Dual sensitive and rapid detection of glycated human serum albumin using a versatile lead/graphene nanocomposite probe as a fluorescence-electrochemical aptasensor

The Analyst ◽  
2021 ◽  
Author(s):  
Thitirat Putnin ◽  
Wassa Waiwinya ◽  
Dechnarong Pimalai ◽  
Wireeya Chawjiraphan ◽  
Nuankanya Sathirapongsasuti ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Human Serum Albumin ◽  
Blood Cell ◽  
Serum Albumin ◽  
Human Serum ◽  
Red Blood Cell ◽  
Rapid Detection ◽  
Electrochemical Aptasensor ◽  
Graphene Nanocomposite

Monitoring of glycated human serum albumin (GHSA) as a glycemic marker for screening and monitoring of diabetes mellitus is widely practiced for patients with conditions that affect red blood cell....

scholarly journals Core–shell clusters of human haemoglobin A and human serum albumin: artificial O2-carriers having various O2-affinities

2015 ◽  
Vol 3 (30) ◽  
pp. 6157-6164 ◽  
Author(s):  
Takuya Kimura ◽  
Ryuichi Shinohara ◽  
Christoph Böttcher ◽  
Teruyuki Komatsu
Keyword(s):  
Human Serum Albumin ◽  
Blood Cell ◽  
Serum Albumin ◽  
Human Serum ◽  
Red Blood Cell ◽  
Core Shell ◽  
Human Haemoglobin ◽  
Artificial O2 Carriers

Core–shell clusters composed of human haemoglobin A and human serum albumin having various O2-affinities have been synthesized as potential O2-carriers designed as red blood cell substitutes.

Human serum albumin incorporating synthetic heme: Red blood cell substitute without hypertension by nitric oxide scavenging

2003 ◽  
Vol 64A (2) ◽  
pp. 257-261 ◽  
Author(s):  
Eishun Tsuchida ◽  
Teruyuki Komatsu ◽  
Yasuko Matsukawa ◽  
Akito Nakagawa ◽  
Hiromi Sakai ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Human Serum Albumin ◽  
Blood Cell ◽  
Serum Albumin ◽  
Human Serum ◽  
Red Blood Cell

Increased oxidized form of human serum albumin in patients with diabetes mellitus

1992 ◽  
Vol 18 (3) ◽  
pp. 153-158 ◽  
Author(s):  
Eiji Suzuki ◽  
Keigo Yasuda ◽  
Noriyuki Takeda ◽  
Shigeki Sakata ◽  
Seiichi Era ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Patients With Diabetes

scholarly journals Enhanced nonenzymatic glucosylation of human serum albumin in diabetes mellitus.

1979 ◽  
Vol 76 (9) ◽  
pp. 4258-4261 ◽  
Author(s):  
C. E. Guthrow ◽  
M. A. Morris ◽  
J. F. Day ◽  
S. R. Thorpe ◽  
J. W. Baynes
Keyword(s):  
Diabetes Mellitus ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum

scholarly journals The THE ROLE OF ASTAXANTHIN COMPARED WITH METFORMIN IN PREVENTING GLYCATED HUMAN SERUM ALBUMIN FROM POSSIBLE UNFOLDING: A MOLECULAR DYNAMIC STUDY

2019 ◽  
pp. 276-282
Author(s):  
SYAHPUTRA WIBOWO ◽  
SRI WIDYARTI ◽  
AKHMAD SABARUDIN ◽  
DJOKO WAHONO SOEATMADJI ◽  
SUTIMAN BAMBANG SUMITRO
Keyword(s):  
Diabetes Mellitus ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Root Mean Square ◽  
Conformational Changes ◽  
Glycated Albumin ◽  
Mean Square ◽  
Discovery Studio ◽  
Significant Difference

Objectives: Albumin in diabetes mellitus undergoes conformational changes that affect the ability as an endogenous scavenger. Treatment with astaxanthin (ASX) expected to improve the function of albumin in case of diabetes mellitus. The objectives of this study are to compare the capability of ASX and metformin to prevent conformational changes on glycated albumin. Methods: Data mining is performed to obtain human serum albumin (HSA) (4K2C), glucose (79025), ASX (5281224), and metformin (4091). Data preparation used PyRx and Discovery Studio 2016 Client. PyRx is utilized for docking and analysis of receptor-ligand interactions with LigPlus and Discovery Studio 2016 Client. YASARA is used for molecular dynamics simulations with a running time of 15.000 ps. Results: A description of the glycated-HSA (gHSA) conformational changes that are bound to metformin has been successfully carried out. Changes that occur were unfolding and release of bonds in gHSA. Unfolding on gHSA includes the release of bonds between sites A and B. The root mean square deviation (RMSD) backbone value of metformin-gHSA shows a significant difference with gHSA at 8650 ps where gHSA showed 6.47 nm while the metformin-gHSA was 8.06 nm and continues to increase up to 15.72 nm at the end of the simulation. RMSD and root mean square fluctuation residues of gHSA which were interacted with ASX showed conditions close to normal HSA. In 11725 ps ASX-gHSA remained stable at 5.78 nm, whereas gHSA increased to 8.13 nm. gHSA at the end of the simulation showed a number of 9.052 nm while the normal HSA was 7.561 nm. Conclusion: This result indicated that ASX prevents gHSA from possible unfolding.

Structural and immunological characterization of Amadori-rich human serum albumin: Role in diabetes mellitus

2012 ◽  
Vol 522 (1) ◽  
pp. 17-25 ◽  
Author(s):  
Binish Arif ◽  
Jalaluddin M. Ashraf ◽  
Moinuddin ◽  
Jamal Ahmad ◽  
Zarina Arif ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Immunological Characterization

A Portable Device for Rapid Detection of Human Serum Albumin using an immunoglobulin-coating-based Magnetoelastic Biosensor

2019 ◽  
Vol 141 ◽  
pp. 111399 ◽  
Author(s):  
Shengbo Sang ◽  
Yuchao Li ◽  
Xing Guo ◽  
Bo Zhang ◽  
Xianwei Xue ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Rapid Detection ◽  
Portable Device
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