Spontaneous transfer of droplets across microfluidic laminar interfaces

Lab on a Chip ◽  
2016 ◽  
Vol 16 (22) ◽  
pp. 4326-4332 ◽  
Author(s):  
Nan-Nan Deng ◽  
Wei Wang ◽  
Xiao-Jie Ju ◽  
Rui Xie ◽  
Liang-Yin Chu
Keyword(s):  
Passive Transfer ◽  
Microfluidic System ◽  
Immiscible Fluids ◽  
Precise Control ◽  
Interfacial Energies ◽  
System P ◽  
Three Phase ◽  
Spontaneous Transfer

Passive transfer of droplets across the laminar interfaces of two immiscible fluids is successfully achieved by precise control of the interfacial energies in a three phase microfluidic system.

Real-time Red Blood Cell Counting and Osmolarity Analysis using a Photoacoustic-based Microfluidic System

Lab on a Chip ◽  
2021 ◽  
Author(s):  
Wenxiu Zhao ◽  
Haibo Yu ◽  
Yangdong Wen ◽  
Hao Luo ◽  
Boliang Jia ◽  
...  
Keyword(s):  
Blood Cell ◽  
Physical Properties ◽  
Red Blood Cell ◽  
Blood Cells ◽  
Diagnostic Procedure ◽  
Microfluidic System ◽  
Cell Counting ◽  
Blood Samples ◽  
System P ◽  
Blood Cell Counting

Counting the number of red blood cells (RBCs) in blood samples is a common clinical diagnostic procedure, but conventional methods are unable to provide the size and other physical properties...

Label-free biosensors based on in situ formed and functionalized microwires in microfluidic devices

The Analyst ◽  
2015 ◽  
Vol 140 (23) ◽  
pp. 7896-7901 ◽  
Author(s):  
Yanlong Xing ◽  
Andreas Wyss ◽  
Norbert Esser ◽  
Petra S. Dittrich
Keyword(s):  
Microfluidic Devices ◽  
Microfluidic System ◽  
Label Free ◽  
System P

Label-free biosensors based on in situ formed and functionalized TTF–Au wires were developed using an integrated microfluidic system.

scholarly journals Development of a Gas-Tight Microfluidic System for Raman Sensing of Single Pulmonary Arterial Smooth Muscle Cells Under Normoxic/Hypoxic Conditions

Sensors ◽  
2018 ◽  
Vol 18 (10) ◽  
pp. 3238 ◽  
Author(s):  
Fenja Knoepp ◽  
Joel Wahl ◽  
Anders Andersson ◽  
Johan Borg ◽  
Norbert Weissmann ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Redox State ◽  
Microfluidic System ◽  
Hypoxic Conditions ◽  
Kv Channels ◽  
System P ◽  
Pulmonary Arterial ◽  
Arterial Smooth Muscle Cells ◽  
Pulmonary Arterial Smooth Muscle ◽  
Gas Tight

Acute hypoxia changes the redox-state of pulmonary arterial smooth muscle cells (PASMCs). This might influence the activity of redox-sensitive voltage-gated K+-channels (Kv-channels) whose inhibition initiates hypoxic pulmonary vasoconstriction (HPV). However, the molecular mechanism of how hypoxia—or the subsequent change in the cellular redox-state—inhibits Kv-channels remains elusive. For this purpose, a new multifunctional gas-tight microfluidic system was developed enabling simultaneous single-cell Raman spectroscopic studies (to sense the redox-state under normoxic/hypoxic conditions) and patch-clamp experiments (to study the Kv-channel activity). The performance of the system was tested by optically recording the O2-content and taking Raman spectra on murine PASMCs under normoxic/hypoxic conditions or in the presence of H2O2. Oxygen sensing showed that hypoxic levels in the gas-tight microfluidic system were achieved faster, more stable and significantly lower compared to a conventional open system (1.6 ± 0.2%, respectively 6.7 ± 0.7%, n = 6, p < 0.001). Raman spectra revealed that the redistribution of biomarkers (cytochromes, FeS, myoglobin and NADH) under hypoxic/normoxic conditions were improved in the gas-tight microfluidic system (p-values from 0.00% to 16.30%) compared to the open system (p-value from 0.01% to 98.42%). In conclusion, the new redox sensor holds promise for future experiments that may elucidate the role of Kv-channels during HPV.

A superamphiphobic surface with a hydrogen peroxide-triggered switch to antithetic fluid repellence in a liquid–liquid–air three-phase fluid system

2020 ◽  
Vol 56 (31) ◽  
pp. 4312-4315
Author(s):  
Yihan Sun ◽  
Jinxia Huang ◽  
Zhiguang Guo
Keyword(s):  
Hydrogen Peroxide ◽  
The Other ◽  
Fluid System ◽  
System P ◽  
Arbitrary Phase ◽  
Three Phase ◽  
Air System ◽  
Two Phases ◽  
Phase Fluid

Fluid repellence in one arbitrary phase for repelling the other two phases in a generalized liquid–liquid–air system was achieved on a hydrogen peroxide-treated surface.

scholarly journals In-flow measurement of cell–cell adhesion using oscillatory inertial microfluidics

Lab on a Chip ◽  
2020 ◽  
Vol 20 (9) ◽  
pp. 1612-1620 ◽  
Author(s):  
Baris R. Mutlu ◽  
Taronish Dubash ◽  
Claudius Dietsche ◽  
Avanish Mishra ◽  
Arzu Ozbey ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Adhesion Strength ◽  
Flow Measurement ◽  
Microfluidic System ◽  
Suspended Cell ◽  
Inertial Microfluidics ◽  
Cell Clusters ◽  
System P ◽  
Freely Suspended ◽  
Cell Cell

