Tunable NIR AIE-active optical materials for lipid droplet imaging in typical model organisms and photodynamic therapy

2021 ◽  
Author(s):  
Fei Zhang ◽  
Yaoming Liu ◽  
Binsheng Yang ◽  
Pengli Guan ◽  
Jie Chai ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Medical Imaging ◽  
Lipid Droplet ◽  
Optical Materials ◽  
Near Infrared ◽  
Model Organisms ◽  
Luminescent Materials ◽  
Tissue Penetration ◽  
Typical Model ◽  
Active Optical Materials

Near infrared luminescent materials with AIE features have attracted enormous attention in the areas of medical imaging and diagnostic therapeutics because of their low background fluorescence and strong tissue penetration.

scholarly journals The Use of Upconversion Nanoparticles in Prostate Cancer Photodynamic Therapy

Life ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 360
Author(s):  
Michał Osuchowski ◽  
Filip Osuchowski ◽  
Wojciech Latos ◽  
Aleksandra Kawczyk-Krupka
Keyword(s):  
Prostate Cancer ◽  
Photodynamic Therapy ◽  
Near Infrared ◽  
Diagnostic Methods ◽  
Infrared Light ◽  
Upconversion Nanoparticles ◽  
Tissue Penetration ◽  
Deep Tissue ◽  
Visible Wavelengths ◽  
Intense Research

Photodynamic Therapy (PDT) is a cancer treatment that uses light, a photosensitizer, and oxygen to destroy tumors. This article is a review of approaches to the treatment of prostate cancer applying upconversion nanoparticles (UCNPs). UCNPs have become a phenomenon that are rapidly gaining recognition in medicine. They have proven to be highly selective and specific and present a powerful tool in the diagnosis and treatment of prostate cancer. Prostate cancer is a huge health problem in Western countries. Its early detection can significantly improve patients’ prognosis, but currently used diagnostic methods leave much to be desired. Recently developed methodologies regarding UCNP research between the years 2021 and 2014 for prostate cancer PDT will also be discussed. Current limitations in PDT include tissue irradiation with visible wavelengths that have a short tissue penetration depth. PDT with the objectives to synthesize UCNPs composed of a lanthanide core with a coating of adsorbed dye that will generate fluorescence after excitation with near-infrared light to illuminate deep tissue is a subject of intense research in prostate cancer.

Polyoxomolybdate (POM) nanoclusters with radiosensitizing and scintillating properties for low dose X-ray inducible radiation-radiodynamic therapy

2020 ◽  
Vol 5 (1) ◽  
pp. 109-118 ◽  
Author(s):  
Debabrata Maiti ◽  
Jing Zhong ◽  
Zheng Zhang ◽  
Hailin Zhou ◽  
Saisai Xion ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Light Source ◽  
Low Dose ◽  
Near Infrared ◽  
Infrared Light ◽  
X Rays ◽  
Tissue Penetration ◽  
Deep Tissue ◽  
X Ray ◽  
Therapeutic Efficiency

X-rays with high deep tissue penetration could be acted as an excellent excited light source for enhanced photodynamic therapy (PDT), avoiding the weak penetration of near-infrared light and further improving the therapeutic efficiency of PDT.

A Janus upconverting nanoplatform with biodegradability for glutathione depletion, near-infrared light induced photodynamic therapy and accelerated excretion

2020 ◽  
Vol 8 (40) ◽  
pp. 9251-9257
Author(s):  
Hang Zhou ◽  
Qunying Li ◽  
Xi Cheng ◽  
Chao Zhang ◽  
Jiawei Sun ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Near Infrared ◽  
Glutathione Depletion ◽  
Infrared Light ◽  
Oxygen Species ◽  
Tissue Penetration ◽  
Excitation Light ◽  
The Poor

The major limitations of photodynamic therapy (PDT) are the poor tissue penetration of excitation light and the neutralization of reactive oxygen species (ROS) generated by overexpressed glutathione (GSH) in cancer cells.

