Visual misperceptions and hallucinations in Parkinson's disease: Dysfunction of attentional control networks?

2011 ◽  
Vol 26 (12) ◽  
pp. 2154-2159 ◽  
Author(s):  
James M. Shine ◽  
Glenda M. Halliday ◽  
Sharon L. Naismith ◽  
Simon J.G. Lewis
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Attentional Control ◽  
Control Networks

scholarly journals The role of dysfunctional attentional control networks in visual misperceptions in Parkinson's disease

2013 ◽  
Vol 35 (5) ◽  
pp. 2206-2219 ◽  
Author(s):  
James M. Shine ◽  
Glenda M. Halliday ◽  
Moran Gilat ◽  
Elie Matar ◽  
Samuel J. Bolitho ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Attentional Control ◽  
Control Networks

scholarly journals Top–Down Attentional Control in Parkinson's Disease: Salient Considerations

2010 ◽  
Vol 22 (5) ◽  
pp. 848-859 ◽  
Author(s):  
Roshan Cools ◽  
Robert Rogers ◽  
Roger A. Barker ◽  
Trevor W. Robbins
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Attentional Control ◽  
Direct Evidence ◽  
Control Mechanisms ◽  
Set Shifting ◽  
Top Down ◽  
Bottom Up ◽  
Salient Dimension ◽  
Dimensional Salience

Cognitive dysfunction in Parkinson's disease (PD) has been hypothesized to reflect a failure of cortical control. In keeping with this hypothesis, some of the cognitive deficits in PD resemble those seen in patients with lesions in the lateral pFC, which has been associated with top–down attentional control. However, there is no direct evidence for a failure of top–down control mechanisms in PD. Here we fill this gap by demonstrating disproportionate control by bottom–up attention to dimensional salience during attentional set shifting. Patients needed significantly more trials to criterion than did controls when shifting to a low-salient dimension while, remarkably, needing significantly fewer trials to criterion than did controls when shifting to a high-salient dimension. Thus, attention was captured by bottom–up attention to salient information to a greater extent in patients than in controls. The results provide a striking reinterpretation of prior set-shifting data and provide the first direct evidence for a failure of top–down attentional control, resembling that seen after catecholamine depletion in the pFC.

scholarly journals Attentional control in Parkinson's disease is dependent on COMT val158met genotype

Brain ◽  
2008 ◽  
Vol 131 (2) ◽  
pp. 397-408 ◽  
Author(s):  
C. H. Williams-Gray ◽  
A. Hampshire ◽  
R. A. Barker ◽  
A. M. Owen
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Attentional Control ◽  
Comt Val158met

ERRATA

2002 ◽  
Vol 8 (4) ◽  
pp. 604-605
Author(s):  
M. LÉVESQUE ◽  
S. LEMAY ◽  
S. CHOUINARD ◽  
P. BLANCHET ◽  
M.-A. BÉDARD ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
African American ◽  
Executive Function ◽  
Attentional Control ◽  
Neuropsychological Tests ◽  
Reading Level ◽  
Cambridge University ◽  
Friday Morning ◽  
Age Range

First erratum: The following is a correction for an error that occurred in the Journal of the International Neuropsychological Society, Vol. 8, No. 2. An abstract titled “Parkinson's Disease Affects the Attentional Control of Unpracticed Movements,” by M. Lévesque, S. Lemay, S. Chouinard, P. Blanchet, M.-A. Bédard, and F. Richer, was accidently left out. This abstract was supposed to appear on p. 230 after C. Boulet et al., in the Executive Function subsection of Poster 4, which was a part of the Friday Morning, February 16, group of sessions.Second erratum: The following is a correction for an error that occurred in Journal of the International Neuropsychological Society, 8:2. On page 276, the abstract at the bottom of the left column has a laterality error, and “right” was supposed to appear instead of “left.”Third erratum: The following is a correction for an error that occurred in the Journal of the International Neuropsychological Society, Vol. 8, No. 3. The error occurred in the article titled “Reading level attenuates differences in neuropsychological tests performance between African American and White Elders,” pp. 341–348, by Manly et al. On page 343, under the subheading “Reading Level,” the last line in the paragraph should state the age range as 65–74 and not 70–75 years.Cambridge University Press and the authors regret the inconvenience that these inadvertent errors may have caused.

scholarly journals Mapping brain structural differences and neuroreceptor correlates in Parkinson’s disease visual hallucinations: a mega-analysis

2021 ◽  
Author(s):  
Miriam Vignando ◽  
Dominic ffytche ◽  
Simon Lewis ◽  
Phil Hyu Lee ◽  
Seok Chung ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Empirical Bayes ◽  
Large Scale ◽  
Visual Hallucinations ◽  
Imaging Data ◽  
Control Networks ◽  
Density Maps ◽  
Cortical Regions ◽  
Cortical Involvement

Abstract Parkinson’s psychosis (PDP) describes a spectrum of symptoms that may arise in Parkinson’s disease (PD) including visual hallucinations (VH). Imaging studies investigating the neural correlates of PDP have been inconsistent in their findings, due to differences in study design and limitations of scale. Here we use empirical Bayes harmonisation to pool together structural imaging data from multiple research groups into a large-scale mega-analysis, allowing us to apply new methodological approaches to identify cortical regions and networks involved in VH and their relation to receptor binding. Differences of cortical thickness and surface area show a wider cortical involvement underlying VH than previously recognised, including primary visual cortex and its surrounds, and the hippocampus, independent of its role in cognitive decline. Structural covariance analyses point to a strong involvement of the attentional control networks in PD-VH, while associations with receptor density maps suggest neurotransmitter loss may drive the cortical changes.

scholarly journals Mapping brain structural differences and neuroreceptor correlates in Parkinson's disease visual hallucinations: a mega-analysis

2021 ◽  
Author(s):  
Miriam Vignando ◽  
Dominic ffytche ◽  
Simon Lewis ◽  
Phil Hyu Lee ◽  
Seok Jong Chung ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Empirical Bayes ◽  
Large Scale ◽  
Visual Hallucinations ◽  
Imaging Data ◽  
Control Networks ◽  
Density Maps ◽  
Cortical Regions ◽  
Cortical Involvement

Parkinson's psychosis (PDP) describes a spectrum of symptoms that may arise in Parkinson's disease (PD) including visual hallucinations (VH). Imaging studies investigating the neural correlates of PDP have been inconsistent in their findings, due to differences in study design and limitations of scale. Here we use empirical Bayes harmonisation to pool together structural imaging data from multiple research groups into a large-scale mega-analysis, allowing us to apply new methodological approaches to identify cortical regions and networks involved in VH and their relation to receptor binding. Differences of cortical thickness and surface area show a wider cortical involvement underlying VH than previously recognised, including primary visual cortex and its surrounds, and the hippocampus, independent of its role in cognitive decline. Structural covariance analyses point to a strong involvement of the attentional control networks in PD-VH, while associations with receptor density maps suggest neurotransmitter loss may drive the cortical changes.

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