A Janus upconverting nanoplatform with biodegradability for glutathione depletion, near-infrared light induced photodynamic therapy and accelerated excretion

2020 ◽  
Vol 8 (40) ◽  
pp. 9251-9257
Author(s):  
Hang Zhou ◽  
Qunying Li ◽  
Xi Cheng ◽  
Chao Zhang ◽  
Jiawei Sun ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Near Infrared ◽  
Glutathione Depletion ◽  
Infrared Light ◽  
Oxygen Species ◽  
Tissue Penetration ◽  
Excitation Light ◽  
The Poor

The major limitations of photodynamic therapy (PDT) are the poor tissue penetration of excitation light and the neutralization of reactive oxygen species (ROS) generated by overexpressed glutathione (GSH) in cancer cells.

scholarly journals Mesoporous semiconductors combined with up-conversion nanoparticles for enhanced photodynamic therapy under near infrared light

RSC Advances ◽  
2019 ◽  
Vol 9 (30) ◽  
pp. 17273-17280 ◽  
Author(s):  
Fan Yang ◽  
Jun Liu ◽  
Xue Jiang ◽  
Weiwei Wu ◽  
Zhenni Wang ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Photodynamic Therapy ◽  
Tumor Cells ◽  
Near Infrared ◽  
Tumor Therapy ◽  
Reactive Oxygen ◽  
Infrared Light ◽  
Oxygen Species ◽  
Near Infrared Light

Photodynamic therapy (PDT) is a promising and effective method for tumor therapy that relies on the reactive oxygen species (ROS) produced by photosensitizers at specific wavelengths to inhibit tumor cells.

scholarly journals Photoactivated nanomotors via aggregation induced emission for enhanced phototherapy

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Shoupeng Cao ◽  
Jingxin Shao ◽  
Hanglong Wu ◽  
Shidong Song ◽  
Maria Teresa De Martino ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Photodynamic Therapy ◽  
Near Infrared ◽  
Radiant Energy ◽  
Reactive Oxygen ◽  
Infrared Light ◽  
Oxygen Species ◽  
Directed Motion ◽  
Aggregation Induced Emission

AbstractAggregation-induced emission (AIE) has, since its discovery, become a valuable tool in the field of nanoscience. AIEgenic molecules, which display highly stable fluorescence in an assembled state, have applications in various biomedical fields—including photodynamic therapy. Engineering structure-inherent, AIEgenic nanomaterials with motile properties is, however, still an unexplored frontier in the evolution of this potent technology. Here, we present phototactic/phototherapeutic nanomotors where biodegradable block copolymers decorated with AIE motifs can transduce radiant energy into motion and enhance thermophoretic motility driven by an asymmetric Au nanoshell. The hybrid nanomotors can harness two photon near-infrared radiation, triggering autonomous propulsion and simultaneous phototherapeutic generation of reactive oxygen species. The potential of these nanomotors to be applied in photodynamic therapy is demonstrated in vitro, where near-infrared light directed motion and reactive oxygen species induction synergistically enhance efficacy with a high level of spatial control.

Plasmon-Mediated Generation of Reactive Oxygen Species from Near-Infrared Light Excited Gold Nanocages for Photodynamic Therapyin Vitro

ACS Nano ◽  
2014 ◽  
Vol 8 (7) ◽  
pp. 7260-7271 ◽  
Author(s):  
Liang Gao ◽  
Ru Liu ◽  
Fuping Gao ◽  
Yaling Wang ◽  
Xinglu Jiang ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Near Infrared ◽  
Reactive Oxygen ◽  
Infrared Light ◽  
Oxygen Species ◽  
Near Infrared Light ◽  
Gold Nanocages

Photosensitizer coated upconversion nanoparticles for triggering reactive oxygen species under 980 nm near-infrared excitation

2019 ◽  
Vol 7 (46) ◽  
pp. 7306-7313 ◽  
Author(s):  
Jinhua Wu ◽  
Shanshan Du ◽  
Yuhua Wang
Keyword(s):  
Reactive Oxygen Species ◽  
Photodynamic Therapy ◽  
Rare Earth ◽  
Near Infrared ◽  
Reactive Oxygen ◽  
Great Promise ◽  
Upconversion Nanoparticles ◽  
Oxygen Species ◽  
Infrared Excitation

