Angiotensin converting enzyme (ACE) inhibitory and antihypertensive activities of protein hydrolysate from meat of Kacang goat (Capra aegagrus hircus )

2016 ◽  
Vol 96 (10) ◽  
pp. 3536-3542 ◽  
Author(s):  
Irdha Mirdhayati ◽  
Joko Hermanianto ◽  
Christofora H Wijaya ◽  
Dondin Sajuthi ◽  
Keizo Arihara
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Protein Hydrolysate ◽  
Converting Enzyme ◽  
Capra Aegagrus ◽  
Ace Inhibitory

Bioactive Properties of Protein Hydrolysate of Cottonseed Byproduct: Antioxidant, Antimicrobial, and Angiotensin-Converting Enzyme (ACE) Inhibitory Activities

2020 ◽  
Author(s):  
Josemar Gonçalves de Oliveira Filho ◽  
Juliana Moraes Rodrigues ◽  
Anna Carolina Fernandes Valadares ◽  
Adrielle Borges de Almeida ◽  
Erika Valencia-Mejia ◽  
...  
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Protein Hydrolysate ◽  
Converting Enzyme ◽  
Bioactive Properties ◽  
Inhibitory Activities ◽  
Ace Inhibitory

scholarly journals Bioactive properties of protein hydrolysate of cottonseed byproduct: antioxidant, antimicrobial, and angiotensin‐converting enzyme (ACE) inhibitory activity

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Mariana Buranelo Egea ◽  
Josemar Gonçalves de Oliveira Filho ◽  
Ailton Cesar Lemes ◽  
Erika Valencia-Mejia ◽  
Katia Flavia Fernandes ◽  
...  
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Inhibitory Activity ◽  
Protein Hydrolysate ◽  
Converting Enzyme ◽  
Ace Inhibitory Activity ◽  
Bioactive Properties ◽  
Ace Inhibitory

scholarly journals Spent Hen Protein Hydrolysate with Good Gastrointestinal Stability and Permeability in Caco-2 Cells Shows Antihypertensive Activity in SHR

Foods ◽  
2020 ◽  
Vol 9 (10) ◽  
pp. 1384 ◽  
Author(s):  
Hongbing Fan ◽  
Wenlin Yu ◽  
Wang Liao ◽  
Jianping Wu
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Inhibitory Activity ◽  
Protein Hydrolysate ◽  
Antihypertensive Activity ◽  
Converting Enzyme ◽  
Muscle Proteins ◽  
Ace Inhibitory Activity ◽  
Spent Hen ◽  
Anti Inflammatory ◽  
Ace Inhibitory

Spent hens are a major byproduct of the egg industry but are rich in muscle proteins that can be enzymatically transformed into bioactive peptides. The present study aimed to develop a spent hen muscle protein hydrolysate (SPH) with antihypertensive activity. Spent hen muscle proteins were hydrolyzed by nine enzymes, either individually or in combination; 18 SPHs were assessed initially for their in vitro angiotensin-converting enzyme (ACE) inhibitory activity, and three SPHs, prepared by Protex 26L (SPH-26L), pepsin (SPH-P), and thermoase (SPH-T), showed promising activity and peptide yield. These three hydrolysates were further assessed for their angiotensin-converting enzyme 2 (ACE2) upregulating, antioxidant, and anti-inflammatory activities; only SPH-T upregulated ACE2 expression, while all three SPHs showed antioxidant and anti-inflammatory activities. During simulated gastrointestinal digestion, ACE2 upregulating, ACE inhibitory and antioxidant activities of SPH-T were not affected, but those of SPH-26L and SPH-P were reduced. ACE inhibitory activity of gastrointestinal-digested SPH-T was not affected after the permeability study in Caco-2 cells, while ACE2 upregulating, antioxidant and anti-inflammatory activities were improved; nine novel peptides with five–eight amino acid residues were identified from the Caco-2 permeate. Among these three hydrolysates, only SPH-T reduced blood pressure significantly when given orally at a daily dose of 1000 mg/kg body weight to spontaneously hypertensive rats. SPH-T can be developed into a promising functional food ingredient against hypertension, contributing to a more sustainable utilization for spent hens while generating extra revenue for the egg industry.

