scholarly journals Delivery of a hydrophobic phthalocyanine photosensitizer using PEGylated gold nanoparticle conjugates for the in vivo photodynamic therapy of amelanotic melanoma

2016 ◽  
Vol 15 (5) ◽  
pp. 618-625 ◽  
Author(s):  
Monica Camerin ◽  
Miguel Moreno ◽  
María J. Marín ◽  
Claire L. Schofield ◽  
Isabelle Chambrier ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Photodynamic Therapy ◽  
Gold Nanoparticle ◽  
Amelanotic Melanoma

Gold nanoparticles functionalised with PEG and a phthalocyanine photosensitiser achieved 40% no tumour regrowth and complete survival followingin vivoPDT.

The in vivo efficacy of phthalocyanine–nanoparticle conjugates for the photodynamic therapy of amelanotic melanoma

2010 ◽  
Vol 46 (10) ◽  
pp. 1910-1918 ◽  
Author(s):  
Monica Camerin ◽  
Michela Magaraggia ◽  
Marina Soncin ◽  
Giulio Jori ◽  
Miguel Moreno ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Amelanotic Melanoma ◽  
In Vivo Efficacy

scholarly journals Photosensitiser-gold nanoparticle conjugates for photodynamic therapy of cancer

2018 ◽  
Vol 17 (11) ◽  
pp. 1534-1552 ◽  
Author(s):  
Paula García Calavia ◽  
Gordon Bruce ◽  
Lluïsa Pérez-García ◽  
David A. Russell
Keyword(s):  
Gold Nanoparticles ◽  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Gold Nanoparticle ◽  
State Of The Art ◽  
The State ◽  
Photodynamic Therapy Of Cancer ◽  
Photodynamic Cancer Therapy

A review describing the state-of-the-art of the functionalisation of gold nanoparticles with photosensitisers and targeting ligands for photodynamic cancer therapy.

Augmented tumor accumulation and photothermal ablation using gold nanoparticles with a particular cellular entry orientation

2018 ◽  
Vol 33 (6) ◽  
pp. 660-675
Author(s):  
Gwang Jin Noh ◽  
Hongsuk Park ◽  
Eun Seong Lee
Keyword(s):  
Gold Nanoparticles ◽  
Tumor Cell ◽  
Gold Nanoparticle ◽  
Cellular Internalization ◽  
Tat Peptide ◽  
Peptide Expression ◽  
Cellular Entry ◽  
Tumor Accumulation

Gold nanoparticles with various functionalities have served as potential tools in nanotechnology for tumor ablation. In this work, we seek to design and develop gold nanoparticle with poly(ethylene glycol)-containing dopamine (hereafter termed as AuND), and to synthesize the AuND with one-sided Tat peptide expression (OT@AuND). We demonstrate the tumor cell-targeting ability on the basis of anti-nonspecific cell binding of OT@AuND and determine how the chemically modified gold nanoparticle–based product affects photothermal tumor therapy in vitro and in vivo. The OT@AuND with a particular cellular entry orientation–induced delayed endocytosis, which is advantageous for enhanced permeability and retention effect-based tumor accumulation. This is because the slower cellular interaction of OT@AuND allows it to have the time to be transported to and bind to the tumor site. In tumor cell lines, OT@AuND showed a lower cellular uptake than gold nanoparticles with full-sided Tat peptide expression (FT@AuND) in the early period (after its in vitro and in vivo administration), but the cellular internalization rate of OT@AuND caught up with that of FT@AuND in the late period. Importantly, the delayed cellular internalization feature of OT@AuND resulted in efficient tumor accumulation in tumor-bearing mice, because the time interval provided OT@AuND more chances not to bind to any cells, but to enter tumor cells, leading to selective photothermal tumor ablation. These data suggest that gold nanoparticles with a particular cellular entry orientation can be further explored as a potential photothermal therapeutic agent and as a strategy to treat tumors.

