A Novel 3E Method for Synthesis of 5-nitro 2-diethylamino 6-methyl pyridine Organic Crystal by Nitration of 2-diethylamino 6-methyl pyridine with H2SO4/HNO3

4-nitro 2-diethylamino 5-methyl pyridine (P-NitroC10N2H16) as an organic crystal which is the useful intermediate for pharmaceutical synthesis and for production of organic materials, which was usually synthesized by nitration of 2-diethylamino 5-methyl pyridine with H2SO4/HNO3 mixtures, followed by extraction, chromatography column separation and recrystallization three-step procedures. Here an innovation process for synthesizing 4-nitro 2-diethylamino 5-methyl pyridine crystal from the nitration of C10N2H16 without needing chromatography column separation step is presented. The novel organic synthesis process is more ecologic, economical, and environmentally-friendly (3E) than the traditional organic synthesis process since the chromatography column separation process is a material-consuming and energy-consuming step, which needs to dispose of a large amount of wasted silica beads.

Origin of the Ir-Si Bond Shortening in Ir-NSiN complexes

The Ir-Si bond distances reported for Ir-(fac-k3-NSiNOPy) and Ir-(fac-k3-NSiN4MeOPy) species (NSiNOPy = bis(pyridine-2-yloxy)methylsilyl and NSiN4MeOPy = bis(4-methyl-pyridine-2-yloxy)methylsily) are in the range of 2.220-2.235 Å. These values are in the lowest...