scholarly journals Incorporation of Boron in Mesoporous Bioactive Glass Nanoparticles Reduces Inflammatory Response and Delays Osteogenic Differentiation

2020 ◽  
Vol 37 (7) ◽  
pp. 2000054 ◽  
Author(s):  
Kai Zheng ◽  
Yuqian Fan ◽  
Elisa Torre ◽  
Preethi Balasubramanian ◽  
Nicola Taccardi ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Bioactive Glass ◽  
Osteogenic Differentiation ◽  
Mesoporous Bioactive Glass

Ions release behavior of vanadium-doped mesoporous bioactive glass particles and effect on BMSCs osteogenic differentiation via FAK/MAPK signaling pathway

2021 ◽  
Author(s):  
Jiangfeng Li ◽  
Junying Li ◽  
Yuhao Wei ◽  
Na Xu ◽  
Jingtao Li ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bioactive Glass ◽  
Osteogenic Differentiation ◽  
Bone Growth ◽  
Mapk Signaling ◽  
Release Behavior ◽  
Pentavalent Vanadium ◽  
Important Trace Element ◽  
Vanadium Ions ◽  
Mesoporous Bioactive Glass

Vanadium is an important trace element in bone to involve in bone metabolism, bone formation, and bone growth, but roles of various vanadium ions, especially pentavalent vanadium, in bone tissue...

scholarly journals Ag and Mn-doped mesoporous bioactive glass nanoparticles incorporated into the chitosan/gelatin coatings deposited on PEEK/bioactive glass layers for favorable osteogenic differentiation and antibacterial activity

2020 ◽  
Vol 1 (5) ◽  
pp. 1273-1284 ◽  
Author(s):  
Aneeqa Nawaz ◽  
Shaher Bano ◽  
Muhammad Yasir ◽  
Abdul Wadood ◽  
Muhammad Atiq Ur Rehman
Keyword(s):  
Antibacterial Activity ◽  
Bioactive Glass ◽  
Osteogenic Differentiation ◽  
Antibacterial Coatings ◽  
Orthopedic Applications ◽  
Mn Doped ◽  
Mesoporous Bioactive Glass

Multifunctional bioactive and antibacterial coatings for orthopedic applications.

scholarly journals Impact of Zinc- or Copper-Doped Mesoporous Bioactive Glass Nanoparticles on the Osteogenic Differentiation and Matrix Formation of Mesenchymal Stromal Cells

Materials ◽  
2021 ◽  
Vol 14 (8) ◽  
pp. 1864
Author(s):  
Fabian Westhauser ◽  
Simon Decker ◽  
Qaisar Nawaz ◽  
Felix Rehder ◽  
Sebastian Wilkesmann ◽  
...  
Keyword(s):  
Bioactive Glass ◽  
Osteogenic Differentiation ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Related Gene ◽  
Future Studies ◽  
Positive Effects ◽  
Expression Of Genes ◽  
Genes Encoding ◽  
Mesoporous Bioactive Glass

Mesoporous bioactive glass nanoparticles (MBGNs) have gained relevance in bone tissue engineering, especially since they can be used as vectors for therapeutically active ions like zinc (Zn) or copper (Cu). In this study, the osteogenic properties of the ionic dissolution products (IDPs) of undoped MBGNs (composition in mol%: 70 SiO2, 30 CaO) and MBGNs doped with 5 mol% of either Zn (5Zn-MBGNs) or Cu (5Cu-MBGNs; compositions in mol%: 70 SiO2, 25 CaO, 5 ZnO/CuO) on human bone marrow-derived mesenchymal stromal cells were evaluated. Extracellular matrix (ECM) formation and calcification were assessed, as well as the IDPs’ influence on viability, cellular osteogenic differentiation and the expression of genes encoding for relevant members of the ECM. The IDPs of undoped MBGNs and 5Zn-MBGNs had a comparable influence on cell viability, while it was enhanced by IDPs of 5Cu-MBGNs compared to the other MBGNs. IDPs of 5Cu-MBGNs had slightly positive effects on ECM formation and calcification. 5Zn-MBGNs provided the most favorable pro-osteogenic properties since they increased not only cellular osteogenic differentiation and ECM-related gene expression but also ECM formation and calcification significantly. Future studies should analyze other relevant properties of MBGNs, such as their impact on angiogenesis.

Mesoporous bioactive glass scaffold delivers salvianolic acid B to promote bone regeneration in a rat cranial defect model

2020 ◽  
Vol 17 ◽  
Author(s):  
Lin Wu ◽  
Zhanying Wei ◽  
Siyu He ◽  
Yunlong Bi ◽  
Yang Cao ◽  
...  
Keyword(s):  
Bioactive Glass ◽  
Bone Regeneration ◽  
Osteogenic Differentiation ◽  
Bone Defects ◽  
Salvianolic Acid B ◽  
Fluorescence Labeling ◽  
High Dose ◽  
Alizarin Red ◽  
Salvianolic Acid ◽  
Mesoporous Bioactive Glass