Radioactive Gold Nanoparticle in Two Forms (19879Au GNPs and 99mTc-GNPs) for Lung Cancer Antiproliferative Induction and Intralesional Imaging: A Proof of Concept

2020 ◽  
Vol 20 (14) ◽  
pp. 1648-1653 ◽  
Author(s):  
Hongwei Xu ◽  
Shengpan Jiang ◽  
Jimin Wang ◽  
Xuebing Li ◽  
Tingwei Wu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Gold Nanoparticles ◽  
Gold Nanoparticle ◽  
Au Nanoparticles ◽  
A549 Cells ◽  
Intralesional Injection ◽  
Proof Of Concept ◽  
Efficient Treatment

Background: Lung cancer is among the most common cancers worldwide, responsible for 13% of all new cancer cases. Also, it is the leading cause of cancer death among both men and women. In this scenario, an effective and efficient treatment is required. Objective: Production of two gold nanoparticles: 198Au and 99mTc-Au. The first one has been produced from irradiation of the 197Au in order to produce a beta-emitter gold nanoparticle for cancer therapy. The second one has been produced from the radiolabeling of gold nanoparticles with technetium 99 metastable in order to produce imaging nanoagent. Methods: The 198Au nanoparticles were produced by irradiation and identified by hyper-purity germanium (HPGe). They were then evaluated in vitro in order to confirm the behavior on cell proliferation of lung cancer cell lines by the MTT methodology using A549 cells. The 99mTc-Au nanoparticles were produced by directradiolabeling with 99mTc and evaluated in vivo as intralesional nanoagent. Results: The results showed that in both cases, all the nanoparticles have performed their duties with excellence. The 198Au nanoparticles were capable to kill lung cancer cells, while 99mTc-Au was capable to image the tumor after intralesional injection. In addition, 99mTc-Au nanoparticles were useful for biodistribution assay imaging, showing the main organs responsible for the nanoparticle uptake in healthy animals. Conclusion: Both gold nanoparticles showed to be a highly efficient nanoagent for both: therapy and diagnosing of lung cancer.

scholarly journals Highly Efficient Drug Delivery with Gold Nanoparticle Vectors for in Vivo Photodynamic Therapy of Cancer

2008 ◽  
Vol 130 (32) ◽  
pp. 10643-10647 ◽  
Author(s):  
Yu Cheng ◽  
Anna C. Samia ◽  
Joseph D. Meyers ◽  
Irene Panagopoulos ◽  
Baowei Fei ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Gold Nanoparticle ◽  
Highly Efficient ◽  
Photodynamic Therapy Of Cancer

Light-responsible DNA hydrogel–gold nanoparticle assembly for synergistic cancer therapy

2015 ◽  
Vol 3 (8) ◽  
pp. 1537-1543 ◽  
Author(s):  
Jaejung Song ◽  
Sekyu Hwang ◽  
Kyuhyun Im ◽  
Jaehyun Hur ◽  
Jutaek Nam ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Cancer Therapy ◽  
Gold Nanoparticle ◽  
Nanoparticle Assembly ◽  
Delivery Vehicle ◽  
Combination Cancer Therapy ◽  
Synergistic Combination ◽  
Dna Hydrogel

A DNA hydrogel based delivery vehicle that combines assembled gold nanoparticles and Doxorubicins showed light-triggered and synergistic combination cancer therapy at the in vitro and in vivo levels.

scholarly journals Gold Nanoparticle Mediated Phototherapy for Cancer

2016 ◽  
Vol 2016 ◽  
pp. 1-29 ◽  
Author(s):  
Cuiping Yao ◽  
Luwei Zhang ◽  
Jing Wang ◽  
Yulu He ◽  
Jing Xin ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Optical Properties ◽  
Radiation Therapy ◽  
Photodynamic Therapy ◽  
Adverse Effects ◽  
Gold Nanoparticle ◽  
Photothermal Therapy ◽  
Drug Carrier ◽  
Cancer Treatments ◽  
Medical Diagnostic

