Antihypertensive Effect of Angiotensin-Converting Enzyme Inhibitory Peptide RVPSL on Spontaneously Hypertensive Rats by Regulating Gene Expression of the Renin–Angiotensin System

2014 ◽  
Vol 62 (4) ◽  
pp. 912-917 ◽  
Author(s):  
Zhipeng Yu ◽  
Yongguang Yin ◽  
Wenzhu Zhao ◽  
Feng Chen ◽  
Jingbo Liu
Keyword(s):  
Gene Expression ◽  
Angiotensin Converting Enzyme ◽  
Spontaneously Hypertensive Rats ◽  
Antihypertensive Effect ◽  
Renin Angiotensin System ◽  
Converting Enzyme ◽  
Hypertensive Rats ◽  
Inhibitory Peptide ◽  
Angiotensin System ◽  
Spontaneously Hypertensive

scholarly journals Finger Millet Ethanol Extracts Prevent Hypertension by Inhibiting the Angiotensin-Converting Enzyme Level and Enhancing the Antioxidant Capacity in Spontaneously Hypertensive Rats

Antioxidants ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 1766
Author(s):  
Se Yeong Park ◽  
Eun Woo Jeong ◽  
Yun Sun Yang ◽  
Hyun-Joo Kim ◽  
Gwang-woong Go ◽  
...  
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Spontaneously Hypertensive Rats ◽  
Finger Millet ◽  
Renin Angiotensin System ◽  
Converting Enzyme ◽  
Hypertensive Rats ◽  
Angiotensin System ◽  
Spontaneously Hypertensive ◽  
Renin Angiotensin ◽  
Ethanol Extracts

Finger millet (Eleusine coracana) contains high levels of calcium and polyphenols, which have a variety of beneficial functions. We tested the hypothesis that finger millet ethanol extracts (FEs) have an antihypertensive effect in spontaneously hypertensive rats (SHRs). The study groups were assigned as follows: (1) Wistar Kyoto rats (normal); (2) SHRs treated with saline (negative control); (3) SHRs treated with captopril 50 mg/kg bw (positive control); (4) SHRs treated with FE 250 mg/kg bw (FE250); and (5) SHRs treated with FE 500 mg/kg bw (FE500). FE supplementation improved the lipid profiles, including the triglyceride, total cholesterol, and low-density lipoprotein cholesterol levels, without deterioration in liver function. The thiobarbituric acid reactive substance concentration and superoxide dismutase activity significantly improved after the application of FE250 and FE500. Interestingly, FE250 and FE500 application dramatically reduced the systolic blood pressure. FE supplementation exhibited powerful control over the renin-angiotensin system by reducing the angiotensin-converting enzyme levels and renin mRNA expression in the kidney. Additionally, FE500 application ameliorated vascular remodeling, reversed the thickening media, and decreased the media thickness/lumen diameter ratio of the aorta. These results imply that FEs are a potent antihypertensive nutraceutical for regulating the renin–angiotensin system and simultaneously inhibiting oxidative stress.

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