Simultaneous vibration and high-speed microscopy to study mechanotransduction in living cells

Author(s):  
David W. Holdsworth ◽  
Hristo N. Nikolov ◽  
Jen Au ◽  
Kim Beaucage ◽  
Jessica Kishimoto ◽  
...  
Keyword(s):  
Nanoscale ◽  
2013 ◽  
Vol 5 (18) ◽  
pp. 8355 ◽  
Author(s):  
Jing Li ◽  
Zhifeng Deng ◽  
Daixie Chen ◽  
Zhuo Ao ◽  
Quanmei Sun ◽  
...  
Keyword(s):  

1931 ◽  
Vol 15 (2) ◽  
pp. 147-153 ◽  
Author(s):  
E. Newton Harvey ◽  
Alfred L. Loomis

A new type of camera system is described capable of taking 1200 pictures a second through a microscope objective. Photographs showing the destruction of Arbacia eggs by high frequency sound waves indicate that the disintegration occurs in less than 1/1200 second. Eggs drawn out into spindle or tadpole shapes suggest that rapid movements of the fluid tearing the eggs may be responsible for the disintegration. Although no cavitated air bubbles show in the photographs, other experiments make it likely that the rapid fluid movement is the result of submicroscopic cavitation.


2013 ◽  
Vol 84 (11) ◽  
pp. 113707 ◽  
Author(s):  
Kai Bodensiek ◽  
Weixing Li ◽  
Paula Sánchez ◽  
Schanila Nawaz ◽  
Iwan A. T. Schaap

2015 ◽  
Vol 104 (9) ◽  
pp. 2845-2854 ◽  
Author(s):  
Yuma Yamada ◽  
Sandra Milena Vergara Perez ◽  
Mai Tabata ◽  
Jiro Abe ◽  
Yukari Yasuzaki ◽  
...  

2011 ◽  
Vol 366 (1580) ◽  
pp. 2979-2986 ◽  
Author(s):  
Ingo Wohlgemuth ◽  
Corinna Pohl ◽  
Joerg Mittelstaet ◽  
Andrey L. Konevega ◽  
Marina V. Rodnina

Speed and accuracy of protein synthesis are fundamental parameters for the fitness of living cells, the quality control of translation, and the evolution of ribosomes. The ribosome developed complex mechanisms that allow for a uniform recognition and selection of any cognate aminoacyl-tRNA (aa-tRNA) and discrimination against any near-cognate aa-tRNA, regardless of the nature or position of the mismatch. This review describes the principles of the selection—kinetic partitioning and induced fit—and discusses the relationship between speed and accuracy of decoding, with a focus on bacterial translation. The translational machinery apparently has evolved towards high speed of translation at the cost of fidelity.


1926 ◽  
Vol 23 (3) ◽  
pp. 284-287 ◽  
Author(s):  
J. A. Crowther

The absorption by matter of energy from a beam of X-rays follows laws which are now well known. The first stage is the ejection from the absorbing atom of a high speed electron. This electron, in turn, produces pairs of ions from some of the molecules through which it passes until its energy is all spent. The process is essentially a discontinuous one in space, and the proportion of atoms affected at a given time is always exceedingly minute, even with an intense beam of radiation. With a beam of average intensity an individual atom would suffer ionisation, on an average, about once in a million years.


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