Gold nanoparticles exhibit very unique physiochemical and optical properties, which now are extensively studied in range of medical diagnostic and therapeutic applications. In particular, gold nanoparticles show promise in the advancement of cancer treatments. This review will provide insights into the four different cancer treatments such as photothermal therapy, gold nanoparticle-aided photodynamic therapy, gold nanoparticle-aided radiation therapy, and their use as drug carrier. We also discuss the mechanism of every method and the adverse effects and its limitations.

Optimization of Gold Nanoparticle Biosynthesis by Escherichia coli DH5α and its Conjugation with Gentamicin

2015 ◽  
Vol 32 ◽  
pp. 93-105 ◽  
Author(s):  
Hossein Motamedi ◽  
Samaneh Khademi Mazdeh ◽  
Azim Akbarzadeh Khiavi ◽  
Mohammad Reza Mehrabi
Keyword(s):  
Gold Nanoparticles ◽  
Gold Nanoparticle ◽  
Targeted Drug Delivery ◽  
Anaerobic Bacteria ◽  
Natural Resistance ◽  
In Vivo Studies ◽  
Optimum Conditions ◽  
E Coli ◽  
Nanoparticle Biosynthesis

Metal nanoparticles are one option for targeted drug delivery. In order to increase antibiotic efficiency and decrease its side effects, antibiotic conjugated nanoparticles have been known as a suitable approach. The aim of this study was optimization of gold nanoparticle biosynthesis byEscherichia coliDH5α and its conjugation with gentamicin. For this purpose gold nanoparticles were biosynthesized from HAuCl4and confirmed by Uv/ Vis, XRD, DLS and SEM. Then the effects of different parameters on optimum conditions for gold nanoparticles production were investigated. The MIC and MBC of gentamicin and its conjugate were investigated againstE. coli,Clostridium perfringensandClostridium botulinum. The results revealed that among different treatments, centrifuge (10000 rpm, 10 min) and sonication are the optimum conditions for gold nanoparticle production with less than 10 nm sizes. Filtration was also the best method for purifying nanoparticles. The conjugated nanoparticles significantly reduced the MIC of gentamicin againstE. coliand also overcame the natural resistance of tested anaerobic bacteria. In conclusion, the optimized method is an effective, inexpensive and environmental friendly method for biosynthesis of gold nanoparticles. Overcoming natural resistance of anaerobic bacteria using antibiotic conjugates with nanoparticles provides hopes for further experiments and in vivo studies.

Photodynamic therapy with 5-aminolaevulinic acid-induced porphyrins of an amelanotic melanoma in vivo

1997 ◽  
Vol 40 (1) ◽  
pp. 76-83 ◽  
Author(s):  
C. Abels ◽  
C. Fritsch ◽  
K. Bolsen ◽  
R.-M. Szeimies ◽  
T. Ruzicka ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Amelanotic Melanoma ◽  
Aminolaevulinic Acid

scholarly journals Towards optimisation of surface enhanced photodynamic therapy of breast cancer cells using gold nanoparticle–photosensitiser conjugates

2018 ◽  
Vol 17 (3) ◽  
pp. 281-289 ◽  
Author(s):  
Paula García Calavia ◽  
María J. Marín ◽  
Isabelle Chambrier ◽  
Michael J. Cook ◽  
David A. Russell
Keyword(s):  
Breast Cancer ◽  
Gold Nanoparticles ◽  
Cell Death ◽  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Gold Nanoparticle ◽  
Breast Cancer Cells ◽  
Enhanced Fluorescence ◽  
Surface Enhanced Fluorescence ◽  
Surface Enhanced

Surface enhanced fluorescence of zinc pthalocyanine-functionalised gold nanoparticles leads to a remarkable enhancement in photodynamic efficiency and cell death.

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