scholarly journals Single-cell evaluation of red blood cell bio-mechanical and nano-structural alterations upon chemically induced oxidative stress

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Ameya Sinha ◽  
Trang T. T. Chu ◽  
Ming Dao ◽  
Rajesh Chandramohanadas
Keyword(s):  
Oxidative Stress ◽  
Blood Cell ◽  
Single Cell ◽  
Red Blood Cell ◽  
Structural Alterations ◽  
Chemically Induced

Effects of oxidative stress on red blood cell rheology in sickle cell patients

2014 ◽  
Vol 166 (4) ◽  
pp. 601-606 ◽  
Author(s):  
Régine Hierso ◽  
Xavier Waltz ◽  
Pierre Mora ◽  
Marc Romana ◽  
Nathalie Lemonne ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Blood Cell ◽  
Sickle Cell ◽  
Red Blood Cell ◽  
Cell Rheology

scholarly journals Numerical Investigation of the Effects of Red Blood Cell Cytoplasmic Viscosity Contrasts on Single Cell and Bulk Transport Behaviour

2018 ◽  
Vol 8 (9) ◽  
pp. 1616 ◽  
Author(s):  
Mike de Haan ◽  
Gabor Zavodszky ◽  
Victor Azizi ◽  
Alfons Hoekstra
Keyword(s):  
Blood Cell ◽  
Single Cell ◽  
Red Blood Cell ◽  
Immersed Boundary ◽  
Short Time Scale ◽  
Ray Casting ◽  
Cellular Models ◽  
Viscosity Contrast ◽  
The Many ◽  
Short Time

In-silico cellular models of blood are invaluable to gain understanding about the many interesting properties that blood exhibits. However, numerical investigations that focus on the effects of cytoplasmic viscosity in these models are not very prevalent. We present a parallelised method to implement cytoplasmic viscosity for HemoCell, an open-source cellular model based on immersed boundary lattice Boltzmann methods, using an efficient ray-casting algorithm. The effects of the implementation are investigated with single-cell simulations focusing on the deformation in shear flow, the migration due to wall induced lift forces, the characteristic response time in periodic stretching and pair collisions between red blood cells and platelets. Collective transport phenomena are also investigated in many-cell simulations in a pressure driven channel flow. The simulations indicate that the addition of a viscosity contrast between internal and external fluids significantly affects the deformability of a red blood cell, which is most pronounced during very short time-scale events. Therefore, modelling the cytoplasmic viscosity contrast is important in scenarios with high velocity deformation, typically high shear rate flows.

Indicator Characterizing Carbonyl-Dependent Modification of Erythrocytic Superoxydismutase as a Biochemical Marker of Oxidative Stress in Coronary Heart Disease

Kardiologiia ◽  
2020 ◽  
Vol 60 (5) ◽  
pp. 57-61
Author(s):  
A. K. Tikhaze ◽  
V. Ya. Kosach ◽  
V. Z. Lankin ◽  
A. A. Panferova ◽  
M. D. Smirnova
Keyword(s):  
Oxidative Stress ◽  
Heart Disease ◽  
Stress Intensity ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Oxidative Modification ◽  
Oxidative Stress Marker ◽  
Control Group ◽  
Sod Activity ◽  
Stress Marker

Aim To study the oxidative modification of red blood cell Cu,Zn superoxide dismutase (SOD) in patients with ischemic heart disease (IHD) in vivo and in vitro to substantiate the use of a new oxidative stress marker.Material and methods Red blood cell Cu,Zn SOD was measured by depression of nitrotetrazolium blue reduction by the superoxide anion generated in xanthine oxidase xanthine oxidation. Red blood cell Cu,Zn SOD was measured immunochemically. The biochemical study was performed in the control group (patients with low extremity fracture without known history of cardiovascular diseases and hyperlipidemia) and in groups of patients with acute myocardial infarction, stable angina, and decompensated heart failure. For evaluation of oxidative stress intensity in IHD patients, an empirical SOD oxidative modification coefficient (OMCSOD) was proposed, which is a Cu,Zn SOD activity / Cu,Zn SOD content ratio.Results The red blood cell Cu,Zn SOD activity was significantly decreased in all IHD groups compared to the control group. Furthermore, OMCSOD was also considerably decreased in IHD patients, which warrants the use of this biochemical index as an oxidative stress marker.Conclusion It was shown that the Cu,Zn SOD modification was induced by interaction of the enzyme molecules with a natural dicarbonyl, malonic dialdehyde, and OMCSOD can be used for evaluation of oxidative stress intensity in IHD patients.

scholarly journals Iron-deficiency anaemia enhances red blood cell oxidative stress

2008 ◽  
Vol 42 (9) ◽  
pp. 824-829 ◽  
Author(s):  
Enika Nagababu ◽  
Seema Gulyani ◽  
Christopher J. Earley ◽  
Roy G. Cutler ◽  
Mark P. Mattson ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Iron Deficiency ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Iron Deficiency Anaemia ◽  
Deficiency Anaemia

Storage-induced increase in biomarkers of oxidative stress and inflammation in red blood cell components

2011 ◽  
Vol 71 (4) ◽  
pp. 299-303 ◽  
Author(s):  
Bülent Kücükakin ◽  
Volkan Kocak ◽  
Jens Lykkesfeldt ◽  
Hans J. Nielsen ◽  
Karin Magnussen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Components ◽  
Biomarkers Of Oxidative Stress

Exacerbation of oxidative stress during sickle vaso-occlusive crisis is associated with decreased anti-band 3 autoantibodies rate and increased red blood cell-derived microparticle level: a prospective study

2016 ◽  
Vol 176 (5) ◽  
pp. 805-813 ◽  
Author(s):  
Régine Hierso ◽  
Nathalie Lemonne ◽  
Rinaldo Villaescusa ◽  
Marie-Laure Lalanne-Mistrih ◽  
Keyne Charlot ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Blood Cell ◽  
Prospective Study ◽  
Red Blood Cell ◽  
Band 3 ◽  
A Prospective Study

Relationships between oxidative stress markers and red blood cell characteristics in renal azotemic dogs

2009 ◽  
Vol 86 (2) ◽  
pp. 309-313 ◽  
Author(s):  
C. Buranakarl ◽  
M. Trisiriroj ◽  
S. Pondeenana ◽  
T. Tungjitpeanpong ◽  
P. Jarutakanon ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Oxidative Stress Markers ◽  
Stress Markers
Sign in / Sign up

Export Citation Format

Share Document