scholarly journals Hyperthermia and Temperature-Sensitive Nanomaterials for Spatiotemporal Drug Delivery to Solid Tumors

Pharmaceutics ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 1007
Author(s):  
Mohamadreza Amin ◽  
Wenqiu Huang ◽  
Ann L. B. Seynhaeve ◽  
Timo L. M. ten Hagen
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Cellular Level ◽  
Advanced Technology ◽  
Temperature Sensitive ◽  
Triggered Release ◽  
Adjuvant Effect ◽  
Triggered Drug Release ◽  
High Level ◽  
External Stimuli

Nanotechnology has great capability in formulation, reduction of side effects, and enhancing pharmacokinetics of chemotherapeutics by designing stable or long circulating nano-carriers. However, effective drug delivery at the cellular level by means of such carriers is still unsatisfactory. One promising approach is using spatiotemporal drug release by means of nanoparticles with the capacity for content release triggered by internal or external stimuli. Among different stimuli, interests for application of external heat, hyperthermia, is growing. Advanced technology, ease of application and most importantly high level of control over applied heat, and as a result triggered release, and the adjuvant effect of hyperthermia in enhancing therapeutic response of chemotherapeutics, i.e., thermochemotherapy, make hyperthermia a great stimulus for triggered drug release. Therefore, a variety of temperature sensitive nano-carriers, lipid or/and polymeric based, have been fabricated and studied. Importantly, in order to achieve an efficient therapeutic outcome, and taking the advantages of thermochemotherapy into consideration, release characteristics from nano-carriers should fit with applicable clinical thermal setting. Here we introduce and discuss the application of the three most studied temperature sensitive nanoparticles with emphasis on release behavior and its importance regarding applicability and therapeutic potentials.

Drug Release Behaviors of a pH/Temperature Sensitive Hydrogel Bead with Core-Shelled Structure

2010 ◽  
Vol 148-149 ◽  
pp. 1427-1430 ◽  
Author(s):  
Kui Lin Deng ◽  
Li Rong Dong ◽  
Yu E Shi ◽  
Yu Bo Gou ◽  
Qian Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Phosphate Buffer Solution ◽  
Temperature Sensitive ◽  
Buffer Solution ◽  
Hydrogel Bead ◽  
The Core ◽  
Drug Delivery Carrier ◽  
Temperature Sensitive Hydrogel ◽  
Biomedical Fields

As a drug delivery carrier, a novel pH/temperature sensitive bead (pTSB) with core-shelled structure from poly(N-acryloylglycine) (PAG), copoly(N-acryloylglycine methyl este and N-acryloylglycine ethyl ester) was prepared by two steps. In pH=7.4 phosphate buffer solution (PBS), the cumulative release amount of indomethacin loaded in the pTSB was about 60.1 % within 500 mins, but this value only reached to 22.3 % in pH=2.1 PBS. The release behaviors of indomethacin from pTSB also exhibited a remarkable dependence on PAG content in the core. Additionally, the release rate of indomethacin was much faster at 18 oC than that at 37 oC due to the temperature sensitivity of poly(N-acryloylglycinates). The experimental results indicate that pTSB seems to have a potential application in the drug release system controlled via pH or temperature in the biomedical fields.

scholarly journals pH-triggered drug release from biodegradable microwells for oral drug delivery

2015 ◽  
Vol 17 (3) ◽  
Author(s):  
Line Hagner Nielsen ◽  
Johan Nagstrup ◽  
Sarah Gordon ◽  
Stephan Sylvest Keller ◽  
Jesper Østergaard ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Oral Drug Delivery ◽  
Oral Drug ◽  
Triggered Drug Release

A Smart Drug Delivery System Based on Thermo-Responsive Polymer Gated Au NRs@SiO2 Nano-Platform

2021 ◽  
Vol 16 (7) ◽  
pp. 1029-1036
Author(s):  
Hongzhu Wang ◽  
Mengxun Chen ◽  
Liping Song ◽  
Youju Huang
Keyword(s):  
Drug Delivery ◽  
Block Copolymer ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Photothermal Therapy ◽  
Drug Loading ◽  
Temperature Sensitive

A key challenge for nanoparticles-based drug delivery system is to achieve manageable drug release in tumour cell. In this study, a versatile system combining photothermal therapy and controllable drug release for tumour cells using temperature-sensitive block copolymer coupled Au NRs@SiO2 is reported. While the Au NRs serve as hyperthermal agent and the mesoporous silica was used to improve the drug loading and decrease biotoxicity. The block copolymer acted as “gatekeeper” to regulate the release of model drug (Doxorubicin hydrochloride, DOX). Through in vivo and in vitro experiments, we achieved the truly controllable drug release and photothermal therapy with the collaborative effect of the three constituents of the nanocomposites. The reported nanocomposites pave the way to high-performance controllable drug release and photothermal therapy system.

