Preparation of pH-sensitive CaP nanoparticles coated with a phosphate-based block copolymer for efficient gene delivery

Polymer ◽  
2012 ◽  
Vol 53 (21) ◽  
pp. 4678-4685 ◽  
Author(s):  
Sangmok Jang ◽  
Seonju Lee ◽  
Heejin Kim ◽  
Jiyeon Ham ◽  
Ji-Hun Seo ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Gene Delivery ◽  
Ph Sensitive ◽  
Efficient Gene

A block copolymer containing PEG and histamine-like segments: well-defined functions for gene delivery

2016 ◽  
Vol 40 (8) ◽  
pp. 7222-7228 ◽  
Author(s):  
Junbo Li ◽  
Jianlong Zhao ◽  
Jiayu Gao ◽  
Ju Liang ◽  
Wenlan Wu ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Gene Delivery ◽  
Colloidal Stability ◽  
Gene Transfection ◽  
Buffering Capacity ◽  
Dna Condensation ◽  
Lower Toxicity ◽  
Efficient Gene

PEG-b-PAMPImB with well-defined functions, including high colloidal stability, effective DNA condensation and buffering capacity, self-assembles with pDNA for lower toxicity and higher efficient gene transfection.

Amino acids functionalized dendrimers with nucleus accumulation for efficient gene delivery

2021 ◽  
pp. 120641
Author(s):  
Guoxin Tan ◽  
Jiayang Li ◽  
Dandan Liu ◽  
Hao Pan ◽  
Renfang Zhu ◽  
...  
Keyword(s):  
Amino Acids ◽  
Gene Delivery ◽  
Efficient Gene

scholarly journals Carbon Dot Nanoparticles: Exploring the Potential Use for Gene Delivery in Ophthalmic Diseases

Nanomaterials ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 935
Author(s):  
Manas R. Biswal ◽  
Sofia Bhatia
Keyword(s):  
Gene Delivery ◽  
Therapeutic Option ◽  
Retinal Dystrophy ◽  
Retinal Cells ◽  
Adeno Associated Virus ◽  
Inherited Retinal Dystrophies ◽  
Retinal Dystrophies ◽  
Efficient Gene ◽  
New Type ◽  
Viral Nanoparticles

Ocular gene therapy offers significant potential for preventing retinal dystrophy in patients with inherited retinal dystrophies (IRD). Adeno-associated virus (AAV) based gene transfer is the most common and successful gene delivery approach to the eye. These days, many studies are using non-viral nanoparticles (NPs) as an alternative therapeutic option because of their unique properties and biocompatibility. Here, we discuss the potential of carbon dots (CDs), a new type of nanocarrier for gene delivery to the retinal cells. The unique physicochemical properties of CDs (such as optical, electronic, and catalytic) make them suitable for biosensing, imaging, drug, and gene delivery applications. Efficient gene delivery to the retinal cells using CDs depends on various factors, such as photoluminescence, quantum yield, biocompatibility, size, and shape. In this review, we focused on different approaches used to synthesize CDs, classify CDs, various pathways for the intake of gene-loaded carbon nanoparticles inside the cell, and multiple studies that worked on transferring nucleic acid in the eye using CDs.

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