A novel angiotensin-converting enzyme inhibitory peptide from rabbit meat protein hydrolysate: Identification, molecular mechanism, and antihypertensive effect in vivo

2021 ◽  
Author(s):  
Junbo Chen ◽  
Xiaodong Yu ◽  
Wangxiang Huang ◽  
Chen Wang ◽  
Qiyi He
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Antihypertensive Effect ◽  
Protein Hydrolysate ◽  
Converting Enzyme ◽  
Inhibitory Effects ◽  
Inhibitory Peptide ◽  
Rabbit Meat ◽  
Natural Foods ◽  
Ace Inhibitory

Bioactive peptides exhibiting angiotensin-converting enzyme (ACE) inhibitory effects and extracted from natural foods have potential as healthy and safe therapeutics for high blood pressure. A novel ACE inhibitory tetrapeptide Trp-Gly-Ala-Pro...

scholarly journals Angiotensin-converting enzyme (ACE) inhibitory activity of Solanum torvum and isolation of a novel methyl salicylate glycoside

2014 ◽  
Vol 11 ◽  
pp. 557-562 ◽  
Author(s):  
Arunee Simaratanamongkol ◽  
Kaoru Umehara ◽  
Hiroki Niki ◽  
Hiroshi Noguchi ◽  
Pharkphoom Panichayupakaranant
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Inhibitory Activity ◽  
Methyl Salicylate ◽  
Converting Enzyme ◽  
Ace Inhibitory Activity ◽  
Solanum Torvum ◽  
Ace Inhibitory

scholarly journals ANGIOTENSIN CONVERTING ENZYME INHIBITORY ACTIVITY OF MELINJO (GNETUM GNEMON L.) SEED EXTRACTS AND MOLECULAR DOCKING OF ITS STILBENE CONSTITUENTS

2017 ◽  
Vol 10 (3) ◽  
pp. 243
Author(s):  
Abdul Mun'im ◽  
Muhammad Ashar Munadhil ◽  
Nuraini Puspitasari ◽  
Azminah . ◽  
Arry Yanuar
Keyword(s):  
Molecular Docking ◽  
Angiotensin Converting Enzyme ◽  
Ethyl Acetate ◽  
Inhibitory Activity ◽  
Phenolic Content ◽  
Ethyl Acetate Extract ◽  
Total Phenolic ◽  
Converting Enzyme ◽  
Gnetum Gnemon ◽  
Ace Inhibitory

ABSTRACTObjectives: To evaluate the angiotensin converting enzyme (ACE) inhibitory activity of melinjo (Gnetum gnemon) seed extract and to study moleculardocking of stilbene contained in melinjo seeds.Methods: Melinjo seed powders were extracted with n-hexane, dichloromethane, ethyl acetate, methanol, and water successively. The extracts wereevaluated ACE inhibitory activities using ACE kit-Wist and the phenolic content using Folin–Ciocalteu method. The extract demonstrated the highestACE inhibitory activity was subjected to liquid chromatography-mass spectrometry (LC-MS) to know its stilbene constituent. The stilbene constituentsin melinjo seed were performed molecular docking using AutoDock Vina, and ligand-receptor Interactions were processed using Ligand Scout.Results: The ethyl acetate extract demonstrated the highest ACE inhibition activity with inhibitory concentration 50% value of 9.77 × 10−8 μg/mLand the highest total phenolic content (575.9 mg gallic acid equivalent/g). Ultra-performance LC-MS analysis of ethyl acetate extract has detected theexistency of resveratrol, gnetin C, ε-viniferin, and gnemonoside A/B. These compounds displayed similar physiochemical properties to lisinopril (ACEinhibitor), as in silico molecular docking studies demonstrated that they fit into the lisinopril receptors.Conclusion: In vitro analysis ethyl acetate extract from melinjo seeds demonstrated the highest ACE inhibitory activity. Molecular docking analysisindicated that resveratrol dimers, gnetin C and gnemonoside A can be considered ACE inhibitor.Keywords: Angiotensin converting enzyme inhibitor, Gnetum gnemon, Melinjo, Total phenolic, Antihypertension, Molecular docking.

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