The Effects of Intermittent Hydrostatic Pressure on Self-Assembled Articular Cartilage Constructs

2006 ◽  
Vol 0 (0) ◽  
pp. 060510114812001 ◽  
Author(s):  
Jerry C. Hu ◽  
Kyriacos A. Athanasiou
Author(s):  
Benjamin D. Elder ◽  
Kyriacos A. Athanasiou

It has previously been demonstrated that hydrostatic pressure (HP) enhances the biochemical properties of self-assembled articular cartilage constructs [1]. However, studies that systematically assess the effects of HP magnitude and frequency are lacking. Additionally, studies examining the combined effects of hydrostatic pressure and growth factors are limited. To this end, this study sought to test the hypotheses that static HP will have the greatest enhancement of construct biomechanical and biochemical properties, and that there will be additive or synergistic effects when combining growth factors and HP stimulation.


2018 ◽  
Vol 63 (9) ◽  
pp. 1311-1315 ◽  
Author(s):  
A. Krylov ◽  
S. Krylova ◽  
S. Kopyl ◽  
A. Kholkin

2009 ◽  
Vol 246 (3) ◽  
pp. 482-485 ◽  
Author(s):  
J. S. Reparaz ◽  
A. Bernardi ◽  
A. R. Goñi ◽  
M. I. Alonso ◽  
M. Garriga

2019 ◽  
Vol 13 (4) ◽  
pp. 637-648 ◽  
Author(s):  
Anne K. Haudenschild ◽  
Benjamin E. Sherlock ◽  
Xiangnan Zhou ◽  
Jerry C. Hu ◽  
J. Kent Leach ◽  
...  

2019 ◽  
Vol 71 (4) ◽  
Author(s):  
Shaobao Liu ◽  
Ru Tao ◽  
Ming Wang ◽  
Jin Tian ◽  
Guy M. Genin ◽  
...  

Hydrostatic pressure (HP) regulates diverse cell behaviors including differentiation, migration, apoptosis, and proliferation. Abnormal HP is associated with pathologies including glaucoma and hypertensive fibrotic remodeling. In this review, recent advances in quantifying and predicting how cells respond to HP across several tissue systems are presented, including tissues of the brain, eye, vasculature and bladder, as well as articular cartilage. Finally, some promising directions on the study of cell behaviors regulated by HP are proposed.


2006 ◽  
Vol 18 (6) ◽  
pp. 1877-1884 ◽  
Author(s):  
C A Duque ◽  
N Porras-Montenegro ◽  
Z Barticevic ◽  
M Pacheco ◽  
L E Oliveira

2001 ◽  
Vol 34 (7) ◽  
pp. 941-949 ◽  
Author(s):  
Ute Hansen ◽  
Michael Schünke ◽  
Christian Domm ◽  
Niki Ioannidis ◽  
Joachim Hassenpflug ◽  
...  

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