyridine Derivatives ◽  
Reaction Products ◽  
Alkaline Catalyst ◽  
Partial Degradation ◽  
Derivatives Of

When attempts were made to add substances of the type HA to α-methoxybenzalacetophenone in the presence of an alkaline catalyst, it was found that the components were largely recovered unchanged, except in the case of cyanoacetamide; the addition product from the latter is a hydropyridine. The hydropyridine gives two distinct series of reaction products; in the first, the substances are all pyridine derivatives and always contain a methoxyl group. In the second, partial degradation has taken place, giving rise to cyclic derivatives of a δ-ketonic acid.

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