scholarly journals Long-Term Antihypertensive Effect of Angiotensin-Converting Enzyme Inhibitory Peptide LAP

2011 ◽  
Vol 34 (5) ◽  
pp. 358-364 ◽  
Author(s):  
Luo Ming ◽  
Shen Yi ◽  
Liu Chi ◽  
Huan Zheng ◽  
Zhanxia Li ◽  
...  
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Antihypertensive Effect ◽  
Converting Enzyme ◽  
Inhibitory Peptide

A novel angiotensin-converting enzyme inhibitory peptide from rabbit meat protein hydrolysate: Identification, molecular mechanism, and antihypertensive effect in vivo

2021 ◽  
Author(s):  
Junbo Chen ◽  
Xiaodong Yu ◽  
Wangxiang Huang ◽  
Chen Wang ◽  
Qiyi He
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Antihypertensive Effect ◽  
Protein Hydrolysate ◽  
Converting Enzyme ◽  
Inhibitory Effects ◽  
Inhibitory Peptide ◽  
Rabbit Meat ◽  
Natural Foods ◽  
Ace Inhibitory

Bioactive peptides exhibiting angiotensin-converting enzyme (ACE) inhibitory effects and extracted from natural foods have potential as healthy and safe therapeutics for high blood pressure. A novel ACE inhibitory tetrapeptide Trp-Gly-Ala-Pro...

scholarly journals Local Angiotensin-Converting Enzyme 2 Gene Expression in Kidney Allografts Is Not Affected by Renin-Angiotensin-Aldosterone Inhibitors

2021 ◽  
Vol 46 (2) ◽  
pp. 245-249
Author(s):  
Monika Cahova ◽  
Martin Kveton ◽  
Vojtech Petr ◽  
David Funda ◽  
Helena Dankova ◽  
...  
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Kidney Transplant ◽  
Converting Enzyme ◽  
Transplant Recipients ◽  
Angiotensin Ii Receptor ◽  
Kidney Transplant Recipients ◽  
Angiotensin Converting Enzyme 2 ◽  
Renin Angiotensin ◽  
Receptor Blockers

<b><i>Background:</i></b> Preclinical studies suggested that pharmacological inhibition of the renin-angiotensin-aldosterone system (RAAS) by ACE inhibitors (ACEis) or angiotensin II receptor blockers (ARBs) may increase local angiotensin-converting enzyme 2 (<i>ACE2</i>) expression. <b><i>Methods:</i></b> In this study, we evaluated the effect of ACEi or ARB treatment on expression of <i>ACE2</i>, <i>ACE</i>, and <i>AGTR1</i> in 3-month protocol kidney allograft biopsies of stable patients using RT-qPCR (<i>n</i> = 48). Protein ACE2 expression was assessed using immunohistochemistry from paraffin sections. <b><i>Results:</i></b> The therapy with RAAS blockers was not associated with increased <i>ACE2, ACE</i>, or <i>ATGR1</i> expression in kidney allografts and also ACE2 protein immunohistochemistry did not reveal differences among groups. <b><i>Conclusions:</i></b> ACEis or ARBs in kidney transplant recipients do not affect local ACE2 expression. This observation supports long-term RAAS treatment in kidney transplant recipients, despite acute complications such as COVID-19 where ACE2 serves as the entry protein for infection.

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