Core–shell protein clusters comprising haemoglobin and recombinant feline serum albumin as an artificial O2carrier for cats

2018 ◽  
Vol 6 (16) ◽  
pp. 2417-2425 ◽  
Author(s):  
Kyoko Yokomaku ◽  
Motofusa Akiyama ◽  
Yoshitsugu Morita ◽  
Kiyohito Kihira ◽  
Teruyuki Komatsu
Keyword(s):  
Blood Cell ◽  
Serum Albumin ◽  
Red Blood Cell ◽  
Core Shell ◽  
Serum Albumins ◽  
Shell Protein ◽  
Protein Clusters

Dual-protein clusters comprising haemoglobin and recombinant feline serum albumins as a red blood cell substitute for exclusive use in cats.

scholarly journals Core–shell clusters of human haemoglobin A and human serum albumin: artificial O2-carriers having various O2-affinities

2015 ◽  
Vol 3 (30) ◽  
pp. 6157-6164 ◽  
Author(s):  
Takuya Kimura ◽  
Ryuichi Shinohara ◽  
Christoph Böttcher ◽  
Teruyuki Komatsu
Keyword(s):  
Human Serum Albumin ◽  
Blood Cell ◽  
Serum Albumin ◽  
Human Serum ◽  
Red Blood Cell ◽  
Core Shell ◽  
Human Haemoglobin ◽  
Artificial O2 Carriers

Core–shell clusters composed of human haemoglobin A and human serum albumin having various O2-affinities have been synthesized as potential O2-carriers designed as red blood cell substitutes.

Genetically engineered haemoglobin wrapped covalently with human serum albumins as an artificial O2 carrier

2020 ◽  
Vol 8 (6) ◽  
pp. 1139-1145 ◽  
Author(s):  
Ryosuke Funaki ◽  
Wataru Okamoto ◽  
Chihiro Endo ◽  
Yoshitsugu Morita ◽  
Kiyohito Kihira ◽  
...  
Keyword(s):  
Blood Cell ◽  
Human Serum ◽  
Red Blood Cell ◽  
Genetically Engineered ◽  
Core Shell ◽  
Serum Albumins ◽  
Human Haemoglobin

Recombinant human haemoglobin expressed in Pichia yeast was wrapped covalently with recombinant human serum albumins, yielding a core–shell structured rHbA(X)–rHSA3 cluster as an entirely synthetic O2 carrier used for a red blood cell substitute.

Bovine serum albumin bioconjugated graphene oxide: Red blood cell adhesion and hemolysis studied by QCM-D

2015 ◽  
Vol 356 ◽  
pp. 844-851 ◽  
Author(s):  
Bing Cai ◽  
Kebang Hu ◽  
Chunming Li ◽  
Jing Jin ◽  
Yuexin Hu
Keyword(s):  
Graphene Oxide ◽  
Cell Adhesion ◽  
Bovine Serum Albumin ◽  
Blood Cell ◽  
Serum Albumin ◽  
Red Blood Cell ◽  
Bovine Serum

scholarly journals Biomimetic Nanotherapies: Red Blood Cell Based Core–Shell Structured Nanocomplexes for Atherosclerosis Management

2019 ◽  
Vol 6 (12) ◽  
pp. 1900172 ◽  
Author(s):  
Yi Wang ◽  
Kang Zhang ◽  
Xian Qin ◽  
Tianhan Li ◽  
Juhui Qiu ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Core Shell

scholarly journals Correlation of Albumin Serum Levels as Inflammation Marker with Red Blood Cell Distribution Width Value in Regular Hemodialysis Patients at H. Adam Malik General Hospital Medan

2021 ◽  
Vol 8 (7) ◽  
pp. 369-374
Author(s):  
Soraya Mourina Hutasuhut ◽  
Alwi Thamrin Nasution ◽  
M. Feldy Gazaly Nasution
Keyword(s):  
Blood Cell ◽  
Serum Albumin ◽  
General Hospital ◽  
Red Blood Cell ◽  
Serum Levels ◽  
Cell Distribution ◽  
Distribution Width ◽  
The Mean ◽  
Red Blood Cell Distribution ◽  
Regular Hemodialysis

Background: One of the modalities of renal replacement therapy in chronic kidney disease (CKD) is hemodialysis (HD). The role of inflammation in HD patients by uremic toxins and dialysis can be assessed by the marker of serum albumin. This inflammation also causes dysregulation of the hormone erythropoietin which results in increased variability or heterogeneity of red blood cell distribution width (RDW). Previous studies have revealed an association between RDW and albumin levels in regular HD patients which leads to increased patient morbidity and mortality. This study aims to determine the relationship between albumin serum levels and RDW as a marker of inflammation in regular HD patients. Method: This was a cross sectional study design, conducted in June to August 2020 at the HD unit of Haji Adam Malik General Hospital in Medan. Twenty subjects were included. Data were analyzed using Pearson correlation test and T-test to find the correlation between albumin serum levels and RDW, and other variables. Results: Of the 20 subjects taken based on consecutive sampling, the majority was male, 13 people (65%), mean age was 50.30 ± 12.57 years with the most comorbid type 2 diabetes mellitus for 14 people (70%). The mean serum albumin level was 3.2 ± 0.65 mg/dl. The mean RDW value was 15.93 ± 1.87%. This study showed that there was a significant relationship between serum albumin levels and RDW values ​​(r = - 0.687; p = 0.001). RDW values ​​were also significantly associated with hemoglobin levels (r = 0.497; p = 0.026) and creatinine (r= 0.519; p= 0.019). Conclusion: Albumin, hemoglobin, and creatinine levels were significantly associated with RDW values ​​in regular HD patients. Keywords: inflammation, albumin, regular hemodialysis, RDW.

