A dextran–platinum(iv) conjugate as a reduction-responsive carrier for triggered drug release

2015 ◽  
Vol 3 (41) ◽  
pp. 8203-8211 ◽  
Author(s):  
Shasha He ◽  
Yuwei Cong ◽  
Dongfang Zhou ◽  
Jizhen Li ◽  
Zhigang Xie ◽  
...  
Keyword(s):  
Drug Release ◽  
Side Chains ◽  
Triggered Release ◽  
Triggered Drug Release

An amphiphilic dextran–Pt(iv) conjugate was constructed by conjugation of a hydrophobic Pt(iv) prodrug to the side chains of hydrophilic dextran. The conjugate could self-assemble into stable nanoparticle as a reduction-responsive carrier for DOX encapsulation and triggered release.

scholarly journals Hyperthermia and Temperature-Sensitive Nanomaterials for Spatiotemporal Drug Delivery to Solid Tumors

Pharmaceutics ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 1007
Author(s):  
Mohamadreza Amin ◽  
Wenqiu Huang ◽  
Ann L. B. Seynhaeve ◽  
Timo L. M. ten Hagen
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Cellular Level ◽  
Advanced Technology ◽  
Temperature Sensitive ◽  
Triggered Release ◽  
Adjuvant Effect ◽  
Triggered Drug Release ◽  
High Level ◽  
External Stimuli

Nanotechnology has great capability in formulation, reduction of side effects, and enhancing pharmacokinetics of chemotherapeutics by designing stable or long circulating nano-carriers. However, effective drug delivery at the cellular level by means of such carriers is still unsatisfactory. One promising approach is using spatiotemporal drug release by means of nanoparticles with the capacity for content release triggered by internal or external stimuli. Among different stimuli, interests for application of external heat, hyperthermia, is growing. Advanced technology, ease of application and most importantly high level of control over applied heat, and as a result triggered release, and the adjuvant effect of hyperthermia in enhancing therapeutic response of chemotherapeutics, i.e., thermochemotherapy, make hyperthermia a great stimulus for triggered drug release. Therefore, a variety of temperature sensitive nano-carriers, lipid or/and polymeric based, have been fabricated and studied. Importantly, in order to achieve an efficient therapeutic outcome, and taking the advantages of thermochemotherapy into consideration, release characteristics from nano-carriers should fit with applicable clinical thermal setting. Here we introduce and discuss the application of the three most studied temperature sensitive nanoparticles with emphasis on release behavior and its importance regarding applicability and therapeutic potentials.

Tumor extracellular pH-sensitive polymeric nanocarrier-grafted platinum(iv) prodrugs for improved intracellular delivery and cytosolic reductive-triggered release

2020 ◽  
Vol 11 (12) ◽  
pp. 2212-2221 ◽  
Author(s):  
Sheng-Qi Chen ◽  
Gang Song ◽  
Chen He ◽  
Mei Hou ◽  
Wei-Dong He ◽  
...  
Keyword(s):  
Drug Release ◽  
Tumor Cells ◽  
Intracellular Delivery ◽  
Ph Sensitive ◽  
Extracellular Ph ◽  
Triggered Release ◽  
Triggered Drug Release ◽  
Release Strategy ◽  
Polymeric Nanocarrier

Extracellular pH-sensitive Pt(iv)-based nanodrugs enable preferential toxicity to tumor cells via a selectively endocytosed and triggered drug release strategy.

Thermo, pH and reduction responsive coaggregates comprising AB2C2 star terpolymers for multi-triggered release of doxorubicin

2014 ◽  
Vol 5 (10) ◽  
pp. 3335-3345 ◽  
Author(s):  
Ke Miao ◽  
Huanhuan Liu ◽  
Youliang Zhao
Keyword(s):  
Drug Release ◽  
Mixed Micelles ◽  
Triggered Release ◽  
Triggered Drug Release

Novel disulfide-linked PEG(PCL)2(PNIPAM)2 and PEG(PCL)2(PAA)2 star terpolymers were synthesized and coassembled into mixed micelles or vesicles for multi-triggered drug release.

Multi-functional liposomes showing radiofrequency-triggered release and magnetic resonance imaging for tumor multi-mechanism therapy

Nanoscale ◽  
2015 ◽  
Vol 7 (12) ◽  
pp. 5411-5426 ◽  
Author(s):  
Bin Du ◽  
Shuping Han ◽  
Hongyan Li ◽  
Feifei Zhao ◽  
Xiangjie Su ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Drug Release ◽  
Resonance Imaging ◽  
Triggered Release ◽  
Triggered Drug Release

Schematic illustration of design of functional liposomes showing radiofrequency-triggered drug release (A) and RF targeted thermo-chemotherapy using the nanocomposite (B).

Facile synthesis of organosilica-capped mesoporous silica nanocarriers with selective redox-triggered drug release properties for safe tumor chemotherapy

2019 ◽  
Vol 7 (5) ◽  
pp. 1825-1832 ◽  
Author(s):  
Luying Shen ◽  
Shan Pan ◽  
Dechao Niu ◽  
Jianping He ◽  
Xiaobo Jia ◽  
...  
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Facile Synthesis ◽  
Triggered Drug Release ◽  
Facile Route

We develop a facile route to synthesize organosilica-capped mesoporous silica nanocarriers for efficient and safe redox-triggered tumor chemotherapy.

scholarly journals pH-triggered degradation and release of doxorubicin from zeolitic imidazolate framework-8 (ZIF8) decorated with polyacrylic acid

RSC Advances ◽  
2021 ◽  
Vol 11 (16) ◽  
pp. 9222-9234
Author(s):  
Vy Anh Tran ◽  
Sang-Wha Lee
Keyword(s):  
Drug Release ◽  
Polyacrylic Acid ◽  
Acidic Ph ◽  
Zeolitic Imidazolate Framework ◽  
Triggered Drug Release

The ZIF8–Dox@PAA nanocarrier demonstrated pH-triggered drug release through the detachment of the PAA layer along with the destruction of ZIF8 framework in acidic pH environment.

PEG–PEI-modified gated N-doped mesoporous carbon nanospheres for pH/NIR light-triggered drug release and cancer phototherapy

2021 ◽  
Author(s):  
Snigdharani Panda ◽  
Chandra Sekhar Bhol ◽  
Sujit Kumar Bhutia ◽  
Sasmita Mohapatra
Keyword(s):  
Drug Release ◽  
Mesoporous Carbon ◽  
Laser Excitation ◽  
Outer Shell ◽  
Carbon Nanospheres ◽  
Nir Light ◽  
Triggered Drug Release ◽  
Hybrid Nanoparticle

A hybrid nanoparticle consisting of N-doped mesoporous carbon nanospheres as core and thermosensitive PEG–PEI as outer shell shows multiple therapeutic actions such as PTT, PDT and NIR sensitive drug release under single 980 nm laser excitation.

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