scholarly journals Attentional control in Parkinson's disease is dependent on COMT val158met genotype

Brain ◽  
2008 ◽  
Vol 131 (2) ◽  
pp. 397-408 ◽  
Author(s):  
C. H. Williams-Gray ◽  
A. Hampshire ◽  
R. A. Barker ◽  
A. M. Owen
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Attentional Control ◽  
Comt Val158met

scholarly journals Top–Down Attentional Control in Parkinson's Disease: Salient Considerations

2010 ◽  
Vol 22 (5) ◽  
pp. 848-859 ◽  
Author(s):  
Roshan Cools ◽  
Robert Rogers ◽  
Roger A. Barker ◽  
Trevor W. Robbins
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Attentional Control ◽  
Direct Evidence ◽  
Control Mechanisms ◽  
Set Shifting ◽  
Top Down ◽  
Bottom Up ◽  
Salient Dimension ◽  
Dimensional Salience

Cognitive dysfunction in Parkinson's disease (PD) has been hypothesized to reflect a failure of cortical control. In keeping with this hypothesis, some of the cognitive deficits in PD resemble those seen in patients with lesions in the lateral pFC, which has been associated with top–down attentional control. However, there is no direct evidence for a failure of top–down control mechanisms in PD. Here we fill this gap by demonstrating disproportionate control by bottom–up attention to dimensional salience during attentional set shifting. Patients needed significantly more trials to criterion than did controls when shifting to a low-salient dimension while, remarkably, needing significantly fewer trials to criterion than did controls when shifting to a high-salient dimension. Thus, attention was captured by bottom–up attention to salient information to a greater extent in patients than in controls. The results provide a striking reinterpretation of prior set-shifting data and provide the first direct evidence for a failure of top–down attentional control, resembling that seen after catecholamine depletion in the pFC.

Planning ability in Parkinson's disease is influenced by the COMT val158met polymorphism

2004 ◽  
Vol 19 (8) ◽  
pp. 885-891 ◽  
Author(s):  
Thomas Foltynie ◽  
Terry E. Goldberg ◽  
Simon G.J. Lewis ◽  
Andrew D. Blackwell ◽  
Bhaskar S. Kolachana ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Comt Val158met ◽  
Val158met Polymorphism ◽  
Planning Ability

The COMT Val158Met polymorphism affects the response to entacapone in Parkinson's disease: A randomized crossover clinical trial

2011 ◽  
Vol 69 (1) ◽  
pp. 111-118 ◽  
Author(s):  
Jean-Christophe Corvol ◽  
Cécilia Bonnet ◽  
Fanny Charbonnier-Beaupel ◽  
Anne-Marie Bonnet ◽  
Marie-Hélène Fiévet ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Clinical Trial ◽  
Parkinson's Disease ◽  
Comt Val158met ◽  
Val158met Polymorphism

Visual misperceptions and hallucinations in Parkinson's disease: Dysfunction of attentional control networks?

2011 ◽  
Vol 26 (12) ◽  
pp. 2154-2159 ◽  
Author(s):  
James M. Shine ◽  
Glenda M. Halliday ◽  
Sharon L. Naismith ◽  
Simon J.G. Lewis
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Attentional Control ◽  
Control Networks

scholarly journals Dopaminergic denervation severity depends on COMT Val158Met polymorphism in Parkinson's disease

2015 ◽  
Vol 21 (5) ◽  
pp. 471-476 ◽  
Author(s):  
Julia Muellner ◽  
Iman Gharrad ◽  
Marie-Odile Habert ◽  
Aurélie Kas ◽  
Jean-Baptiste Martini ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Comt Val158met ◽  
Val158met Polymorphism

ERRATA

2002 ◽  
Vol 8 (4) ◽  
pp. 604-605
Author(s):  
M. LÉVESQUE ◽  
S. LEMAY ◽  
S. CHOUINARD ◽  
P. BLANCHET ◽  
M.-A. BÉDARD ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
African American ◽  
Executive Function ◽  
Attentional Control ◽  
Neuropsychological Tests ◽  
Reading Level ◽  
Cambridge University ◽  
Friday Morning ◽  
Age Range

First erratum: The following is a correction for an error that occurred in the Journal of the International Neuropsychological Society, Vol. 8, No. 2. An abstract titled “Parkinson's Disease Affects the Attentional Control of Unpracticed Movements,” by M. Lévesque, S. Lemay, S. Chouinard, P. Blanchet, M.-A. Bédard, and F. Richer, was accidently left out. This abstract was supposed to appear on p. 230 after C. Boulet et al., in the Executive Function subsection of Poster 4, which was a part of the Friday Morning, February 16, group of sessions.Second erratum: The following is a correction for an error that occurred in Journal of the International Neuropsychological Society, 8:2. On page 276, the abstract at the bottom of the left column has a laterality error, and “right” was supposed to appear instead of “left.”Third erratum: The following is a correction for an error that occurred in the Journal of the International Neuropsychological Society, Vol. 8, No. 3. The error occurred in the article titled “Reading level attenuates differences in neuropsychological tests performance between African American and White Elders,” pp. 341–348, by Manly et al. On page 343, under the subheading “Reading Level,” the last line in the paragraph should state the age range as 65–74 and not 70–75 years.Cambridge University Press and the authors regret the inconvenience that these inadvertent errors may have caused.

Association of COMT Val158Met polymorphism with wearing-off susceptibility in Parkinson’s disease

2014 ◽  
Vol 36 (4) ◽  
pp. 621-623 ◽  
Author(s):  
Jianxing Liu ◽  
Pan Chen ◽  
Meihua Guo ◽  
Lechun Lu ◽  
Lihua Li
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Comt Val158met ◽  
Val158met Polymorphism ◽  
Wearing Off

scholarly journals The role of dysfunctional attentional control networks in visual misperceptions in Parkinson's disease

2013 ◽  
Vol 35 (5) ◽  
pp. 2206-2219 ◽  
Author(s):  
James M. Shine ◽  
Glenda M. Halliday ◽  
Moran Gilat ◽  
Elie Matar ◽  
Samuel J. Bolitho ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Attentional Control ◽  
Control Networks
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