In vitro binding of dantrolene to bovine serum albumin and rabbit red blood cell ghosts

1982 ◽  
Vol 60 (10) ◽  
pp. 1307-1311 ◽  
Author(s):  
A. R. Dehpour ◽  
M. Mahmoudian
Keyword(s):  
Bovine Serum Albumin ◽  
Blood Cell ◽  
Serum Albumin ◽  
Red Blood Cell ◽  
Binding Sites ◽  
Blood Cells ◽  
Bovine Serum ◽  
Association Constant ◽  
Dantrolene Sodium

The binding of dantrolene to rabbit red blood cell (RBC) ghosts and bovine serum albumin as models of receptor sites was studied using fluorescence techniques. Dantrolene upon binding to rabbit RBC ghosts and bovine serum albumin showed fluorescence with emission maxima at 495 and 500 nm, respectively. Dantrolene bound to rabbit RBC ghosts with an association constant of 6.06 × 104 M−1 and there were 2.4 × 106 dantrolene binding sites per ghost. The binding of dantrolene to bovine serum albumin showed an anomaly with respect to dantrolene concentration. Dantrolene at concentrations of 1.25 – 3.75 μM bound to bovine serum albumin with an association constant of 1.72 × 104 M−1 and there were 1.078 binding sites/mol bovine serum albumin. The higher affinity of dantrolene toward blood cells was confirmed by studying the distribution of dantrolene between blood cells and plasma after a single i.p. injection of dantrolene sodium (3 mg/kg) to albino rabbits. It was found that the concentration of dantrolene in rabbit blood cells was 2.76 times that of plasma.

Effect of Bovine Serum Albumin on Red Blood Cell Optical Anisotropy Probed Through the Optomechanical Response in an Optical Trap

2017 ◽  
Vol 376 (1) ◽  
pp. 1600209
Author(s):  
Parthasarathi Praveen ◽  
Selvan Rekha ◽  
Devarkonda Chetana ◽  
Shruthi S. Iyengar ◽  
Sarbari Bhattacharya ◽  
...  
Keyword(s):  
Bovine Serum Albumin ◽  
Blood Cell ◽  
Serum Albumin ◽  
Red Blood Cell ◽  
Bovine Serum ◽  
Optical Anisotropy ◽  
Optical Trap

Dual sensitive and rapid detection of glycated human serum albumin using a versatile lead/graphene nanocomposite probe as a fluorescence-electrochemical aptasensor

The Analyst ◽  
2021 ◽  
Author(s):  
Thitirat Putnin ◽  
Wassa Waiwinya ◽  
Dechnarong Pimalai ◽  
Wireeya Chawjiraphan ◽  
Nuankanya Sathirapongsasuti ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Human Serum Albumin ◽  
Blood Cell ◽  
Serum Albumin ◽  
Human Serum ◽  
Red Blood Cell ◽  
Rapid Detection ◽  
Electrochemical Aptasensor ◽  
Graphene Nanocomposite

Monitoring of glycated human serum albumin (GHSA) as a glycemic marker for screening and monitoring of diabetes mellitus is widely practiced for patients with conditions that affect red blood cell....

Human serum albumin incorporating synthetic heme: Red blood cell substitute without hypertension by nitric oxide scavenging

2003 ◽  
Vol 64A (2) ◽  
pp. 257-261 ◽  
Author(s):  
Eishun Tsuchida ◽  
Teruyuki Komatsu ◽  
Yasuko Matsukawa ◽  
Akito Nakagawa ◽  
Hiromi Sakai ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Human Serum Albumin ◽  
Blood Cell ◽  
Serum Albumin ◽  
Human Serum ◽  
Red Blood Cell

CARDIORESPIRATORY STATUS OF ERYTHROBLASTOTIC NEWBORN INFANTS: II. BLOOD VOLUME, HEMATOCRIT, AND SERUM ALBUMIN CONCENTRATION IN RELATION TO HYDROPS FETALIS

PEDIATRICS ◽  
1974 ◽  
Vol 53 (1) ◽  
pp. 13-23
Author(s):  
R. H. Phibbs ◽  
P. Johnson ◽  
W. H. Tooley ◽  
B. Bradley Johnson ◽  
D. Sudman ◽  
...  
Keyword(s):  
Blood Cell ◽  
Serum Albumin ◽  
Blood Volume ◽  
Plasma Volume ◽  
Red Blood Cell ◽  
Newborn Infants ◽  
Hydrops Fetalis ◽  
Albumin Concentration ◽  
Serum Albumin Concentration ◽  
Blood Volumes

We measured hematocrit and serum albumin concentration at birth and red blood cell and plasma volume soon after birth in prematurely born infants with erythroblastosis fetalis of varying severity and examined the realtionships between these variables and the presence and severity of hydrops fetalis. Blood volumes in most of these infants were similar to the established normals for newborn infants without erythroblastosis. There was no simple association between blood volume and the presence of hydrops. Nonhydropic and severely hydropic infants had, on the average, similar and normal blood volumes, while mildly hydropic infants had low blood volumes. Anemia correlated fairly well with severity of hydrops but almost a quarter of the infants with severe hydrops were only mildly anemic. Red blood cell volume decreased and plasma volume increased proportionally with the degree of anemia at birth. Thus, hydropic infants with severe anemia had large plasma volumes while those with milder anemia did not. On the other hand, hypoalbuminemia was common and correlated closely with severity of hydrops. We suggest that hydrops results at least in part from low plasma colloid osmotic pressure due to hypoalbuminemia.

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