scholarly journals Human red blood cell behaviour in hydroxyethyl starch: probed by single cell spectroscopy

RSC Advances ◽  
2020 ◽  
Vol 10 (52) ◽  
pp. 31453-31462
Author(s):  
Mithun N ◽  
Jijo Lukose ◽  
Shamee Shastry ◽  
Ganesh Mohan ◽  
Santhosh Chidangil
Keyword(s):  
Blood Cell ◽  
Single Cell ◽  
Hydroxyethyl Starch ◽  
Red Blood Cell ◽  
Intravenous Fluid ◽  
Cell Behaviour

Hydroxyethyl starch (HES) is a commonly used intravenous fluid in hospital settings.

scholarly journals Numerical Investigation of the Effects of Red Blood Cell Cytoplasmic Viscosity Contrasts on Single Cell and Bulk Transport Behaviour

2018 ◽  
Vol 8 (9) ◽  
pp. 1616 ◽  
Author(s):  
Mike de Haan ◽  
Gabor Zavodszky ◽  
Victor Azizi ◽  
Alfons Hoekstra
Keyword(s):  
Blood Cell ◽  
Single Cell ◽  
Red Blood Cell ◽  
Immersed Boundary ◽  
Short Time Scale ◽  
Ray Casting ◽  
Cellular Models ◽  
Viscosity Contrast ◽  
The Many ◽  
Short Time

In-silico cellular models of blood are invaluable to gain understanding about the many interesting properties that blood exhibits. However, numerical investigations that focus on the effects of cytoplasmic viscosity in these models are not very prevalent. We present a parallelised method to implement cytoplasmic viscosity for HemoCell, an open-source cellular model based on immersed boundary lattice Boltzmann methods, using an efficient ray-casting algorithm. The effects of the implementation are investigated with single-cell simulations focusing on the deformation in shear flow, the migration due to wall induced lift forces, the characteristic response time in periodic stretching and pair collisions between red blood cells and platelets. Collective transport phenomena are also investigated in many-cell simulations in a pressure driven channel flow. The simulations indicate that the addition of a viscosity contrast between internal and external fluids significantly affects the deformability of a red blood cell, which is most pronounced during very short time-scale events. Therefore, modelling the cytoplasmic viscosity contrast is important in scenarios with high velocity deformation, typically high shear rate flows.

ASPIRIN MODIFIES RED BLOOD CELL BEHAVIOUR (RBC) IN THE PLATELET-RBC INTERACTION

1987 ◽  
Author(s):  
M T Santos ◽  
J Aznar ◽  
J Valles ◽  
J L Perez-Reguejo
Keyword(s):  
Single Dose ◽  
Blood Cell ◽  
Platelet Activation ◽  
Red Blood Cell ◽  
Normal Subjects ◽  
Antithrombotic Agent ◽  
Cell Behaviour ◽  
Insight Into

RBC stimulate the initial stages of platelet activation by collagen as evaluated by the BASIC wave (Perez-Requejo et al. Thromb Haemostas 54:799 1985). In order to get some insight into the mechanisms of platelet-RBC interactions, a BASIC wave was induced by lug/ml of collagen after mixing "in vitro" platelets and RBC obtained both before and two hours after a single dose of 500 mg of ASA from normal subjects. The TXB2 formed was also evaluated. The results show (Table) that non aspirinized RBC (non-ASA-RBC) increase the BASIC wave intensity of aspirinized platelets (ASA-PRP) by a cyclooxygenase-independent pathway since no increase in TXB2 was observed (Exp 1), while both non-ASA-RBC (Exp 2) and ASA-RBC (Exp 3) activate non-ASA platelets with theparticipation of the cyclooxygenase system, since an increase in TXA2 was found.A comparison of the effect of non-ASA-RBC (Exp 1) and ASA-RBC (Exp 4) on aspirinized platelets shows that ASA modifies the RBC behaviour associated with estimulation of platelets by a cyclooxygenase-independent pathway. This effect of ASA on RBC is nottransient and lasts at least 48 hours after ASA ingestion. In addition, when asmall proportion of nonASA platelets (10%) is mixed with aspirinized platelets(90%) and ASA-RBC - a situation that can be encountered "in vivo" inthe hours following ASA ingestion - the intensity of the BASIC wave is 89% of that obtained when all the platelets are non aspirinized. This RBC effect on the mixtureof ASA and nonASA platelets, may help explain the sometimes contradictory effect of ASA as an antithrombotic agent.

Efficacy of Leucocyte-Poor Red Blood Cell Suspensions Prepared by Sedimentation in Hydroxyethyl Starch

Transfusion ◽  
2003 ◽  
Vol 15 (5) ◽  
pp. 439-448 ◽  
Author(s):  
I. Dorner ◽  
J. A. Moore ◽  
J. A. Collins ◽  
L. A. Sherman ◽  
H. Chaplin
Keyword(s):  
Blood Cell ◽  
Hydroxyethyl Starch ◽  
Red Blood Cell ◽  
Cell Suspensions

Red blood cell depletion with a semiautomated system or hydroxyethyl starch sedimentation for routine cord blood banking: a comparative study

Transfusion ◽  
2005 ◽  
Vol 45 (6) ◽  
pp. 867-873 ◽  
Author(s):  
Pilar Solves ◽  
Vicente Mirabet ◽  
Dolores Planelles ◽  
Ignacio Blasco ◽  
Alfredo Perales ◽  
...  
Keyword(s):  
Blood Cell ◽  
Comparative Study ◽  
Cord Blood ◽  
Hydroxyethyl Starch ◽  
Red Blood Cell ◽  
Cell Depletion ◽  
Blood Banking ◽  
Cord Blood Banking
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