A block copolymer containing PEG and histamine-like segments: well-defined functions for gene delivery

2016 ◽  
Vol 40 (8) ◽  
pp. 7222-7228 ◽  
Author(s):  
Junbo Li ◽  
Jianlong Zhao ◽  
Jiayu Gao ◽  
Ju Liang ◽  
Wenlan Wu ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Gene Delivery ◽  
Colloidal Stability ◽  
Gene Transfection ◽  
Buffering Capacity ◽  
Dna Condensation ◽  
Lower Toxicity ◽  
Efficient Gene

PEG-b-PAMPImB with well-defined functions, including high colloidal stability, effective DNA condensation and buffering capacity, self-assembles with pDNA for lower toxicity and higher efficient gene transfection.

Preparation of pH-sensitive CaP nanoparticles coated with a phosphate-based block copolymer for efficient gene delivery

Polymer ◽  
2012 ◽  
Vol 53 (21) ◽  
pp. 4678-4685 ◽  
Author(s):  
Sangmok Jang ◽  
Seonju Lee ◽  
Heejin Kim ◽  
Jiyeon Ham ◽  
Ji-Hun Seo ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Gene Delivery ◽  
Ph Sensitive ◽  
Efficient Gene

scholarly journals Ionic liquids with thioether motifs as synthetic cationic lipids for gene delivery

2017 ◽  
Vol 53 (59) ◽  
pp. 8328-8331 ◽  
Author(s):  
Jamie C. Gaitor ◽  
Lauren M. Paul ◽  
Melissa M. Reardon ◽  
Taha Hmissa ◽  
Samuel Minkowicz ◽  
...  
Keyword(s):  
Ionic Liquids ◽  
Gene Delivery ◽  
Click Chemistry ◽  
Gene Transfection ◽  
Cationic Lipids ◽  
Efficient Gene

Novel lipidic ionic liquids with imidazolium headgroups (red), thioether linkers (black), and two hydrophobic tails (blue) as efficient gene transfection vectors, synthesized via thiol–yne click chemistry.

Dual-functionalized calcium carbonate based gene delivery system for efficient gene delivery

RSC Advances ◽  
2014 ◽  
Vol 4 (73) ◽  
pp. 38623-38629 ◽  
Author(s):  
Chao-Qun Wang ◽  
Meng-Qing Gong ◽  
Jin-Long Wu ◽  
Ren-Xi Zhuo ◽  
Si-Xue Cheng
Keyword(s):  
Calcium Carbonate ◽  
Gene Delivery ◽  
Delivery System ◽  
Gene Transfection ◽  
Cell Penetrating Peptide ◽  
Gene Delivery System ◽  
Dna Nanoparticles ◽  
Efficient Gene ◽  
Cell Penetrating ◽  
A Cell

Dual-functionalized KALA/PS/CaCO3/DNA nanoparticles containing a cell penetrating peptide (KALA) and protamine sulfate (PS) could effectively mediate gene transfection at a low DNA concentration.

scholarly journals Hydrazone-modulated peptides for efficient gene transfection

2017 ◽  
Vol 5 (23) ◽  
pp. 4426-4434 ◽  
Author(s):  
Iria Louzao ◽  
Rebeca García-Fandiño ◽  
Javier Montenegro
Keyword(s):  
Hela Cells ◽  
Plasmid Dna ◽  
Gene Transfection ◽  
Bond Formation ◽  
Lower Toxicity ◽  
Amphiphilic Peptides ◽  
Efficient Gene ◽  
Plasmid Transfection

The synthetic potential of dynamic bond formation is introduced for the delivery of plasmid DNA by modulated amphiphilic peptides. The synthetic advantage of these dynamic bonds allowed the identification of improved reagents (better efficiency and lower toxicity) for plasmid transfection assays in human HeLa cells.

Efficient and safe gene transfection in fish spermatogonial stem cells using nanomaterials

RSC Advances ◽  
2016 ◽  
Vol 6 (58) ◽  
pp. 52636-52641 ◽  
Author(s):  
F. M. P. Tonelli ◽  
S. M. S. N. Lacerda ◽  
N. C. O. Paiva ◽  
M. S. Lemos ◽  
A. C. de Jesus ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cell Death ◽  
Gene Delivery ◽  
Nile Tilapia ◽  
Gene Transfection ◽  
Spermatogonial Stem Cells ◽  
Efficient Gene

The nanomaterials MWCNTs, NGO and NRs can be functionalized and complexed to DNA to promote efficient gene delivery to Nile tilapia spermatogonial stem cells inducing less cell death than electroporation and the commercial reagents tested.

Construction of traceable cucurbit[7]uril-based virus-mimicking quaternary complexes with aggregation-induced emission for efficient gene transfection

2020 ◽  
Vol 8 (33) ◽  
pp. 7475-7482
Author(s):  
De-E Liu ◽  
Xiangjie Yan ◽  
Jinxia An ◽  
Jianbiao Ma ◽  
Hui Gao
Keyword(s):  
Gene Delivery ◽  
Delivery System ◽  
Gene Transfection ◽  
Delivery Systems ◽  
Endosomal Escape ◽  
Gene Delivery System ◽  
Aggregation Induced Emission ◽  
Efficient Gene ◽  
Novel Virus

A novel virus-mimicking gene delivery system with excellent endosomal escape, efficient transfection, and traceability is developed which can serve as a reference for the construction of novel multifunctional efficient gene delivery systems.

scholarly journals Aromatic Thioacetal-Bridged ROS-Responsive Nanoparticles as Novel Gene Delivery Vehicles

Molecules ◽  
2018 ◽  
Vol 23 (8) ◽  
pp. 2061 ◽  
Author(s):  
Guo-Qing Lin ◽  
Wen-Jing Yi ◽  
Qiang Liu ◽  
Xue-Jun Yang ◽  
Zhi-Gang Zhao
Keyword(s):  
Gene Delivery ◽  
Transfection Efficiency ◽  
Gene Transfection ◽  
Zeta Potentials ◽  
Sar Studies ◽  
Gene Delivery Vectors ◽  
Efficient Gene ◽  
Delivery Vehicles ◽  
Low Cytotoxicity

In this report, a series of polycations are designed and synthesized by conjugating reactive oxygen species (ROS)-responsive thioacetal-linkers to low molecular weight (LMW) polyethylenimine (PEI) via ring-opening polymerization. Their structure–activity relationships (SARs) as gene delivery vectors are systematically studied. Although the MWs of the target polymers are only ~9 KDa, they show good DNA binding ability. The formed polyplexes, which are stable toward serum but decomposed under ROS-conditions, have appropriate sizes (180~300 nm) and positive zeta-potentials (+35~50 mV). In vitro experiments reveal that these materials have low cytotoxicity, and higher transfection efficiency (TE) than controls. Furthermore, the title polymers exhibit excellent serum tolerance. With the present of 10% serum, the TE of the polymers even increases up to 10 times higher than 25 KDa PEI and 9 times higher than Lipofectamine 2000. The SAR studies also reveal that electron-withdrawing groups on the aromatic ring in 4a may benefit to balance between the DNA condensation and release for efficient gene transfection.

scholarly journals Tuning the Buffering Capacity of Polyethylenimine with Glycerol Molecules for Efficient Gene Delivery: Staying In or Out of the Endosomes

2015 ◽  
Vol 15 (5) ◽  
pp. 622-635 ◽  
Author(s):  
Bijay Singh ◽  
Sushila Maharjan ◽  
Tae-Eun Park ◽  
Tao Jiang ◽  
Sang-Kee Kang ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Buffering Capacity ◽  
Efficient Gene
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