scholarly journals Highly Efficient Drug Delivery with Gold Nanoparticle Vectors for in Vivo Photodynamic Therapy of Cancer

2008 ◽  
Vol 130 (32) ◽  
pp. 10643-10647 ◽  
Author(s):  
Yu Cheng ◽  
Anna C. Samia ◽  
Joseph D. Meyers ◽  
Irene Panagopoulos ◽  
Baowei Fei ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Gold Nanoparticle ◽  
Highly Efficient ◽  
Photodynamic Therapy Of Cancer

ROS-Responsive and active targeted drug delivery based on conjugated polymer nanoparticles for synergistic chemo-/photodynamic therapy

2021 ◽  
Author(s):  
Ziqi Zhang ◽  
Zhuanning Lu ◽  
Qiong Yuan ◽  
Chen Zhang ◽  
Yanli Tang
Keyword(s):  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Targeted Drug Delivery ◽  
Conjugated Polymer ◽  
Polymer Nanoparticles ◽  
Active Targeting ◽  
Highly Efficient ◽  
Conjugated Polymer Nanoparticles ◽  
Targeted Drug

A biocompatible and ROS-responsive drug delivery nanocarrier iRGD-BDOX@CPNs with active targeting was constructed for highly efficient chemo-/photodynamic (PDT) synergistic therapy.

scholarly journals Use of Cyclodextrins in Anticancer Photodynamic Therapy Treatment

Molecules ◽  
2018 ◽  
Vol 23 (8) ◽  
pp. 1936 ◽  
Author(s):  
Amina Ben Mihoub ◽  
Ludivine Larue ◽  
Albert Moussaron ◽  
Zahraa Youssef ◽  
Ludovic Colombeau ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Molecular Oxygen ◽  
Inclusion Complexes ◽  
Water Solubility ◽  
Cellular Damage ◽  
Hybrid Nanoparticles ◽  
Binding Modes

Photodynamic therapy (PDT) is mainly used to destroy cancerous cells; it combines the action of three components: a photoactivatable molecule or photosensitizer (PS), the light of an appropriate wavelength, and naturally occurring molecular oxygen. After light excitation of the PS, the excited PS then reacts with molecular oxygen to produce reactive oxygen species (ROS), leading to cellular damage. One of the drawbacks of PSs is their lack of solubility in water and body tissue fluids, thereby causing low bioavailability, drug-delivery efficiency, therapeutic efficacy, and ROS production. To improve the water-solubility and/or drug delivery of PSs, using cyclodextrins (CDs) is an interesting strategy. This review describes the in vitro or/and in vivo use of natural and derived CDs to improve antitumoral PDT efficiency in aqueous media. To achieve these goals, three types of binding modes of PSs with CDs are developed: non-covalent CD–PS inclusion complexes, covalent CD–PS conjugates, and CD–PS nanoassemblies. This review is divided into three parts: (1) non-covalent CD-PS inclusion complexes, covalent CD–PS conjugates, and CD–PS nanoassemblies, (2) incorporating CD–PS systems into hybrid nanoparticles (NPs) using up-converting or other types of NPs, and (3) CDs with fullerenes as PSs.

scholarly journals Photosensitiser-gold nanoparticle conjugates for photodynamic therapy of cancer

2018 ◽  
Vol 17 (11) ◽  
pp. 1534-1552 ◽  
Author(s):  
Paula García Calavia ◽  
Gordon Bruce ◽  
Lluïsa Pérez-García ◽  
David A. Russell
Keyword(s):  
Gold Nanoparticles ◽  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Gold Nanoparticle ◽  
State Of The Art ◽  
The State ◽  
Photodynamic Therapy Of Cancer ◽  
Photodynamic Cancer Therapy

A review describing the state-of-the-art of the functionalisation of gold nanoparticles with photosensitisers and targeting ligands for photodynamic cancer therapy.

scholarly journals Can nanotechnology potentiate photodynamic therapy?

2012 ◽  
Vol 1 (2) ◽  
pp. 111-146 ◽  
Author(s):  
Ying-Ying Huang ◽  
Sulbha K. Sharma ◽  
Tianhong Dai ◽  
Hoon Chung ◽  
Anastasia Yaroslavsky ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Plasmonic Enhancement ◽  
Gold And Silver Nanoparticles ◽  
Drug Delivery Vehicles ◽  
Two Photon ◽  
Photon Excitation ◽  
Poorly Soluble ◽  
Delivery Vehicles

AbstractPhotodynamic therapy (PDT) uses the combination of nontoxic dyes and harmless visible light to produce reactive oxygen species that can kill cancer cells and infectious microorganisms. Due to the tendency of most photosensitizers (PS) to be poorly soluble and to form nonphotoactive aggregates, drug-delivery vehicles have become of high importance. The nanotechnology revolution has provided many examples of nanoscale drug-delivery platforms that have been applied to PDT. These include liposomes, lipoplexes, nanoemulsions, micelles, polymer nanoparticles (degradable and nondegradable), and silica nanoparticles. In some cases (fullerenes and quantum dots), the actual nanoparticle itself is the PS. Targeting ligands such as antibodies and peptides can be used to increase specificity. Gold and silver nanoparticles can provide plasmonic enhancement of PDT. Two-photon excitation or optical upconversion can be used instead of one-photon excitation to increase tissue penetration at longer wavelengths. Finally, after sections on in vivo studies and nanotoxicology, we attempt to answer the title question, “can nanotechnology potentiate PDT?”

scholarly journals Firmly anchored photosensitizer Chlorin e6 to layered double hydroxide nanoflakes for highly efficient photodynamic therapy in vivo

2017 ◽  
Vol 53 (15) ◽  
pp. 2339-2342 ◽  
Author(s):  
Li Yan ◽  
Zhigang Wang ◽  
Xianfeng Chen ◽  
Xiao-Jun Gou ◽  
Zhenyu Zhang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Polyethylene Glycol ◽  
Layered Double Hydroxide ◽  
Layered Double Hydroxides ◽  
Chlorin E6 ◽  
Therapeutic Efficiency ◽  
Highly Efficient ◽  
Double Hydroxide ◽  
Double Hydroxides

We covalently conjugate photosensitizer Chlorin e6 (Ce6) to polyethylene glycol modified layered double hydroxides and produce hybrid nanoflakes with excellentin vivophotodynamic therapeutic efficiency and safety profiles.

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