The in vivo efficacy of phthalocyanine–nanoparticle conjugates for the photodynamic therapy of amelanotic melanoma

2010 ◽  
Vol 46 (10) ◽  
pp. 1910-1918 ◽  
Author(s):  
Monica Camerin ◽  
Michela Magaraggia ◽  
Marina Soncin ◽  
Giulio Jori ◽  
Miguel Moreno ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Amelanotic Melanoma ◽  
In Vivo Efficacy

scholarly journals Delivery of a hydrophobic phthalocyanine photosensitizer using PEGylated gold nanoparticle conjugates for the in vivo photodynamic therapy of amelanotic melanoma

2016 ◽  
Vol 15 (5) ◽  
pp. 618-625 ◽  
Author(s):  
Monica Camerin ◽  
Miguel Moreno ◽  
María J. Marín ◽  
Claire L. Schofield ◽  
Isabelle Chambrier ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Photodynamic Therapy ◽  
Gold Nanoparticle ◽  
Amelanotic Melanoma

Gold nanoparticles functionalised with PEG and a phthalocyanine photosensitiser achieved 40% no tumour regrowth and complete survival followingin vivoPDT.

In vivo efficacy of photodynamic therapy in three new xenograft models of human retinoblastoma

2010 ◽  
Vol 7 (4) ◽  
pp. 275-283 ◽  
Author(s):  
Isabelle Aerts ◽  
Pascal Leuraud ◽  
Jocelyne Blais ◽  
Anne-lise Pouliquen ◽  
Philippe Maillard ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
In Vivo Efficacy ◽  
Human Retinoblastoma ◽  
Xenograft Models

648 In vivo efficacy of photodynamic therapy in xenografts of retinoblatoma

2004 ◽  
Vol 2 (8) ◽  
pp. 195
Author(s):  
P. Leuraud ◽  
L. Taillandier ◽  
J. Medioni ◽  
J.-Y. Delattre ◽  
M. Sanson ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
In Vivo Efficacy

Photodynamic therapy with 5-aminolaevulinic acid-induced porphyrins of an amelanotic melanoma in vivo

1997 ◽  
Vol 40 (1) ◽  
pp. 76-83 ◽  
Author(s):  
C. Abels ◽  
C. Fritsch ◽  
K. Bolsen ◽  
R.-M. Szeimies ◽  
T. Ruzicka ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Amelanotic Melanoma ◽  
Aminolaevulinic Acid

Ultrastructural observations on the in vitro cytoadherence of Plasmodium falciparum infected red blood cells

1990 ◽  
Vol 48 (3) ◽  
pp. 914-915
Author(s):  
D.J.P. Ferguson ◽  
A.R. Berendt ◽  
J. Tansey ◽  
K. Marsh ◽  
C.I. Newbold
Keyword(s):  
Plasmodium Falciparum ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Umbilical Vein ◽  
Cell Types ◽  
Amelanotic Melanoma ◽  
Cytoplasmic Process ◽  
Umbilical Vein Endothelial Cells

In human malaria, the most serious clinical manifestation is cerebral malaria (CM) due to infection with Plasmodium falciparum. The pathology of CM is thought to relate to the fact that red blood cells containing mature forms of the parasite (PRBC) cytoadhere or sequester to post capillary venules of various tissues including the brain. This in vivo phenomenon has been studied in vitro by examining the cytoadherence of PRBCs to various cell types and purified proteins. To date, three Ijiost receptor molecules have been identified; CD36, ICAM-1 and thrombospondin. The specific changes in the PRBC membrane which mediate cytoadherence are less well understood, but they include the sub-membranous deposition of electron-dense material resulting in surface deformations called knobs. Knobs were thought to be essential for cytoadherence, lput recent work has shown that certain knob-negative (K-) lines can cytoadhere. In the present study, we have used electron microscopy to re-examine the interactions between K+ PRBCs and both C32 amelanotic melanoma cells and human umbilical vein endothelial cells (HUVEC).We confirm previous data demonstrating that C32 cells possess numerous microvilli which adhere to the PRBC, mainly via the knobs (Fig. 1). In contrast, the HUVEC were relatively smooth and the PRBCs appeared partially flattened onto the cell surface (Fig. 2). Furthermore, many of the PRBCs exhibited an invagination of the limiting membrane in the attachment zone, often containing a cytoplasmic process from the endothelial cell (Fig. 2).

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