scholarly journals The Use of Upconversion Nanoparticles in Prostate Cancer Photodynamic Therapy

Life ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 360
Author(s):  
Michał Osuchowski ◽  
Filip Osuchowski ◽  
Wojciech Latos ◽  
Aleksandra Kawczyk-Krupka
Keyword(s):  
Prostate Cancer ◽  
Photodynamic Therapy ◽  
Near Infrared ◽  
Diagnostic Methods ◽  
Infrared Light ◽  
Upconversion Nanoparticles ◽  
Tissue Penetration ◽  
Deep Tissue ◽  
Visible Wavelengths ◽  
Intense Research

Photodynamic Therapy (PDT) is a cancer treatment that uses light, a photosensitizer, and oxygen to destroy tumors. This article is a review of approaches to the treatment of prostate cancer applying upconversion nanoparticles (UCNPs). UCNPs have become a phenomenon that are rapidly gaining recognition in medicine. They have proven to be highly selective and specific and present a powerful tool in the diagnosis and treatment of prostate cancer. Prostate cancer is a huge health problem in Western countries. Its early detection can significantly improve patients’ prognosis, but currently used diagnostic methods leave much to be desired. Recently developed methodologies regarding UCNP research between the years 2021 and 2014 for prostate cancer PDT will also be discussed. Current limitations in PDT include tissue irradiation with visible wavelengths that have a short tissue penetration depth. PDT with the objectives to synthesize UCNPs composed of a lanthanide core with a coating of adsorbed dye that will generate fluorescence after excitation with near-infrared light to illuminate deep tissue is a subject of intense research in prostate cancer.

Polyoxomolybdate (POM) nanoclusters with radiosensitizing and scintillating properties for low dose X-ray inducible radiation-radiodynamic therapy

2020 ◽  
Vol 5 (1) ◽  
pp. 109-118 ◽  
Author(s):  
Debabrata Maiti ◽  
Jing Zhong ◽  
Zheng Zhang ◽  
Hailin Zhou ◽  
Saisai Xion ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Light Source ◽  
Low Dose ◽  
Near Infrared ◽  
Infrared Light ◽  
X Rays ◽  
Tissue Penetration ◽  
Deep Tissue ◽  
X Ray ◽  
Therapeutic Efficiency

X-rays with high deep tissue penetration could be acted as an excellent excited light source for enhanced photodynamic therapy (PDT), avoiding the weak penetration of near-infrared light and further improving the therapeutic efficiency of PDT.

Application of lanthanide-doped upconversion nanoparticles for cancer treatment: a review

Nanomedicine ◽  
2021 ◽  
Author(s):  
Yu-Qi Liu ◽  
Li-Ying Qin ◽  
Hong-Jiao Li ◽  
Yi-Xi Wang ◽  
Rui Zhang ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Uv Light ◽  
Infrared Light ◽  
Upconversion Nanoparticles ◽  
Tissue Penetration ◽  
Deep Tissue ◽  
Chemotherapy Drugs ◽  
New Ideas

With the excellent ability to transform near-infrared light to localized visible or UV light, thereby achieving deep tissue penetration, lanthanide ion-doped upconversion nanoparticles (UCNP) have emerged as one of the most striking nanoscale materials for more effective and safer cancer treatment. Up to now, UCNPs combined with photosensitive components have been widely used in the delivery of chemotherapy drugs, photodynamic therapy and photothermal therapy. Applications in these directions are reviewed in this article. We also highlight microenvironmental tumor monitoring and precise targeted therapies. Then we briefly summarize some new trends and the existing challenges for UCNPs. We hope this review can provide new ideas for future cancer treatment based on UCNPs.

Transferrin-coated magnetic upconversion nanoparticles for efficient photodynamic therapy with near-infrared irradiation and luminescence bioimaging

Nanoscale ◽  
2017 ◽  
Vol 9 (31) ◽  
pp. 11214-11221 ◽  
Author(s):  
Dan Wang ◽  
Lin Zhu ◽  
Yuan Pu ◽  
Jie-Xin Wang ◽  
Jian-Feng Chen ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Magnetic Force ◽  
Near Infrared ◽  
Infrared Light ◽  
Upconversion Nanoparticles ◽  
Infrared Irradiation ◽  
Near Infrared Light

A novel platform based on transferrin coated magnetic upconversion nanoparticles was developed for near-infrared light induced imaging and photodynamic therapy with enhanced efficiency by magnetic force.

Imaging-Guided pH-Sensitive Photodynamic Therapy Using Charge Reversible Upconversion Nanoparticles under Near-Infrared Light

2013 ◽  
Vol 23 (24) ◽  
pp. 3077-3086 ◽  
Author(s):  
Chao Wang ◽  
Liang Cheng ◽  
Yumeng Liu ◽  
Xiaojing Wang ◽  
Xinxing Ma ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Near Infrared ◽  
Ph Sensitive ◽  
Infrared Light ◽  
Upconversion Nanoparticles ◽  
Near Infrared Light

MnFe2O4-decorated large-pore mesoporous silica-coated upconversion nanoparticles for near-infrared light-induced and O2 self-sufficient photodynamic therapy

Nanoscale ◽  
2019 ◽  
Vol 11 (31) ◽  
pp. 14654-14667 ◽  
Author(s):  
Binbin Ding ◽  
Shuai Shao ◽  
Haihua Xiao ◽  
Chunqiang Sun ◽  
Xuechao Cai ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Mesoporous Silica ◽  
Near Infrared ◽  
Infrared Light ◽  
Upconversion Nanoparticles ◽  
Near Infrared Light ◽  
Large Pore

Upconversion hybrid theranostic nanoplatform for near-infrared light-induced and O2 self-sufficient photodynamic therapy.

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