scholarly journals Hydrazone-modulated peptides for efficient gene transfection

2017 ◽  
Vol 5 (23) ◽  
pp. 4426-4434 ◽  
Author(s):  
Iria Louzao ◽  
Rebeca García-Fandiño ◽  
Javier Montenegro
Keyword(s):  
Hela Cells ◽  
Plasmid Dna ◽  
Gene Transfection ◽  
Bond Formation ◽  
Lower Toxicity ◽  
Amphiphilic Peptides ◽  
Efficient Gene ◽  
Plasmid Transfection

The synthetic potential of dynamic bond formation is introduced for the delivery of plasmid DNA by modulated amphiphilic peptides. The synthetic advantage of these dynamic bonds allowed the identification of improved reagents (better efficiency and lower toxicity) for plasmid transfection assays in human HeLa cells.

A block copolymer containing PEG and histamine-like segments: well-defined functions for gene delivery

2016 ◽  
Vol 40 (8) ◽  
pp. 7222-7228 ◽  
Author(s):  
Junbo Li ◽  
Jianlong Zhao ◽  
Jiayu Gao ◽  
Ju Liang ◽  
Wenlan Wu ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Gene Delivery ◽  
Colloidal Stability ◽  
Gene Transfection ◽  
Buffering Capacity ◽  
Dna Condensation ◽  
Lower Toxicity ◽  
Efficient Gene

PEG-b-PAMPImB with well-defined functions, including high colloidal stability, effective DNA condensation and buffering capacity, self-assembles with pDNA for lower toxicity and higher efficient gene transfection.

scholarly journals Chitosan-conjugated lipid microbubble combined with ultrasound for efficient gene transfection

2018 ◽  
Vol 32 (4) ◽  
pp. 982-987 ◽  
Author(s):  
Hui Zhang ◽  
Jiawei Tu ◽  
Yangying Liao ◽  
Kuan Cai ◽  
Yue Li ◽  
...  
Keyword(s):  
Gene Transfection ◽  
Efficient Gene

scholarly journals Ionic liquids with thioether motifs as synthetic cationic lipids for gene delivery

2017 ◽  
Vol 53 (59) ◽  
pp. 8328-8331 ◽  
Author(s):  
Jamie C. Gaitor ◽  
Lauren M. Paul ◽  
Melissa M. Reardon ◽  
Taha Hmissa ◽  
Samuel Minkowicz ◽  
...  
Keyword(s):  
Ionic Liquids ◽  
Gene Delivery ◽  
Click Chemistry ◽  
Gene Transfection ◽  
Cationic Lipids ◽  
Efficient Gene

Novel lipidic ionic liquids with imidazolium headgroups (red), thioether linkers (black), and two hydrophobic tails (blue) as efficient gene transfection vectors, synthesized via thiol–yne click chemistry.

Functionalized Scaffold for in Situ Efficient Gene Transfection of Mesenchymal Stem Cells Spheroids toward Chondrogenesis

2018 ◽  
Vol 10 (40) ◽  
pp. 33993-34004 ◽  
Author(s):  
Kunxi Zhang ◽  
Haowei Fang ◽  
Yechi Qin ◽  
Lili Zhang ◽  
Jingbo Yin
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Gene Transfection ◽  
Efficient Gene

A PEG-b-poly(disulfide-l-lysine) based redox-responsive cationic polymer for efficient gene transfection

2019 ◽  
Vol 7 (11) ◽  
pp. 1893-1905 ◽  
Author(s):  
Ihsan Ullah ◽  
Jing Zhao ◽  
Shah Rukh ◽  
Khan Muhammad ◽  
Jintang Guo ◽  
...  
Keyword(s):  
Gene Transfection ◽  
Cationic Polymer ◽  
Endosomal Escape ◽  
Gene Vector ◽  
Efficient Gene ◽  
Redox Responsive ◽  
Responsive Gene

A redox responsive gene vector efficiently delivered pDNA with a good internalization tendency, efficient endosomal escape and high nucleus internalization.

scholarly journals Cyclopropenium Nanoparticles and Gene Transfection in Cells

Pharmaceutics ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 768
Author(s):  
Noam Y. Steinman ◽  
Luis M. Campos ◽  
Yakai Feng ◽  
Abraham J. Domb ◽  
Hossein Hosseinkhani
Keyword(s):  
Viral Vectors ◽  
Gene Transfection ◽  
Medical Science ◽  
Genetic Material ◽  
Mouse Fibroblast ◽  
Ethylene Imine ◽  
Efficient Gene ◽  
Poly Ethylene ◽  
First Time

Non-viral vectors for the transfection of genetic material are at the frontier of medical science. In this article, we introduce for the first time, cyclopropenium-containing nanoparticles as a cationic carrier for gene transfection, as an alternative to the common quaternary ammonium transfection agents. Cyclopropenium-based cationic nanoparticles were prepared by crosslinking poly(ethylene imine) (PEI) with tetrachlorocyclopropene. These nanoparticles were electrostatically complexed with plasmid DNA into nanoparticles (~50 nm). Their cellular uptake into F929 mouse fibroblast cells, and their eventual expression in vitro have been described. Transfection is enhanced relative to PEI with minimal toxicity. These cyclopropenium nanoparticles possess efficient gene transfection capabilities with minimal cytotoxicity, which makes them novel and promising candidates for gene therapy.

α-Tocopherol derived lipid dimers as efficient gene transfection agents. Mechanistic insights into lipoplex internalization and therapeutic induction of apoptotic activity

2015 ◽  
Vol 13 (8) ◽  
pp. 2444-2452 ◽  
Author(s):  
Krishan Kumar ◽  
Bappa Maiti ◽  
Paturu Kondaiah ◽  
Santanu Bhattacharya
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Gene Transfection ◽  
Dna Delivery ◽  
Cancer Cell Lines ◽  
Efficient Gene ◽  
Apoptotic Activity

Dimeric cationic tocopheryl lipids for efficacious therapeutic pDNA delivery in cancer cell lines.

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