substituted 1
Recently Published Documents


TOTAL DOCUMENTS

2274
(FIVE YEARS 46)

H-INDEX

51
(FIVE YEARS 0)

2021 ◽  
Vol 05 (02) ◽  
pp. 1-9
Author(s):  
Ghadir Khalaf ◽  
Sameerah Mustafa ◽  
Ghaidaa Kadhim ◽  
Hadeel Hasan

Alkaline hydrolysis rates coefficients for the series of methyl 3-(7-substituted-1-naphthyl) propynoate was calculated in 70%v/v dimethylsulphoxide-water at various temperatures (25,30,40, and 50̊ C). The pKa values of 3-(7-substituted-1-naphthyl) propynoic acid and (E)- 3-(7-substituted-1-naphthyl) propenoic acid calculated in 80%w/w 2-methoxyethanol-water at room temperature (25.0̊ C). logk2 of esterification rate coefficients for 3-(7-substituted-1-naphthyl) propynioc acid and (E)-3(7-substituted-1-naphthyl) propenioc acid with DDM have been measured at 30.0̊ C. Reversed substituent dipolar effects were found in the ionization reaction. In the esterification reaction with DDM the result show similar but reduced substituted effects. Rate retardations was found in the alkaline hydrolysis. It could be result from steric effect or reversal of substituent dipolar effect with a combination of steric effect.


2021 ◽  
Vol 17 ◽  
pp. 2765-2772
Author(s):  
Krishna M S Adusumalli ◽  
Lakshmi N S Konidena ◽  
Hima B Gandham ◽  
Krishnaiah Kumari ◽  
Krishna R Valluru ◽  
...  

A simple and efficient protocol for the construction of 1-aminoisoquinolines was achieved by treating 2-(2-oxo-2-phenylethyl)benzonitriles with amines in the presence of Me3Al. The reaction proceeds via a domino nucleophilic addition with subsequent intramolecular cyclisation. This method provides a wide variety of substituted 1-aminoisoquinolines with good functional group tolerance. Furthermore, the synthetic utility of this protocol was demonstrated in the successful synthesis of the antitumor agent CWJ-a-5 in gram scale.


Synthesis ◽  
2021 ◽  
Author(s):  
Bianca Seitz ◽  
Thomas Schneider ◽  
Nikola Majstorovic ◽  
Maximilian Fleischmann ◽  
Gerhard Maas

A variety of 4-CF3-quinolines bearing an aryl (or cyclopropyl, tert-butyl, trimethylsilyl) group at C-2 and a nitro group at ring position 6, 7 or 8 have been prepared in good to high yields from 3-substituted 1-CF3-prop-2-yne 1-iminium triflate salts and o-, m- or p-nitroaniline. These reactions include an aza-Michael reaction at room temperature followed by an intramolecular electrophilic aromatic substitution step, which requires additional thermal activation in most cases. In contrast, the conjugate addition of 2,4-dinitroanilines at the acetylenic iminium ions proceeds much more slowly and some of the adducts can be converted thermally into 2-(2,4-dinitrophenyl)-5-CF3-pyrroles. Analogously, 2-(4-pyridyl)-5-CF3-pyrroles were obtained from 3-aryl-1-CF3-propyne iminium salts and 4-aminopyridinium triflate. A novel variation of the Truce-Smiles rearrangement is probably involved in the formation of these pyrroles.


2021 ◽  
Vol 6 (36) ◽  
pp. 9599-9607
Author(s):  
Fátima C. Teixeira ◽  
Inês F. Antunes ◽  
M. João M. Curto ◽  
M. Teresa Duarte ◽  
Vânia André ◽  
...  

2021 ◽  
Author(s):  
Xi Chen ◽  
Haibing Shao ◽  
Tingting Zhu ◽  
Zhihua Chen ◽  
Yan Hu ◽  
...  

Abstract We developed a new chromogenic and fluorescent "off–on" 1,8-naphthalimide-derivated chemosensor 1 based on an F−-triggered desilylation reaction. It showed significant variations in UV/Visible absorption (510 nm) and fluorescence emission wavelength (570 nm) for selective detection of fluorides in tetrahydrofuran. Moreover, chemodosimeter 1-loaded test strips were successfully fabricated todetect fluorides efficiently.


2021 ◽  
Vol 76 (9) ◽  
pp. 495-501
Author(s):  
Bianca Seitz ◽  
Gerhard Maas

Abstract Bis(trifluoromethyl)-substituted quinolino[8,7-h]quinolines and quinolino[7,8-h]quinolines have been prepared from 3-substituted 1-CF3-prop-2-yne 1-iminium triflate salts and 1,5- and 1,8-diaminonaphthalene, respectively, by a twofold pyridoannelation sequence. These transformations do not require any additional reagent and can be performed at remarkable mild thermal conditions.


Sign in / Sign up

Export Citation Format

Share Document