Methyl pyridine derivatives of 14-membered tetraaza macrocycles. A new host with high selectivity for cadmium †

1999 ◽  
pp. 4331-4339 ◽  
Author(s):  
Judite Costa ◽  
Rita Delgado ◽  
Michael G. B. Drew ◽  
Vitor Félix
Keyword(s):  
High Selectivity ◽  
Pyridine Derivatives ◽  
New Host ◽  
Tetraaza Macrocycles ◽  
Derivatives Of ◽  
Methyl Pyridine

Synthesis of azaanthraquinones: homolytic substitution of pyridines

1982 ◽  
Vol 35 (7) ◽  
pp. 1451 ◽  
Author(s):  
DW Cameron ◽  
KR Deutscher ◽  
GI Feutrill ◽  
DE Hunt
Keyword(s):  
Ring Closure ◽  
Pyridine Derivatives ◽  
Derivatives Of ◽  
Substituted 1 ◽  
Homolytic Substitution

Synthesis of specific di- and tri-hydroxyazaanthraquinones by Friedel-Crafts procedures is limited by orientational ambiguity and by the lack of reactivity of pyridine derivatives in electrophilic acylation processes; however, suitable pyridines have been made to undergo radical benzoylation and benzylation at unsubstituted positions 2, 4 and 6. In particular, derivatives of pyridine-3-carbo-nitrile have been benzoylated at positions 2 and 4. Ring closure by intramolecular Houben-Hoesch reaction has then led to specifically substituted 1-and 2-azaanthraquinones and thence to the antibiotic bostrycoidin (1).

New 4-Hydroxypyridine and 4-Hydroxyquinoline Derivatives as Inhibitors of NADH-ubiquinone Reductase in the Respiratory Chain

1989 ◽  
Vol 44 (7-8) ◽  
pp. 609-616 ◽  
Author(s):  
Kun Hoe Chung ◽  
Kwang Yun Cho ◽  
Yasuko Asami ◽  
Nobutaka Takahashi ◽  
Shigeo Yoshida
Keyword(s):  
Electron Transport ◽  
Respiratory Chain ◽  
Side Chain ◽  
Pyridine Derivatives ◽  
Transport Function ◽  
Optimal Length ◽  
Structure Activity ◽  
Membrane Effect ◽  
Relationship Of ◽  
Derivatives Of

Many derivatives of 2,3-dim ethoxy-4-hydroxypyridine, which were designed from examination of the structure-activity relationship of piericidins, were tested for inhibition of NADH-UQ reductase. The lipophilic side chain of those compounds was indicated to be a key part for activity and its optimal length was conjectured. By the use of two different phases of assay material, intact mitochondria and submitochondria, the size of a membrane effect was shown to depend on the structure of the side chain. 4-Hydroxyquinoline derivatives were also tested for an analogous role in relation to the electron transport function of menaquinone, and they were proven to be inhibitors of NADH-UQ reductase as good as the pyridine derivatives.

Pharmacological Evaluation of Some New 6-Amino/Methyl Pyridine Derivatives.

ChemInform ◽  
2003 ◽  
Vol 34 (31) ◽  
Author(s):  
Inguva Ravlee ◽  
Ramaiah Sivakumar ◽  
Nithyanantham Muruganantham ◽  
Navaneetharaman Anbalagan ◽  
Vedachalam Gunasekaran ◽  
...  
Keyword(s):  
Pyridine Derivatives ◽  
Pharmacological Evaluation ◽  
Methyl Pyridine

Synthesis and in vitro anti-proliferative effects of 3-(hetero)aryl substituted 3-[(prop-2-ynyloxy)(thiophen-2-yl)methyl]pyridine derivatives on various cancer cell lines

2014 ◽  
Vol 24 (5) ◽  
pp. 1366-1372 ◽  
Author(s):  
Upendar Reddy Chamakura ◽  
E. Sailaja ◽  
Balakrishna Dulla ◽  
Arunasree M. Kalle ◽  
S. Bhavani ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Cancer Cell Lines ◽  
Pyridine Derivatives ◽  
Methyl Pyridine

Binding of calcium ions to 2,3-dicarboxy derivatives of pectic acid

1986 ◽  
Vol 51 (10) ◽  
pp. 2259-2270 ◽  
Author(s):  
Anna Malovíková ◽  
Rudolf Kohn
Keyword(s):  
Activity Coefficient ◽  
Calcium Ions ◽  
High Selectivity ◽  
Carboxyl Groups ◽  
Free Enthalpy ◽  
Pectic Acid ◽  
Considerable Degradation ◽  
Oxidation Degradation ◽  
Derivatives Of ◽  
Low Activity

Using a two-step oxidation of pectic acid (85% of D-galacturonan in the preparation) a series of 2,3-dicarboxy derivatives (Na+ form) was prepared containing 4.2 to 8.5 mmol of carboxyl groups per gram (COOH g-1). After the centrifugation of the diluted suspensions of the Ca-salts of these polyacids the activity of the calcium counterions (aCa2+) was determined using the metallochromic indicator (tetramethylmurexide) and the activity coefficient γCa2+ was calculated. Using potentiometric titrations of polyacids with potassium and calcium hydroxides the decrease in electrostatic free enthalpy, Δ(Gel/N)KCa, of the cation exchange Ca2+ → 2 K+ was determined. In the course of the oxidation, degradation of the macromolecules took place, characterized by the limit viscosity number [η]. In spite of the considerable degradation, preparations with higher oxidation degrees display a high selectivity in the exchange of cations Ca2+ → 2 K+, similar to that determined recently by us in 2,3-dicarboxy derivatives of starch and amylose. The strong binding of Ca2+ ions to the investigated substances is also documented by very low activity coefficient values, γCa2+, ranging from 0.057 to 0.037.

Methylmercury(II) derivatives of Pyridine-2(1H)-thione

1976 ◽  
Vol 29 (6) ◽  
pp. 1383 ◽  
Author(s):  
AJ Canty ◽  
A Marker
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Nitric Acid ◽  
Magnetic Resonance ◽  
Sodium Bicarbonate ◽  
Nuclear Magnetic Resonance Spectra ◽  
Derivatives Of ◽  
Methyl Pyridine ◽  
Magnetic Resonance Spectra ◽  
Nuclear Magnetic

Methylmercuric nitrate reacts with pyridine-2(lH)-thione (C5H5NS) in acetone to give methyl-(pyridine-2(1H)-thione)mercury(11) nitrate, [MeHg(C5H5NS)] NO3. This complex reacts with sodium bicarbonate in acetone to give methyl(pyridine-2-thiolato)mercury(11), MeHg(C5H4NS).Infrared, Raman, and nuclear magnetic resonance spectra indicate that MeHgH is bonded to sulphur in both complexes, and that protonation of nitrogen occurs on reaction of MeHg(CsH,NS) with nitric acid to give [MeHg(C5H5NS)] NO3.

Sign in / Sign up

Export Citation Format

Share Document