Osteoinductive Fibrous Scaffolds of Biopolymer/Mesoporous Bioactive Glass Nanocarriers with Excellent Bioactivity and Long-Term Delivery of Osteogenic Drug

2015 ◽  
Vol 7 (2) ◽  
pp. 1140-1152 ◽  
Author(s):  
Ahmed El-Fiqi ◽  
Joong-Hyun Kim ◽  
Hae-Won Kim
Keyword(s):  
Bioactive Glass ◽  
Fibrous Scaffolds ◽  
Term Delivery ◽  
Mesoporous Bioactive Glass

The Primary Investigation on Biological Effect of Mesoporous Bioactive Glass In Vivo

2013 ◽  
Vol 750-752 ◽  
pp. 1651-1655
Author(s):  
Bai Yan Sui ◽  
Cheng Tie Wu ◽  
Jiao Sun
Keyword(s):  
Bioactive Glass ◽  
Biological Effect ◽  
Degradation Products ◽  
Long Term Effect ◽  
Liver And Kidney ◽  
Mesoporous Bioactive Glass

Mesoporous bioactive glass (MBG) has superior bioactivity and degradation than non-mesoporous bioactive glass (BG) in vitro. But the biological effect of MBG in vivo is still unknown. In this study, MBG powders with 20μm were implanted into the femoral condyles in SD rats. BG powders with 20μm were used as a control. The local degradation and osteogenesis were observed at 1 week and 4 weeks after implantation, and the systemic toxicity of the degradation products were also evaluated simultaneously. The results revealed MBG powders had the faster rate of degradation and better osteogenesis effect than BG powders at 4 weeks, although the most of material still remained in situ. Histopathological analyses indicated the degradation products did not have any damage to major organs such as liver and kidney. In conclusion, this preliminary study demonstrated that MBG powders have more excellent biological effect at 4 weeks than that of BG in vivo. However the long-term effect needs to be confirmed.

scholarly journals Long-term controlled release of 125I-tagged BMP-2 by mesoporous bioactive glass with ordered nanopores

2013 ◽  
Vol 6 (6) ◽  
pp. 1443-1448 ◽  
Author(s):  
QUAN ZHANG ◽  
YE ZHANG ◽  
WENJUN CHEN ◽  
BINGWEN ZHANG ◽  
SHILONG WANG
Keyword(s):  
Controlled Release ◽  
Bioactive Glass ◽  
Mesoporous Bioactive Glass

scholarly journals Icariin controlled release on a silk fibroin/mesoporous bioactive glass nanoparticles scaffold for promoting stem cell osteogenic differentiation

RSC Advances ◽  
2020 ◽  
Vol 10 (20) ◽  
pp. 12105-12112 ◽  
Author(s):  
Xiaofeng Shen ◽  
Pengfei Yu ◽  
Hua Chen ◽  
Jiangping Wang ◽  
Binjie Lu ◽  
...  
Keyword(s):  
Stem Cell ◽  
Controlled Release ◽  
Sustained Release ◽  
Bioactive Glass ◽  
Osteogenic Differentiation ◽  
Silk Fibroin ◽  
Mesoporous Bioactive Glass

Long-term promotion of osteogenic differentiation through silk fibroin/mesoporous bioactive glass-loaded sustained release of icariin.

scholarly journals Anti-Microbial and Remineralizing Properties of Self-Adhesive Orthodontic Resin Containing Mesoporous Bioactive Glass

Materials ◽  
2021 ◽  
Vol 14 (13) ◽  
pp. 3550
Author(s):  
Aerin Choi ◽  
Kyung-Hyeon Yoo ◽  
Seog-Young Yoon ◽  
Bong-Soo Park ◽  
In-Ryoung Kim ◽  
...  
Keyword(s):  
Bond Strength ◽  
Physical Properties ◽  
Bioactive Glass ◽  
Shear Bond Strength ◽  
Antibacterial Effect ◽  
Gram Positive ◽  
Gram Negative ◽  
Gram Positive Bacteria ◽  
Significant Difference ◽  
Mesoporous Bioactive Glass

