A novel angiotensin-converting enzyme inhibitory peptide from rabbit meat protein hydrolysate: Identification, molecular mechanism, and antihypertensive effect in vivo

2021 ◽  
Author(s):  
Junbo Chen ◽  
Xiaodong Yu ◽  
Wangxiang Huang ◽  
Chen Wang ◽  
Qiyi He
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Antihypertensive Effect ◽  
Protein Hydrolysate ◽  
Converting Enzyme ◽  
Inhibitory Effects ◽  
Inhibitory Peptide ◽  
Rabbit Meat ◽  
Natural Foods ◽  
Ace Inhibitory

Bioactive peptides exhibiting angiotensin-converting enzyme (ACE) inhibitory effects and extracted from natural foods have potential as healthy and safe therapeutics for high blood pressure. A novel ACE inhibitory tetrapeptide Trp-Gly-Ala-Pro...

scholarly journals Long-Term Antihypertensive Effect of Angiotensin-Converting Enzyme Inhibitory Peptide LAP

2011 ◽  
Vol 34 (5) ◽  
pp. 358-364 ◽  
Author(s):  
Luo Ming ◽  
Shen Yi ◽  
Liu Chi ◽  
Huan Zheng ◽  
Zhanxia Li ◽  
...  
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Antihypertensive Effect ◽  
Converting Enzyme ◽  
Inhibitory Peptide

Evaluation of the osteoprotective potential of whey derived-antioxidative (YVEEL) and angiotensin-converting enzyme inhibitory (YLLF) bioactive peptides in ovariectomised rats

2018 ◽  
Vol 9 (9) ◽  
pp. 4791-4801 ◽  
Author(s):  
Masum Pandey ◽  
Suman Kapila ◽  
Rajeev Kapila ◽  
Ritu Trivedi ◽  
Anirudh Karvande
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Bioactive Peptides ◽  
Converting Enzyme ◽  
Inhibitory Peptide ◽  
Ace Inhibitory Peptide ◽  
Antioxidative Peptide ◽  
Ace Inhibitory ◽  
Ovariectomised Rats

Whey-derived antioxidative peptide showed an enhanced osteoprotective effect as compared to ACE inhibitory peptide.

scholarly journals The Potential of Hydrolysate from Rabbit Meat Protein as an Angiotensin Converting Enzyme Inhibitor

2019 ◽  
Vol 43 (1) ◽  
Author(s):  
Edy Permadi ◽  
Jamhari Jamhari ◽  
Edi Suryanto ◽  
Zaenal Bachruddin ◽  
Yuny Erwanto
Keyword(s):  
Molecular Weight ◽  
Angiotensin Converting Enzyme ◽  
Soluble Protein ◽  
Ace Inhibitor ◽  
Water Soluble ◽  
Converting Enzyme ◽  
Soluble Protein Content ◽  
Water Soluble Protein ◽  
Rabbit Meat ◽  
Ace Inhibitory

This research aimed to investigate the rabbit meat hydrolysate potential as an angiotensin-converting enzyme (ACE) inhibitor. Indonesian local rabbit meats were used in this study. The research was conducted in Department of Animal Product Technology, Faculty of Animal Science, Universitas Gadjah Mada, from August 2016 to February 2017. The local rabbit meats were hydrolyzed by pepsin, trypsin, and pancreatic. The obtained hydrolysates were then analyzed to identify the water-soluble protein content. The molecular weight of the hydrolysates were also confirmed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). The ACE inhibitory properties of the hydrolysates were analyzed in vitro. The results showed that pepsin, trypsin, and pancreatic hydrolysis showed a significant effect on the water-soluble protein content of rabbit meat (p<0.05). The water-soluble protein of rabbit meat hydrolysed by pepsin, trypsin, and pancreatic were 9.41, 7.66, and 9.75 mg/mL respectively. The molecular weight of the rabbit meat hydrolysate were increased from 10 to 43 kDa; 17 to 43 kDa; and 10 to 43 kDa, after hydrolysed by by pepsin, trypsin, and pancreatic respectively. Furthermore, the ACE inhibitory properties ) of the hydrolysed rabbit meat by pepsin, trypsin, and pancreatic were 439, 170, and 380 μg/mL, respectively. The rabbit meat hydrolysate showed a potential to be ACE inhibitor after hydrolyzed with pepsin, trypsin and pancreatic. Moreover, it also showed a promising potential to be used as bioactive components in different pharmaceutical applications. The highest ACE inhibitory capability was showed on trypsin hydrolysis with the total of 65.45% and 170 μg/mL ACE inhibition

Bioactive Properties of Protein Hydrolysate of Cottonseed Byproduct: Antioxidant, Antimicrobial, and Angiotensin-Converting Enzyme (ACE) Inhibitory Activities

2020 ◽  
Author(s):  
Josemar Gonçalves de Oliveira Filho ◽  
Juliana Moraes Rodrigues ◽  
Anna Carolina Fernandes Valadares ◽  
Adrielle Borges de Almeida ◽  
Erika Valencia-Mejia ◽  
...  
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Protein Hydrolysate ◽  
Converting Enzyme ◽  
Bioactive Properties ◽  
Inhibitory Activities ◽  
Ace Inhibitory
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