An acoustic/thermo-responsive hybrid system for advanced doxorubicin delivery in tumor treatment

2020 ◽  
Vol 8 (8) ◽  
pp. 2202-2211 ◽  
Author(s):  
Li Zhang ◽  
Shiyu Zhang ◽  
Huajian Chen ◽  
Yu Liang ◽  
Bingxia Zhao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Hybrid System ◽  
Tumor Treatment ◽  
Triggered Drug Release ◽  
Ultrasound Assisted ◽  
Doxorubicin Delivery

Ultrasound-assisted fast extravasation and the following laser-triggered drug release of thermo-sensitive liposomes synergistically enhanced drug delivery in deep tumors.

Optimization of upconversion luminescence of Nd3+-sensitized BaGdF5-based nanostructures and their application in dual-modality imaging and drug delivery

2016 ◽  
Vol 45 (4) ◽  
pp. 1708-1716 ◽  
Author(s):  
Fei He ◽  
Chunxia Li ◽  
Xinyang Zhang ◽  
Yinyin Chen ◽  
Xiaoran Deng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Upconversion Luminescence ◽  
Dual Model ◽  
Dual Modality ◽  
Triggered Drug Release ◽  
Dual Modality Imaging

Nd3+-sensitized BaGdF5:20%Yb3+/2%Er3+@BaGdF5:10%Yb3+@BaNdF5@BaGdF5 nanoparticles for dual-model imaging and pH-triggered drug release.

Biotin-guided anticancer drug delivery with acidity-triggered drug release

2015 ◽  
Vol 51 (45) ◽  
pp. 9343-9345 ◽  
Author(s):  
Soyeon Park ◽  
Eunjin Kim ◽  
Won Young Kim ◽  
Chulhun Kang ◽  
Jong Seung Kim
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Anticancer Drug ◽  
Delivery System ◽  
Anticancer Drug Delivery ◽  
Triggered Drug Release

A novel biotin-guided anticancer drug delivery system, prodrug 9, consisting of biotin, nitrobenzene, and doxorubicin, with acid-triggered drug releasing capability was synthesized.

A pH-responsive AIE nanoprobe as a drug delivery system for bioimaging and cancer therapy

2015 ◽  
Vol 3 (37) ◽  
pp. 7401-7407 ◽  
Author(s):  
Haibo Wang ◽  
Gongyan Liu ◽  
Shihua Dong ◽  
Junjie Xiong ◽  
Zongliang Du ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Cellular Imaging ◽  
Ph Responsive ◽  
Triggered Drug Release

A multifunctional drug delivery system with AIE character was designed and constructed for simultaneous cellular imaging and pH-triggered drug release.

A multifunctional PEG–PLL drug conjugate forming redox-responsive nanoparticles for intracellular drug delivery

2015 ◽  
Vol 3 (38) ◽  
pp. 7594-7603 ◽  
Author(s):  
Zhuxian Zhou ◽  
Jianbin Tang ◽  
Qihang Sun ◽  
William J. Murdoch ◽  
Youqing Shen
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Tumor Targeting ◽  
High Stability ◽  
Cancer Targeting ◽  
Drug Conjugate ◽  
Intracellular Drug Delivery ◽  
Redox Responsive ◽  
Triggered Drug Release

Tumor-targeting camptothecin (CPT)-conjugated nanoparticles with high stability and GSH-triggered drug release were developed for cancer targeting drug delivery.

scholarly journals UVA-Triggered Drug Release and Photo-Protection of Skin

2021 ◽  
Vol 9 ◽  
Author(s):  
Vega Widya Karisma ◽  
Wei Wu ◽  
Mingxing Lei ◽  
Huawen Liu ◽  
Muhammad Farrukh Nisar ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery Systems ◽  
Controlled Drug Release ◽  
Clinical Use ◽  
Ultraviolet A ◽  
Light Stimuli ◽  
Triggered Drug Release ◽  
Photo Cleavage ◽  
Uva Radiation

Light has attracted special attention as a stimulus for triggered drug delivery systems (DDS) due to its intrinsic features of being spatially and temporally tunable. Ultraviolet A (UVA) radiation has recently been used as a source of external light stimuli to control the release of drugs using a “switch on- switch off” procedure. This review discusses the promising potential of UVA radiation as the light source of choice for photo-controlled drug release from a range of photo-responsive and photolabile nanostructures via photo-isomerization, photo-cleavage, photo-crosslinking, and photo-induced rearrangement. In addition to its clinical use, we will also provide here an overview of the recent UVA-responsive drug release approaches that are developed for phototherapy and skin photoprotection.

Tumor extracellular pH-sensitive polymeric nanocarrier-grafted platinum(iv) prodrugs for improved intracellular delivery and cytosolic reductive-triggered release

2020 ◽  
Vol 11 (12) ◽  
pp. 2212-2221 ◽  
Author(s):  
Sheng-Qi Chen ◽  
Gang Song ◽  
Chen He ◽  
Mei Hou ◽  
Wei-Dong He ◽  
...  
Keyword(s):  
Drug Release ◽  
Tumor Cells ◽  
Intracellular Delivery ◽  
Ph Sensitive ◽  
Extracellular Ph ◽  
Triggered Release ◽  
Triggered Drug Release ◽  
Release Strategy ◽  
Polymeric Nanocarrier

Extracellular pH-sensitive Pt(iv)-based nanodrugs enable preferential toxicity to tumor cells via a selectively endocytosed and triggered drug release strategy.

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