Tumor extracellular pH-sensitive polymeric nanocarrier-grafted platinum(iv) prodrugs for improved intracellular delivery and cytosolic reductive-triggered release

2020 ◽  
Vol 11 (12) ◽  
pp. 2212-2221 ◽  
Author(s):  
Sheng-Qi Chen ◽  
Gang Song ◽  
Chen He ◽  
Mei Hou ◽  
Wei-Dong He ◽  
...  
Keyword(s):  
Drug Release ◽  
Tumor Cells ◽  
Intracellular Delivery ◽  
Ph Sensitive ◽  
Extracellular Ph ◽  
Triggered Release ◽  
Triggered Drug Release ◽  
Release Strategy ◽  
Polymeric Nanocarrier

Extracellular pH-sensitive Pt(iv)-based nanodrugs enable preferential toxicity to tumor cells via a selectively endocytosed and triggered drug release strategy.

scholarly journals Hyperthermia and Temperature-Sensitive Nanomaterials for Spatiotemporal Drug Delivery to Solid Tumors

Pharmaceutics ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 1007
Author(s):  
Mohamadreza Amin ◽  
Wenqiu Huang ◽  
Ann L. B. Seynhaeve ◽  
Timo L. M. ten Hagen
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Cellular Level ◽  
Advanced Technology ◽  
Temperature Sensitive ◽  
Triggered Release ◽  
Adjuvant Effect ◽  
Triggered Drug Release ◽  
High Level ◽  
External Stimuli

Nanotechnology has great capability in formulation, reduction of side effects, and enhancing pharmacokinetics of chemotherapeutics by designing stable or long circulating nano-carriers. However, effective drug delivery at the cellular level by means of such carriers is still unsatisfactory. One promising approach is using spatiotemporal drug release by means of nanoparticles with the capacity for content release triggered by internal or external stimuli. Among different stimuli, interests for application of external heat, hyperthermia, is growing. Advanced technology, ease of application and most importantly high level of control over applied heat, and as a result triggered release, and the adjuvant effect of hyperthermia in enhancing therapeutic response of chemotherapeutics, i.e., thermochemotherapy, make hyperthermia a great stimulus for triggered drug release. Therefore, a variety of temperature sensitive nano-carriers, lipid or/and polymeric based, have been fabricated and studied. Importantly, in order to achieve an efficient therapeutic outcome, and taking the advantages of thermochemotherapy into consideration, release characteristics from nano-carriers should fit with applicable clinical thermal setting. Here we introduce and discuss the application of the three most studied temperature sensitive nanoparticles with emphasis on release behavior and its importance regarding applicability and therapeutic potentials.

Targetability and intracellular delivery of anti-BCG antibody-modified, pH-sensitive fusogenic immunoliposomes to tumor cells

2002 ◽  
Vol 237 (1-2) ◽  
pp. 129-137 ◽  
Author(s):  
Toshiro Mizoue ◽  
Toshiya Horibe ◽  
Kazuo Maruyama ◽  
Tomoko Takizawa ◽  
Motoharu Iwatsuru ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Intracellular Delivery ◽  
Ph Sensitive

Near-infrared laser-triggered drug release in tellurium nanosystem for simultaneous chemo-photothermal cancer therapy

2021 ◽  
Author(s):  
Linqi Duan ◽  
Ting Liu ◽  
Tianfeng Chen
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Tumor Cells ◽  
Clinical Application ◽  
Near Infrared ◽  
Infrared Laser ◽  
Normal Cells ◽  
Triggered Drug Release

Tumor cells can be selectively killed by the different tolerance of normal cells and tumor cells to temperature. However, the limited clinical application of PTT is mainly due to various...

scholarly journals pH-Sensitive N-doped carbon dots–heparin and doxorubicin drug delivery system: preparation and anticancer research

RSC Advances ◽  
2017 ◽  
Vol 7 (15) ◽  
pp. 9347-9356 ◽  
Author(s):  
Ming Zhang ◽  
Ping Yuan ◽  
Ninglin Zhou ◽  
Yutian Su ◽  
Maoni Shao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Carbon Dots ◽  
Drug Carrier ◽  
Ph Sensitive ◽  
Triggered Drug Release ◽  
Model Drug ◽  
Doped Carbon Dots

In this study, doxorubicin (DOX) hydrochloride as a model drug, N-doped carbon dots as a drug carrier, and heparin as an auxiliary medicine were selected to design and prepare a multi-functional drug delivery system with pH-triggered drug release.

A dextran–platinum(iv) conjugate as a reduction-responsive carrier for triggered drug release

2015 ◽  
Vol 3 (41) ◽  
pp. 8203-8211 ◽  
Author(s):  
Shasha He ◽  
Yuwei Cong ◽  
Dongfang Zhou ◽  
Jizhen Li ◽  
Zhigang Xie ◽  
...  
Keyword(s):  
Drug Release ◽  
Side Chains ◽  
Triggered Release ◽  
Triggered Drug Release

An amphiphilic dextran–Pt(iv) conjugate was constructed by conjugation of a hydrophobic Pt(iv) prodrug to the side chains of hydrophilic dextran. The conjugate could self-assemble into stable nanoparticle as a reduction-responsive carrier for DOX encapsulation and triggered release.

Acid-triggered drug release from micelles based on amphiphilic oligo(ethylene glycol)–doxorubicin alternative copolymers

2014 ◽  
Vol 2 (43) ◽  
pp. 7612-7619 ◽  
Author(s):  
Ying Wang ◽  
Qiaojie Luo ◽  
Rui Sun ◽  
Guangyu Zha ◽  
Xiaodong Li ◽  
...  
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Ethylene Glycol ◽  
Ph Sensitive ◽  
Triggered Drug Release

We prepared pH-sensitive amphiphilic oligo(ethylene glycol)–doxorubicin alternative conjugates for the controlled release of doxorubicin.

Thermo, pH and reduction responsive coaggregates comprising AB2C2 star terpolymers for multi-triggered release of doxorubicin

2014 ◽  
Vol 5 (10) ◽  
pp. 3335-3345 ◽  
Author(s):  
Ke Miao ◽  
Huanhuan Liu ◽  
Youliang Zhao
Keyword(s):  
Drug Release ◽  
Mixed Micelles ◽  
Triggered Release ◽  
Triggered Drug Release

Novel disulfide-linked PEG(PCL)2(PNIPAM)2 and PEG(PCL)2(PAA)2 star terpolymers were synthesized and coassembled into mixed micelles or vesicles for multi-triggered drug release.

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