scholarly journals Fluorescent transmembrane anion transporters: shedding light on anionophoric activity in cells

2016 ◽  
Vol 7 (8) ◽  
pp. 5069-5077 ◽  
Author(s):  
Stuart N. Berry ◽  
Vanessa Soto-Cerrato ◽  
Ethan N. W. Howe ◽  
Harriet J. Clarke ◽  
Ishna Mistry ◽  
...  
Keyword(s):  
Transport Properties ◽  
Cell Lines ◽  
Cancer Cell ◽  
Cancer Cell Lines ◽  
Anion Transport ◽  
Anion Transporters ◽  
In Cells

A series of fluorescent anion transporters have been synthesised and their anion transport properties and interactions with cancer cell lines studied.

Immunocytochemical demonstration of collagen types I and IV in cells isolated from malignant mesothelioma and in lung cancer cell lines

Lung Cancer ◽  
1990 ◽  
Vol 6 (1-2) ◽  
pp. 16-27 ◽  
Author(s):  
H. Kataoka ◽  
B. Wikström ◽  
J. Klominek ◽  
R.E. Gay ◽  
S. Gay ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Malignant Mesothelioma ◽  
Cancer Cell Lines ◽  
Lung Cancer Cell ◽  
Collagen Types ◽  
In Cells

Transmembrane anion transport and cytotoxicity of synthetic tambjamine analogs

2014 ◽  
Vol 12 (11) ◽  
pp. 1771-1778 ◽  
Author(s):  
Elsa Hernando ◽  
Vanessa Soto-Cerrato ◽  
Susana Cortés-Arroyo ◽  
Ricardo Pérez-Tomás ◽  
Roberto Quesada
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Cancer Cell Lines ◽  
Anion Transport ◽  
Highly Efficient

Synthetic tambjamine analogs bearing aromatic enamine moieties are highly efficient transmembrane anion carriers, triggering apoptosis in several cancer cell lines.

scholarly journals Sorafenib decreases proliferation and induces apoptosis of prostate cancer cells by inhibition of the androgen receptor and Akt signaling pathways

2012 ◽  
Vol 19 (3) ◽  
pp. 305-319 ◽  
Author(s):  
Su Jung Oh ◽  
Holger H H Erb ◽  
Alfred Hobisch ◽  
Frédéric R Santer ◽  
Zoran Culig
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cell Lines ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Cancer Cell Lines ◽  
Prostate Cancer Cell Lines ◽  
Inhibition Of Proliferation ◽  
Prostate Cancers ◽  
In Cells

Antihormonal and chemotherapy are standard treatments for nonorgan-confined prostate cancer. The effectivity of these therapies is limited and the development of alternative approaches is necessary. In the present study, we report on the use of the multikinase inhibitor sorafenib in a panel of prostate cancer cell lines and their derivatives which mimic endocrine and chemotherapy resistance. 3H-thymidine incorporation assays revealed that sorafenib causes a dose-dependent inhibition of proliferation of all cell lines associated with downregulation of cyclin-dependent kinase 2 and cyclin D1 expression. Apoptosis was induced at 2 μM of sorafenib in androgen-sensitive cells, whereas a higher dose of the drug was needed in castration-resistant cell lines. Sorafenib stimulated apoptosis in prostate cancer cell lines through downregulation of myeloid cell leukemia-1 (MCL-1) expression and Akt phosphorylation. Although concentrations of sorafenib required for the antitumor effect in therapy-resistant sublines were higher than those needed in parental cells, the drug showed efficacy in cells which became resistant to bicalutamide and docetaxel respectively. Most interestingly, we show that sorafenib has an inhibitory effect on androgen receptor (AR) and prostate-specific antigen expression. In cells in which AR expression was downregulated by short interfering RNA, the treatment with sorafenib increased apoptosis in an additive manner. In summary, the results of the present study indicate that there is a potential to use sorafenib in prostate cancers as an adjuvant therapy option to current androgen ablation treatments, but also in progressed prostate cancers that become unresponsive to standard therapies.

Arsenic trioxide-induced apoptosis through oxidative stress in cells of colon cancer cell lines

Life Sciences ◽  
2002 ◽  
Vol 70 (19) ◽  
pp. 2253-2269 ◽  
Author(s):  
Yoshihito Nakagawa ◽  
Yukihiro Akao ◽  
Hiroshi Morikawa ◽  
Ichiro Hirata ◽  
Kenichi Katsu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Colon Cancer ◽  
Arsenic Trioxide ◽  
Cell Lines ◽  
Cancer Cell ◽  
Cancer Cell Lines ◽  
Colon Cancer Cell ◽  
Colon Cancer Cell Lines ◽  
Induced Apoptosis ◽  
In Cells

scholarly journals Delayed Chromosome Alignment to the Spindle Equator Increases the Rate of Chromosome Missegregation in Cancer Cell Lines

Biomolecules ◽  
2018 ◽  
Vol 9 (1) ◽  
pp. 10 ◽  
Author(s):  
Kinue Kuniyasu ◽  
Kenji Iemura ◽  
Kozo Tanaka
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Cancer Cell Lines ◽  
Chromosome Missegregation ◽  
Spindle Poles ◽  
Anaphase Onset ◽  
Sister Chromatids ◽  
Chromosome Congression ◽  
Chromosome Alignment ◽  
In Cells

For appropriate chromosome segregation, kinetochores on sister chromatids have to attach to microtubules from opposite spindle poles (bi-orientation). Chromosome alignment at the spindle equator, referred to as congression, can occur through the attachment of kinetochores to the lateral surface of spindle microtubules, facilitating bi-orientation establishment. However, the contribution of this phenomenon to mitotic fidelity has not been clarified yet. Here, we addressed whether delayed chromosome alignment to the spindle equator increases the rate of chromosome missegregation. Cancer cell lines depleted of Kid, a chromokinesin involved in chromosome congression, showed chromosome alignment with a slight delay, and increased frequency of lagging chromosomes. Delayed chromosome alignment concomitant with an increased rate of lagging chromosomes was also seen in cells depleted of kinesin family member 4A (KIF4A), another chromokinesin. Cells that underwent chromosome missegregation took relatively longer time to align chromosomes in both control and Kid/KIF4A-depleted cells. Tracking of late-aligning chromosomes showed that they exhibit a higher rate of lagging chromosomes. Intriguingly, the metaphase of cells that underwent chromosome missegregation was shortened, and delaying anaphase onset ameliorated the increased chromosome missegregation. These data suggest that late-aligning chromosomes do not have sufficient time to establish bi-orientation, leading to chromosome missegregation. Our data imply that delayed chromosome alignment is not only a consequence, but also a cause of defective bi-orientation establishment, which can lead to chromosomal instability in cells without severe mitotic defects.

797: Noggin Blocks the Osteoinductive Properties of Human Prostate Cancer Cell Lines

2006 ◽  
Vol 175 (4S) ◽  
pp. 258-258
Author(s):  
Ruth Schwaninger ◽  
Cyrill A. Rentsch ◽  
Antoinette Wetterwald ◽  
Irena Klima ◽  
Gabri Van der Pluijm ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Cancer Cell Lines ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Human Prostate Cancer Cell ◽  
Prostate Cancer Cell Lines
Sign in / Sign up

Export Citation Format

Share Document