scholarly journals Icariin controlled release on a silk fibroin/mesoporous bioactive glass nanoparticles scaffold for promoting stem cell osteogenic differentiation

RSC Advances ◽  
2020 ◽  
Vol 10 (20) ◽  
pp. 12105-12112 ◽  
Author(s):  
Xiaofeng Shen ◽  
Pengfei Yu ◽  
Hua Chen ◽  
Jiangping Wang ◽  
Binjie Lu ◽  
...  
Keyword(s):  
Stem Cell ◽  
Controlled Release ◽  
Sustained Release ◽  
Bioactive Glass ◽  
Osteogenic Differentiation ◽  
Silk Fibroin ◽  
Mesoporous Bioactive Glass

Long-term promotion of osteogenic differentiation through silk fibroin/mesoporous bioactive glass-loaded sustained release of icariin.

scholarly journals Long-term controlled release of 125I-tagged BMP-2 by mesoporous bioactive glass with ordered nanopores

2013 ◽  
Vol 6 (6) ◽  
pp. 1443-1448 ◽  
Author(s):  
QUAN ZHANG ◽  
YE ZHANG ◽  
WENJUN CHEN ◽  
BINGWEN ZHANG ◽  
SHILONG WANG
Keyword(s):  
Controlled Release ◽  
Bioactive Glass ◽  
Mesoporous Bioactive Glass

Ions release behavior of vanadium-doped mesoporous bioactive glass particles and effect on BMSCs osteogenic differentiation via FAK/MAPK signaling pathway

2021 ◽  
Author(s):  
Jiangfeng Li ◽  
Junying Li ◽  
Yuhao Wei ◽  
Na Xu ◽  
Jingtao Li ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bioactive Glass ◽  
Osteogenic Differentiation ◽  
Bone Growth ◽  
Mapk Signaling ◽  
Release Behavior ◽  
Pentavalent Vanadium ◽  
Important Trace Element ◽  
Vanadium Ions ◽  
Mesoporous Bioactive Glass

Vanadium is an important trace element in bone to involve in bone metabolism, bone formation, and bone growth, but roles of various vanadium ions, especially pentavalent vanadium, in bone tissue...

scholarly journals Ag and Mn-doped mesoporous bioactive glass nanoparticles incorporated into the chitosan/gelatin coatings deposited on PEEK/bioactive glass layers for favorable osteogenic differentiation and antibacterial activity

2020 ◽  
Vol 1 (5) ◽  
pp. 1273-1284 ◽  
Author(s):  
Aneeqa Nawaz ◽  
Shaher Bano ◽  
Muhammad Yasir ◽  
Abdul Wadood ◽  
Muhammad Atiq Ur Rehman
Keyword(s):  
Antibacterial Activity ◽  
Bioactive Glass ◽  
Osteogenic Differentiation ◽  
Antibacterial Coatings ◽  
Orthopedic Applications ◽  
Mn Doped ◽  
Mesoporous Bioactive Glass

Multifunctional bioactive and antibacterial coatings for orthopedic applications.

Beta-cyclodextrin modified mesoporous bioactive glass nanoparticles/silk fibroin hybrid nanofibers as an implantable estradiol delivery system for the potential treatment of osteoporosis

Nanoscale ◽  
2018 ◽  
Vol 10 (38) ◽  
pp. 18341-18353 ◽  
Author(s):  
Dong Wang ◽  
Chris Steffi ◽  
Zuyong Wang ◽  
Chee Hoe Kong ◽  
Poon Nian Lim ◽  
...  
Keyword(s):  
Sustained Release ◽  
Bioactive Glass ◽  
Delivery System ◽  
Osteoporotic Bone ◽  
Potential Treatment ◽  
Treatment Of Osteoporosis ◽  
Beta Cyclodextrin ◽  
Hybrid Nanofibers ◽  
Localized Delivery ◽  
Mesoporous Bioactive Glass

A hybrid nanofibers is produced for localized delivery and sustained release of estradiol in osteoporotic bone.

The Primary Investigation on Biological Effect of Mesoporous Bioactive Glass In Vivo

2013 ◽  
Vol 750-752 ◽  
pp. 1651-1655
Author(s):  
Bai Yan Sui ◽  
Cheng Tie Wu ◽  
Jiao Sun
Keyword(s):  
Bioactive Glass ◽  
Biological Effect ◽  
Degradation Products ◽  
Long Term Effect ◽  
Liver And Kidney ◽  
Mesoporous Bioactive Glass

Mesoporous bioactive glass (MBG) has superior bioactivity and degradation than non-mesoporous bioactive glass (BG) in vitro. But the biological effect of MBG in vivo is still unknown. In this study, MBG powders with 20μm were implanted into the femoral condyles in SD rats. BG powders with 20μm were used as a control. The local degradation and osteogenesis were observed at 1 week and 4 weeks after implantation, and the systemic toxicity of the degradation products were also evaluated simultaneously. The results revealed MBG powders had the faster rate of degradation and better osteogenesis effect than BG powders at 4 weeks, although the most of material still remained in situ. Histopathological analyses indicated the degradation products did not have any damage to major organs such as liver and kidney. In conclusion, this preliminary study demonstrated that MBG powders have more excellent biological effect at 4 weeks than that of BG in vivo. However the long-term effect needs to be confirmed.