Construction of a near-infrared responsive upconversion nanoplatform against hypoxic tumors via NO-enhanced photodynamic therapy

Nanoscale ◽  
2020 ◽  
Vol 12 (14) ◽  
pp. 7875-7887 ◽  
Author(s):  
Ying Lan ◽  
Xiaohui Zhu ◽  
Ming Tang ◽  
Yihan Wu ◽  
Jing Zhang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Near Infrared ◽  
Upconversion Nanoparticles

A near-infrared (NIR) activated theranostic nanoplatform based on upconversion nanoparticles (UCNPs) is developed in order to overcome the hypoxia-associated resistance in photodynamic therapy by photo-release of NO upon NIR illumination.

A nitroreductase-activatable near-infrared theranostic photosensitizer for photodynamic therapy under mild hypoxia

2020 ◽  
Vol 56 (43) ◽  
pp. 5819-5822
Author(s):  
Jing Zheng ◽  
Yongzhuo Liu ◽  
Fengling Song ◽  
Long Jiao ◽  
Yingnan Wu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Triplet State ◽  
Near Infrared ◽  
Mild Hypoxia

In this study, a near-infrared (NIR) theranostic photosensitizer was developed based on a heptamethine aminocyanine dye with a long-lived triplet state.

Nanocarriers for Photodynamic Therapy Intended to Cutaneous Tumors

2021 ◽  
Vol 22 ◽  
Author(s):  
Maria Bernadete Riemma Pierre
Keyword(s):  
Photodynamic Therapy ◽  
Drug Delivery Systems ◽  
Active Agent ◽  
Therapeutic Modality ◽  
Tissue Penetration ◽  
Promising Tool ◽  
Skin Cancers ◽  
Superficial Basal Cell Carcinoma ◽  
The Stability ◽  
Disor Ders

Abstract: Photodynamic Therapy (PDT) is a therapeutic modality used for several malignant and premalignant skin disor-ders, including Bowen's disease skin cancers and Superficial Basal Cell Carcinoma (BCC). Several photosensitizers (PSs) have been explored for tumor destruction of skin cancers, after their activation by a light source of appropriate wavelength. Topical release of PSs avoids prolonged photosensitization reactions associated with systemic administration; however, its clinical usefulness is influenced by its poor tissue penetration and the stability of the active agent. Nanotechnology-based drug delivery systems are promising tool to enhance the efficiency for PDT of cancer. This review focuses on PSs encap-sulated in nanocarriers explored for PDT of skin tumors.

Near‐Infrared‐II Nanomaterials for Fluorescence Imaging and Photodynamic Therapy

2021 ◽  
pp. 2002177
Author(s):  
Hongxin Lin ◽  
Zexi Lin ◽  
Konghua Zheng ◽  
Chenlu Wang ◽  
Lisheng Lin ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Fluorescence Imaging ◽  
Near Infrared

Multi-Site Cr3+ Occupation Related Broadband NIR Luminescence in Cr3+-doped Li3Mg2NbO6

CrystEngComm ◽  
2021 ◽  
Author(s):  
Fen Xiao ◽  
Chengning Xie ◽  
Shikun Xie ◽  
Rongxi Yi ◽  
Huiling Yuan ◽  
...  
Keyword(s):  
Near Infrared ◽  
Nir Spectroscopy ◽  
Luminescent Materials ◽  
Optical Source ◽  
Nir Emission ◽  
Nir Luminescence

Broadband near infrared (NIR) luminescent materials have attracted great attention recently for the advance smart optical source of NIR spectroscopy. In this work, a broadband NIR emission from 650 nm...

Lysosomal targeted NIR photosensitizer for photodynamic therapy and two-photon fluorescent imaging

2021 ◽  
Author(s):  
Ruiyuan Liu ◽  
Yuping Zhou ◽  
Di Zhang ◽  
Genghan He ◽  
Chuang Liu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Fluorescence Imaging ◽  
Near Infrared ◽  
Fluorescent Imaging ◽  
High Fidelity ◽  
Design And Synthesis ◽  
Two Photon ◽  
Two Photon Fluorescence ◽  
Photon Fluorescence

Design and synthesis of near-infrared (NIR) emissive fluorophore for imaging of organelle and photodynamic therapy has received enormous attention. Hence, NIR emissive fluorophore of high-fidelity lysosome targeting, two-photon fluorescence imaging,...

Sign in / Sign up

Export Citation Format

Share Document