Rare-earth-based upconversion nanotechnology has recently shown great promise for photodynamic therapy (PDT).

scholarly journals Molecular interaction and cellular studies on combination photodynamic therapy with rutoside for melanoma A375 cancer cells: an in vitro study

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Khatereh Khorsandi ◽  
Reza Hosseinzadeh ◽  
Elham Chamani
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Cycle ◽  
Cell Death ◽  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
Human Melanoma ◽  
Oxygen Species ◽  
Melanoma Cancer

Abstract Background Melanoma as a type of skin cancer, is associated with a high mortality rate. Therefore, early diagnosis and efficient surgical treatment of this disease is very important. Photodynamic therapy (PDT) involves the activation of a photosensitizer by light at specific wavelength that interacts with oxygen and creates singlet oxygen molecules or reactive oxygen species (ROS), which can lead to tumor cell death. Furthermore, one of the main approches in the prevention and treatment of various cancers is plant compounds application. Phenolic compounds are essential class of natural antioxidants, which play crucial biological roles such as anticancer effects. It was previously suggested that flavonoid such as rutoside could acts as pro-oxidant or antioxidant. Hence, in this study, we aimed to investigate the effect of rutoside on the combination therapy with methylene blue (MB) assisted by photodynamic treatment (PDT) using red light source (660 nm; power density: 30 mW/cm2) on A375 human melanoma cancer cells. Methods For this purpose, the A375 human melanoma cancer cell lines were treated by MB-PDT and rutoside. Clonogenic cell survival, MTT assay, and cell death mechanisms were also determined after performing the treatment. Subsequently, after the rutoside treatment and photodynamic therapy (PDT), cell cycle and intracellular reactive oxygen species (ROS) generation were measured. Results The obtained results showed that, MB-PDT and rutoside had better cytotoxic and antiprolifrative effects on A375 melanoma cancer cells compared to each free drug, whereas the cytotoxic effect on HDF human dermal fibroblast cell was not significant. MB-PDT and rutoside combination induced apoptosis and cell cycle arrest in the human melanoma cancer cell line. Intracellular ROS increased in A375 cancer cell line after the treatment with MB-PDT and rutoside. Conclusion The results suggest that, MB-PDT and rutoside could be considered as novel approaches as the combination treatment of melanoma cancer.

scholarly journals Near Infrared-Activated Dye-Linked ZnO Nanoparticles Release Reactive Oxygen Species for Potential Use in Photodynamic Therapy

Materials ◽  
2019 ◽  
Vol 13 (1) ◽  
pp. 17 ◽  
Author(s):  
Jaspreet Singh Nagi ◽  
Kenneth Skorenko ◽  
William Bernier ◽  
Wayne E. Jones ◽  
Amber L. Doiron
Keyword(s):  
Reactive Oxygen Species ◽  
Photodynamic Therapy ◽  
Near Infrared ◽  
Umbilical Vein ◽  
Particle Surface ◽  
Reactive Oxygen ◽  
Dependent Manner ◽  
Oxygen Species ◽  
Human Carcinoma ◽  
Zno Particles

Novel dye-linked zinc oxide nanoparticles (NPs) hold potential as photosensitizers for biomedical applications due to their excellent thermal- and photo-stability. The particles produced reactive oxygen species (ROS) upon irradiation with 850 nm near infrared (NIR) light in a concentration- and time-dependent manner. Upon irradiation, ROS detected in vitro in human umbilical vein endothelial cells (HUVEC) and human carcinoma MCF7 cells positively correlated with particle concentration and interestingly, ROS detected in MCF7 was higher than in HUVEC. Preferential cytotoxicity was also exhibited by the NPs as cell killing was higher in MCF7 than in HUVEC. In the absence of irradiation, dye-linked ZnO particles minimally affected the viability of cell (HUVEC) at low concentrations (<30 μg/mL), but viability significantly decreased at higher particle concentrations, suggesting a need for particle surface modification with poly (ethylene glycol) (PEG) for improved biocompatibility. The presence of PEG on particles after dialysis was indicated by an increase in size, an increase in zeta potential towards neutral, and spectroscopy results. Cell viability was improved in the absence of irradiation when cells were exposed to PEG-coated, dye-linked ZnO particles compared to non-surface modified particles. The present study shows that there is potential for biological application of dye-linked ZnO particles in photodynamic therapy.

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