scholarly journals Incorporation of Boron in Mesoporous Bioactive Glass Nanoparticles Reduces Inflammatory Response and Delays Osteogenic Differentiation

2020 ◽  
Vol 37 (7) ◽  
pp. 2000054 ◽  
Author(s):  
Kai Zheng ◽  
Yuqian Fan ◽  
Elisa Torre ◽  
Preethi Balasubramanian ◽  
Nicola Taccardi ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Bioactive Glass ◽  
Osteogenic Differentiation ◽  
Mesoporous Bioactive Glass

SC79-loaded ZSM-5/chitosan porous scaffolds with enhanced stem cell osteogenic differentiation and bone regeneration

2017 ◽  
Vol 5 (25) ◽  
pp. 5009-5018 ◽  
Author(s):  
Rong Zhu ◽  
Yi-Xuan Chen ◽  
Qin-Fei Ke ◽  
You-Shui Gao ◽  
Ya-Ping Guo
Keyword(s):  
Stem Cell ◽  
Controlled Release ◽  
Bone Regeneration ◽  
Osteogenic Differentiation ◽  
Signaling Pathway ◽  
Porous Scaffolds ◽  
Local Bone

SC79-loaded ZSM-5/chitosan porous scaffolds were fabricated for defined local bone regeneration, and the controlled release of SC79 from therapeutic scaffolds enhanced stem cell osteogenic differentiationviathe activated Wnt/β-catenin signaling pathway.

scholarly journals Enhanced Stem Cell Osteogenic Differentiation by Bioactive Glass Functionalized Graphene Oxide Substrates

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Xiaoju Mo ◽  
Yan Wei ◽  
Xuehui Zhang ◽  
Qing Cai ◽  
Yang Shen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Graphene Oxide ◽  
Stem Cell ◽  
Bioactive Glass ◽  
Osteogenic Differentiation ◽  
Sol Gel ◽  
Functionalized Graphene ◽  
Functionalized Graphene Oxide ◽  
Different Content ◽  
Hybrid Scaffolds

An unmet need in engineered bone regeneration is to develop scaffolds capable of manipulating stem cells osteogenesis. Graphene oxide (GO) has been widely used as a biomaterial for various biomedical applications. However, it remains challenging to functionalize GO as ideal platform for specifically directing stem cell osteogenesis. Herein, we report facile functionalization of GO with dopamine and subsequent bioactive glass (BG) to enhance stem cell adhesion, spreading, and osteogenic differentiation. On the basis of graphene, we obtained dopamine functionalized graphene oxide/bioactive glass (DGO/BG) hybrid scaffolds containing different content of DGO by loading BG nanoparticles on graphene oxide surface using sol-gel method. To enhance the dispersion stability and facilitate subsequent nucleation of BG in GO, firstly, dopamine (DA) was used to modify GO. Then, the modified GO was functionalized with bioactive glass (BG) using sol-gel method. The adhesion, spreading, and osteoinductive effects of DGO/BG scaffold on rat bone marrow mesenchymal stem cells (rBMSCs) were evaluated. DGO/BG hybrid scaffolds with different content of DGO could influence rBMSCs’ behavior. The highest expression level of osteogenic markers suggests that the DGO/BG hybrid scaffolds have great potential or elicit desired bone reparative outcome.

scholarly journals Impact of Zinc- or Copper-Doped Mesoporous Bioactive Glass Nanoparticles on the Osteogenic Differentiation and Matrix Formation of Mesenchymal Stromal Cells

Materials ◽  
2021 ◽  
Vol 14 (8) ◽  
pp. 1864
Author(s):  
Fabian Westhauser ◽  
Simon Decker ◽  
Qaisar Nawaz ◽  
Felix Rehder ◽  
Sebastian Wilkesmann ◽  
...  
Keyword(s):  
Bioactive Glass ◽  
Osteogenic Differentiation ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Related Gene ◽  
Future Studies ◽  
Positive Effects ◽  
Expression Of Genes ◽  
Genes Encoding ◽  
Mesoporous Bioactive Glass

Mesoporous bioactive glass nanoparticles (MBGNs) have gained relevance in bone tissue engineering, especially since they can be used as vectors for therapeutically active ions like zinc (Zn) or copper (Cu). In this study, the osteogenic properties of the ionic dissolution products (IDPs) of undoped MBGNs (composition in mol%: 70 SiO2, 30 CaO) and MBGNs doped with 5 mol% of either Zn (5Zn-MBGNs) or Cu (5Cu-MBGNs; compositions in mol%: 70 SiO2, 25 CaO, 5 ZnO/CuO) on human bone marrow-derived mesenchymal stromal cells were evaluated. Extracellular matrix (ECM) formation and calcification were assessed, as well as the IDPs’ influence on viability, cellular osteogenic differentiation and the expression of genes encoding for relevant members of the ECM. The IDPs of undoped MBGNs and 5Zn-MBGNs had a comparable influence on cell viability, while it was enhanced by IDPs of 5Cu-MBGNs compared to the other MBGNs. IDPs of 5Cu-MBGNs had slightly positive effects on ECM formation and calcification. 5Zn-MBGNs provided the most favorable pro-osteogenic properties since they increased not only cellular osteogenic differentiation and ECM-related gene expression but also ECM formation and calcification significantly. Future studies should analyze other relevant properties of MBGNs, such as their impact on angiogenesis.

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