Self-adhesive resins (SARs) contain adhesives, which simplify the procedures of resin application, and primers, which provide sufficient bonding ability. In this study, mesoporous bioactive glass nanoparticles (MBN) were added to a SAR to easily improve the physical properties and remineralization ability. The experimental resins comprised 1%, 3%, and 5% MBN mixed in Ortho Connect Flow (GC Corp, Tokyo, Japan). As the MBN content in the SAR increased, the microhardness increased, and a statistically significant difference was observed between the cases of 1% and 5% MBN addition. Shear bond strength increased for 1% and 3% MBN samples and decreased for 5% MBN. The addition of MBN indicated a statistically significant antibacterial effect on both gram-negative and gram-positive bacteria. The anti-demineralization experiment showed that the remineralization length increased with the MBN content of the sample. Through the above results, we found that SAR containing MBN has antibacterial and remineralization effects. Thus, by adding MBN to the SAR, we investigated the possibility of orthodontic resin development, wherein the strength is enhanced and the drawbacks of the conventional SAR addressed.

Ions release behavior of vanadium-doped mesoporous bioactive glass particles and effect on BMSCs osteogenic differentiation via FAK/MAPK signaling pathway

2021 ◽  
Author(s):  
Jiangfeng Li ◽  
Junying Li ◽  
Yuhao Wei ◽  
Na Xu ◽  
Jingtao Li ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bioactive Glass ◽  
Osteogenic Differentiation ◽  
Bone Growth ◽  
Mapk Signaling ◽  
Release Behavior ◽  
Pentavalent Vanadium ◽  
Important Trace Element ◽  
Vanadium Ions ◽  
Mesoporous Bioactive Glass

Vanadium is an important trace element in bone to involve in bone metabolism, bone formation, and bone growth, but roles of various vanadium ions, especially pentavalent vanadium, in bone tissue...

scholarly journals Synthesis and Characterization of Silver–Strontium (Ag-Sr)-Doped Mesoporous Bioactive Glass Nanoparticles

Gels ◽  
2021 ◽  
Vol 7 (2) ◽  
pp. 34
Author(s):  
Shaher Bano ◽  
Memoona Akhtar ◽  
Muhammad Yasir ◽  
Muhammad Salman Maqbool ◽  
Akbar Niaz ◽  
...  
Keyword(s):  
Bioactive Glass ◽  
Composite Coatings ◽  
Antibacterial Properties ◽  
Bone Diseases ◽  
Osteogenic Potential ◽  
Diffusion Method ◽  
Charge Composition ◽  
In Vitro Bioactivity ◽  
Mesoporous Bioactive Glass

Biomedical implants are the need of this era due to the increase in number of accidents and follow-up surgeries. Different types of bone diseases such as osteoarthritis, osteomalacia, bone cancer, etc., are increasing globally. Mesoporous bioactive glass nanoparticles (MBGNs) are used in biomedical devices due to their osteointegration and bioactive properties. In this study, silver (Ag)- and strontium (Sr)-doped mesoporous bioactive glass nanoparticles (Ag-Sr MBGNs) were prepared by a modified Stöber process. In this method, Ag+ and Sr2+ were co-substituted in pure MBGNs to harvest the antibacterial properties of Ag ions, as well as pro-osteogenic potential of Sr2 ions. The effect of the two-ion concentration on morphology, surface charge, composition, antibacterial ability, and in-vitro bioactivity was studied. Scanning electron microscopy (SEM), X-Ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR) confirmed the doping of Sr and Ag in MBGNs. SEM and EDX analysis confirmed the spherical morphology and typical composition of MBGNs, respectively. The Ag-Sr MBGNs showed a strong antibacterial effect against Staphylococcus carnosus and Escherichia coli bacteria determined via turbidity and disc diffusion method. Moreover, the synthesized Ag-Sr MBGNs develop apatite-like crystals upon immersion in simulated body fluid (SBF), which suggested that the addition of Sr improved in vitro bioactivity. The Ag-Sr MBGNs synthesized in this study can be used for the preparation of scaffolds or as a filler material in the composite coatings for bone tissue engineering.

scholarly journals How long is long-term? Delivery of anti-HIV antibodies using AAV vector

2019 ◽  
Vol 5 ◽  
pp. 49
Author(s):  
J. Martinez-Navio ◽  
R. Desrosiers ◽  
S. Fuchs ◽  
D. Mendes ◽  
E. Rakasz ◽  
...  
Keyword(s):  
Aav Vector ◽  
Term Delivery ◽  
Hiv Antibodies ◽  
Anti Hiv
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