Cell–cell adhesion strength of freely suspended cell clusters can be measured using an oscillatory inertial microfluidic system.

scholarly journals Moving mechanisms of the three-phase contact line in a water–decane–silica system

RSC Advances ◽  
2019 ◽  
Vol 9 (6) ◽  
pp. 3092-3101 ◽  
Author(s):  
Wenxiu Zheng ◽  
Chengzhen Sun ◽  
Boyao Wen ◽  
Bofeng Bai
Keyword(s):  
Liquid Phase ◽  
Contact Line ◽  
Phase Contact ◽  
Chain Molecules ◽  
System P ◽  
Three Phase

Wettability-related moving mechanisms of the three-phase contact line with one liquid phase composed of chain molecules are revealed.

Continuous synthesis of hedgehog-like Ag–ZnO nanoparticles in a two-stage microfluidic system

RSC Advances ◽  
2016 ◽  
Vol 6 (51) ◽  
pp. 45503-45511 ◽  
Author(s):  
Sha Tao ◽  
Mei Yang ◽  
Huihui Chen ◽  
Mingyue Ren ◽  
Guangwen Chen
Keyword(s):  
Photocatalytic Activity ◽  
Methyl Orange ◽  
Zno Nanoparticles ◽  
Microfluidic System ◽  
Two Stage ◽  
Continuous Synthesis ◽  
System P ◽  
Degradation Of Methyl Orange

Hedgehog-like Ag–ZnO nanoparticles were successfully prepared in a continuous microfluidic system and showed a superior photocatalytic activity in the degradation of methyl orange.

Rapid isolation and diagnosis of live bacteria from human joint fluids by using an integrated microfluidic system

Lab on a Chip ◽  
2014 ◽  
Vol 14 (17) ◽  
pp. 3376-3384 ◽  
Author(s):  
Wen-Hsin Chang ◽  
Chih-Hung Wang ◽  
Sung-Yi Yang ◽  
Yi-Cheng Lin ◽  
Jiunn-Jong Wu ◽  
...  
Keyword(s):  
Periprosthetic Joint Infection ◽  
Joint Infection ◽  
Microfluidic System ◽  
Rapid Isolation ◽  
System P ◽  
Live Bacteria ◽  
Human Joint

An integrated microfluidic system capable of detecting live bacteria from clinical periprosthetic joint infection (PJI) samples within 55 minutes was developed in this study.

scholarly journals Microfluidic conformal coating of non-spherical magnetic particles

2021 ◽  
Author(s):  
Byeong-Ui Moon ◽  
Navid Hakimi ◽  
Dae Kun Hwang ◽  
Scott S. H. Tsai
Keyword(s):  
Thin Film ◽  
Interfacial Tension ◽  
Magnetic Particles ◽  
Magnetic Field Gradient ◽  
Interfacial Area ◽  
Aqueous Fluid ◽  
Microfluidic System ◽  
Immiscible Fluids ◽  
Spherical Particles ◽  
Conformal Coating

We present the conformal coating of non-spherical magnetic particles in a co-laminar flow microfluidic system. Whereas in the previous reports spherical particles had been coated with thin films that formed spheres around the particles; in this article, we show the coating of non-spherical particles with coating layers that are approximately uniform in thickness. The novelty of our work is that while liquid-liquid interfacial tension tends to minimize the surface area of interfaces—for example, to form spherical droplets that encapsulate spherical particles—in our experiments, the thin film that coats non-spherical particles has a non-minimal interfacial area. We first make bullet-shaped magnetic microparticles using a stop-flow lithography method that was previously demonstrated. We then suspend the bullet-shaped microparticles in an aqueous solution and flow the particle suspension with a co-flow of a non-aqueous mixture. A magnetic field gradient from a permanent magnet pulls the microparticles in the transverse direction to the fluid flow, until the particles reach the interface between the immiscible fluids. We observe that upon crossing the oil-water interface, the microparticles become coated by a thin film of the aqueous fluid. When we increase the two-fluid interfacial tension by reducing surfactant concentration, we observe that the particles become trapped at the interface, and we use this observation to extract an approximate magnetic susceptibility of the manufactured non-spherical microparticles. Finally, using fluorescence imaging, we confirm the uniformity of the thin film coating along the entire curved surface of the bullet-shaped particles. To the best of our knowledge, this is the first demonstration of conformal coating of non-spherical particles using microfluidics.

Bacterial detection and identification from human synovial fluids on an integrated microfluidic system

The Analyst ◽  
2019 ◽  
Vol 144 (4) ◽  
pp. 1210-1222 ◽  
Author(s):  
Ting-Hang Liu ◽  
Shu-Shen Cheng ◽  
Huey-Ling You ◽  
Mel S. Lee ◽  
Gwo-Bin Lee
Keyword(s):  
Limit Of Detection ◽  
Microfluidic System ◽  
Joint Fluid ◽  
Bacterial Detection ◽  
Detection And Identification ◽  
System P ◽  
Colony Forming Units ◽  
Synovial Fluids ◽  
Human Joint

An integrated microfluidic system was developed for detecting and identifying four bacteria in human joint fluid with the limit of detection as low as 100 colony forming units (CFUs) per milliliter (or 20 CFUs per reaction).

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