Construction of a near-infrared responsive upconversion nanoplatform against hypoxic tumors via NO-enhanced photodynamic therapy

Nanoscale ◽  
2020 ◽  
Vol 12 (14) ◽  
pp. 7875-7887 ◽  
Author(s):  
Ying Lan ◽  
Xiaohui Zhu ◽  
Ming Tang ◽  
Yihan Wu ◽  
Jing Zhang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Near Infrared ◽  
Upconversion Nanoparticles

A near-infrared (NIR) activated theranostic nanoplatform based on upconversion nanoparticles (UCNPs) is developed in order to overcome the hypoxia-associated resistance in photodynamic therapy by photo-release of NO upon NIR illumination.

Photosensitizer coated upconversion nanoparticles for triggering reactive oxygen species under 980 nm near-infrared excitation

2019 ◽  
Vol 7 (46) ◽  
pp. 7306-7313 ◽  
Author(s):  
Jinhua Wu ◽  
Shanshan Du ◽  
Yuhua Wang
Keyword(s):  
Reactive Oxygen Species ◽  
Photodynamic Therapy ◽  
Rare Earth ◽  
Near Infrared ◽  
Reactive Oxygen ◽  
Great Promise ◽  
Upconversion Nanoparticles ◽  
Oxygen Species ◽  
Infrared Excitation

Rare-earth-based upconversion nanotechnology has recently shown great promise for photodynamic therapy (PDT).

Transferrin-coated magnetic upconversion nanoparticles for efficient photodynamic therapy with near-infrared irradiation and luminescence bioimaging

Nanoscale ◽  
2017 ◽  
Vol 9 (31) ◽  
pp. 11214-11221 ◽  
Author(s):  
Dan Wang ◽  
Lin Zhu ◽  
Yuan Pu ◽  
Jie-Xin Wang ◽  
Jian-Feng Chen ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Magnetic Force ◽  
Near Infrared ◽  
Infrared Light ◽  
Upconversion Nanoparticles ◽  
Infrared Irradiation ◽  
Near Infrared Light

A novel platform based on transferrin coated magnetic upconversion nanoparticles was developed for near-infrared light induced imaging and photodynamic therapy with enhanced efficiency by magnetic force.

Near-infrared-triggered antibacterial and antifungal photodynamic therapy based on lanthanide-doped upconversion nanoparticles

Nanoscale ◽  
2018 ◽  
Vol 10 (33) ◽  
pp. 15485-15495 ◽  
Author(s):  
Yuxiang Zhang ◽  
Ping Huang ◽  
Dong Wang ◽  
Jincan Chen ◽  
Wenzhen Liu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Near Infrared ◽  
Upconversion Nanoparticles ◽  
Antimicrobial Photodynamic Therapy ◽  
Antibacterial And Antifungal

A nanocomposite coupled with a photosensitizer (CPZ) and polyvinylpyrrolidone (PVP) based on LiYF4:Yb/Er upconversion nanoparticles (UCNPs) was developed for efficient antimicrobial photodynamic therapy.

Imaging-Guided pH-Sensitive Photodynamic Therapy Using Charge Reversible Upconversion Nanoparticles under Near-Infrared Light

2013 ◽  
Vol 23 (24) ◽  
pp. 3077-3086 ◽  
Author(s):  
Chao Wang ◽  
Liang Cheng ◽  
Yumeng Liu ◽  
Xiaojing Wang ◽  
Xinxing Ma ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Near Infrared ◽  
Ph Sensitive ◽  
Infrared Light ◽  
Upconversion Nanoparticles ◽  
Near Infrared Light

The use of surface-modified upconversion nanoparticles for near-infrared-activated photodynamic therapy of oral cancer

2015 ◽  
Vol 12 (3) ◽  
pp. 371 ◽  
Author(s):  
Patricia SP Thong ◽  
Ramaswamy Bhuvaneswari ◽  
Pui-Haan Chang ◽  
Kar-Perng Low ◽  
Niagara M Idris ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Oral Cancer ◽  
Near Infrared ◽  
Upconversion Nanoparticles ◽  
Surface Modified

scholarly journals Embedded Upconversion Nanoparticles in Magnetic Molecularly Imprinted Polymers for Photodynamic Therapy of Hepatocellular Carcinoma

Biomedicines ◽  
2021 ◽  
Vol 9 (12) ◽  
pp. 1923
Author(s):  
Cheng-Chih Lin ◽  
Hung-Yin Lin ◽  
James L. Thomas ◽  
Jia-Xin Yu ◽  
Chien-Yu Lin ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Molecularly Imprinted Polymers ◽  
Near Infrared ◽  
Malignant Tumors ◽  
Peptide Sequence ◽  
Upconversion Nanoparticles ◽  
Continuous Administration ◽  
Molecularly Imprinted ◽  
Imprinted Polymers

Programmed death-ligand 1 protein (PD-L1) is often expressed in various malignant tumors; thus, it is an appropriate marker for targeted cancer therapies. Photodynamic therapy (PDT) uses light and photosensitizers to create singlet oxygen to kill cells. An important approach to PDT is the use of upconversion nanoparticles (UCNPs) to convert near-infrared (NIR) light, which penetrates tissues well, into visible light, allowing PDT to be effective at greater tissue depths. In this work, high-temperature pyrolysis was used to prepare both the core and shell of lanthanide-doped UCNPs with lithium yttrium tetrafluoride (LiYF4) to enhance the green luminescence. The photosensitizer Merocyanine 540 (MC540) was grafted onto the magnetic nanoparticles, and then one peptide sequence from PD-L1 was used as the template and imprinted onto poly(ethylene-co-vinyl alcohol) particles formed by precipitation in a non-solvent. UCNPs in the non-solvent bath were thus entrapped in the imprinted particles to generate composite nanoparticles for the targeting and photodynamic therapy of PD-L1 in tumor cells. Finally, the in vitro cytotoxicity of the nanoparticles in HepG2 human liver cancer cells was evaluated with the continuous administration of MC540/MNPs@MIPs/UCNPs under irradiation by an NIR laser. To understand the delivery of the UCNP-embedded molecularly imprinted polymers, the intrinsic and extrinsic pathways were also investigated.

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