Background: Mesoporous bioactive glass (MBG) has been widely studied because of its excellent histocompatibility and degradability. However, due to the lack of good osteoinductive activity, the pure MBG scaffold is not effective in repairing large-scale bone defects. Objective: To observe the repair effect of MBG scaffolds delivering salvianolic acid B (SB) on critical bone defects in rats. Method: In this study, MBG scaffolds were used as delivery vehicle. SB, a small molecular active drug with good osteogenic differentiation ability, was loaded into the MBG scaffolds at low, medium and high doses. The effect of SB released from the MBG scaffolds on osteogenic differentiation of rat bone marrow mesenchymal stem cells (rBMSCs) was investigated using alkaline phosphatase staining, alizarin red staining and real-time quantitative polymerase chain reaction. Moreover, 8 weeks after implantation of the scaffolds, the bone regeneration was evaluated by micro-CT, sequential fluorescence labeling and histological staining analysis. Results: The in vitro results showed that different doses of SB had similar release rate from scaffolds and could be released from scaffolds continuously. The middle dose (MBG/MSB) and high dose (MBG/HSB) groups significantly promoted the osteogenic differentiation of rBMSCs when compared with low dose (MBG/LSB) group. Moreover, SB produced significant increases in newly formed bone of calvarial bone defects in rats. Conclusion: It’s concluded that the use of MBG scffolds delivering SB is an effective strategy for the treatment of bone defects.

scholarly journals Icariin controlled release on a silk fibroin/mesoporous bioactive glass nanoparticles scaffold for promoting stem cell osteogenic differentiation

RSC Advances ◽  
2020 ◽  
Vol 10 (20) ◽  
pp. 12105-12112 ◽  
Author(s):  
Xiaofeng Shen ◽  
Pengfei Yu ◽  
Hua Chen ◽  
Jiangping Wang ◽  
Binjie Lu ◽  
...  
Keyword(s):  
Stem Cell ◽  
Controlled Release ◽  
Sustained Release ◽  
Bioactive Glass ◽  
Osteogenic Differentiation ◽  
Silk Fibroin ◽  
Mesoporous Bioactive Glass

Long-term promotion of osteogenic differentiation through silk fibroin/mesoporous bioactive glass-loaded sustained release of icariin.

scholarly journals Anti-Microbial and Remineralizing Properties of Self-Adhesive Orthodontic Resin Containing Mesoporous Bioactive Glass

Materials ◽  
2021 ◽  
Vol 14 (13) ◽  
pp. 3550
Author(s):  
Aerin Choi ◽  
Kyung-Hyeon Yoo ◽  
Seog-Young Yoon ◽  
Bong-Soo Park ◽  
In-Ryoung Kim ◽  
...  
Keyword(s):  
Bond Strength ◽  
Physical Properties ◽  
Bioactive Glass ◽  
Shear Bond Strength ◽  
Antibacterial Effect ◽  
Gram Positive ◽  
Gram Negative ◽  
Gram Positive Bacteria ◽  
Significant Difference ◽  
Mesoporous Bioactive Glass

Self-adhesive resins (SARs) contain adhesives, which simplify the procedures of resin application, and primers, which provide sufficient bonding ability. In this study, mesoporous bioactive glass nanoparticles (MBN) were added to a SAR to easily improve the physical properties and remineralization ability. The experimental resins comprised 1%, 3%, and 5% MBN mixed in Ortho Connect Flow (GC Corp, Tokyo, Japan). As the MBN content in the SAR increased, the microhardness increased, and a statistically significant difference was observed between the cases of 1% and 5% MBN addition. Shear bond strength increased for 1% and 3% MBN samples and decreased for 5% MBN. The addition of MBN indicated a statistically significant antibacterial effect on both gram-negative and gram-positive bacteria. The anti-demineralization experiment showed that the remineralization length increased with the MBN content of the sample. Through the above results, we found that SAR containing MBN has antibacterial and remineralization effects. Thus, by adding MBN to the SAR, we investigated the possibility of orthodontic resin development, wherein the strength is enhanced and the drawbacks of the conventional SAR addressed.

scholarly journals Synthesis and Characterization of Silver–Strontium (Ag-Sr)-Doped Mesoporous Bioactive Glass Nanoparticles

Gels ◽  
2021 ◽  
Vol 7 (2) ◽  
pp. 34
Author(s):  
Shaher Bano ◽  
Memoona Akhtar ◽  
Muhammad Yasir ◽  
Muhammad Salman Maqbool ◽  
Akbar Niaz ◽  
...  
Keyword(s):  
Bioactive Glass ◽  
Composite Coatings ◽  
Antibacterial Properties ◽  
Bone Diseases ◽  
Osteogenic Potential ◽  
Diffusion Method ◽  
Charge Composition ◽  
In Vitro Bioactivity ◽  
Mesoporous Bioactive Glass

Biomedical implants are the need of this era due to the increase in number of accidents and follow-up surgeries. Different types of bone diseases such as osteoarthritis, osteomalacia, bone cancer, etc., are increasing globally. Mesoporous bioactive glass nanoparticles (MBGNs) are used in biomedical devices due to their osteointegration and bioactive properties. In this study, silver (Ag)- and strontium (Sr)-doped mesoporous bioactive glass nanoparticles (Ag-Sr MBGNs) were prepared by a modified Stöber process. In this method, Ag+ and Sr2+ were co-substituted in pure MBGNs to harvest the antibacterial properties of Ag ions, as well as pro-osteogenic potential of Sr2 ions. The effect of the two-ion concentration on morphology, surface charge, composition, antibacterial ability, and in-vitro bioactivity was studied. Scanning electron microscopy (SEM), X-Ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR) confirmed the doping of Sr and Ag in MBGNs. SEM and EDX analysis confirmed the spherical morphology and typical composition of MBGNs, respectively. The Ag-Sr MBGNs showed a strong antibacterial effect against Staphylococcus carnosus and Escherichia coli bacteria determined via turbidity and disc diffusion method. Moreover, the synthesized Ag-Sr MBGNs develop apatite-like crystals upon immersion in simulated body fluid (SBF), which suggested that the addition of Sr improved in vitro bioactivity. The Ag-Sr MBGNs synthesized in this study can be used for the preparation of scaffolds or as a filler material in the composite coatings for bone tissue engineering.

Sign in / Sign up

Export Citation Format

Share Document