The COMT Val158Met polymorphism affects the response to entacapone in Parkinson's disease: A randomized crossover clinical trial

2011 ◽  
Vol 69 (1) ◽  
pp. 111-118 ◽  
Author(s):  
Jean-Christophe Corvol ◽  
Cécilia Bonnet ◽  
Fanny Charbonnier-Beaupel ◽  
Anne-Marie Bonnet ◽  
Marie-Hélène Fiévet ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Clinical Trial ◽  
Parkinson's Disease ◽  
Comt Val158met ◽  
Val158met Polymorphism

Planning ability in Parkinson's disease is influenced by the COMT val158met polymorphism

2004 ◽  
Vol 19 (8) ◽  
pp. 885-891 ◽  
Author(s):  
Thomas Foltynie ◽  
Terry E. Goldberg ◽  
Simon G.J. Lewis ◽  
Andrew D. Blackwell ◽  
Bhaskar S. Kolachana ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Comt Val158met ◽  
Val158met Polymorphism ◽  
Planning Ability

scholarly journals Dopaminergic denervation severity depends on COMT Val158Met polymorphism in Parkinson's disease

2015 ◽  
Vol 21 (5) ◽  
pp. 471-476 ◽  
Author(s):  
Julia Muellner ◽  
Iman Gharrad ◽  
Marie-Odile Habert ◽  
Aurélie Kas ◽  
Jean-Baptiste Martini ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Comt Val158met ◽  
Val158met Polymorphism

Association of COMT Val158Met polymorphism with wearing-off susceptibility in Parkinson’s disease

2014 ◽  
Vol 36 (4) ◽  
pp. 621-623 ◽  
Author(s):  
Jianxing Liu ◽  
Pan Chen ◽  
Meihua Guo ◽  
Lechun Lu ◽  
Lihua Li
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Comt Val158met ◽  
Val158met Polymorphism ◽  
Wearing Off

COMT Val158Met polymorphism and Parkinson’s disease risk: a pooled analysis in different populations

2019 ◽  
Vol 41 (4) ◽  
pp. 319-325 ◽  
Author(s):  
Yan-chun Wang ◽  
Yao-bing Zou ◽  
Jing Xiao ◽  
Cheng-de Pan ◽  
Si-de Jiang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Disease Risk ◽  
Pooled Analysis ◽  
Comt Val158met ◽  
Val158met Polymorphism ◽  
Different Populations

scholarly journals Attentional control in Parkinson's disease is dependent on COMT val158met genotype

Brain ◽  
2008 ◽  
Vol 131 (2) ◽  
pp. 397-408 ◽  
Author(s):  
C. H. Williams-Gray ◽  
A. Hampshire ◽  
R. A. Barker ◽  
A. M. Owen
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Attentional Control ◽  
Comt Val158met

Dance Rhythms Improve Motor Symptoms in Individuals with Parkinson’s Disease: A Randomized Clinical Trial

2021 ◽  
Author(s):  
Jéssica A. Moratelli ◽  
Kettlyn H. Alexandre ◽  
Leonessa Boing ◽  
Alessandra Swarowsky ◽  
Clynton L. Corrêa ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Clinical Trial ◽  
Parkinson's Disease ◽  
Randomized Clinical Trial ◽  
Rating Scale ◽  
Freezing Of Gait ◽  
Motor Symptoms ◽  
Score Change ◽  
Significant Difference ◽  
Binary Group

Background: Evidence-based practices involving dance modalities found in binary (two-beat rhythm) or quaternary (four-beat rhythm) show that dance positively influences the motor aspects of disease.Aim: This randomized clinical trial aimed to analyze the effect of two dance rhythm (binary and quaternary) on the balance, gait, and mobility in individuals with Parkinson’s disease (PD). Methods: Thirty-one individuals with PD were randomized into the binary group (n = 18) and the quaternary group (n = 13). Both groups participated in different dance rhythms lasting 12 weeks, twice a week, for 45 minutes. Results: The binary group showed a significant difference in balance (p = 0.003), freezing of gait (p = 0.007), as well as in the motor aspects of MDS-Unified Parkinson’s Disease Rating Scale (MDS-UPDRS), with emphasis on the total values with a score change of 3.23. In the quaternary group, significant differences were found in balance (p = 0.021) with a score change of -2.54 and in the motor aspects of the MDS-UPDRS Part III where the total values stood out with a change of 3.54. Discussion: When comparing the possible effects of binary and quaternary rhythms on the motor symptoms of individuals with PD, it was demonstrated that binary rhythm improved balance, freezing gait, and UPDRSIII. As for the quaternary rhythm, the benefits were in balance and the UPDRSIII. Conclusion: The binary and the quaternary rhythm dance protocols positively influenced the motor symptoms of individuals with PD after 12 weeks of intervention.

Neuropsychological Effects of Deep Brain Stimulation in Subjects with Early Stage Parkinson's Disease in a Randomized Clinical Trial

2015 ◽  
Vol 5 (1) ◽  
pp. 151-163 ◽  
Author(s):  
Michael G. Tramontana ◽  
Anna L. Molinari ◽  
Peter E. Konrad ◽  
Thomas L. Davis ◽  
Scott A. Wylie ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Clinical Trial ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Randomized Clinical Trial ◽  
Brain Stimulation ◽  
Early Stage ◽  
Neuropsychological Effects ◽  
Deep Brain
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