High-yield, large-scale production of few-layer graphene flakes within seconds: using chlorosulfonic acid and H2O2 as exfoliating agents

2012 ◽  
Vol 22 (18) ◽  
pp. 8775 ◽  
Author(s):  
Wenbo Lu ◽  
Sen Liu ◽  
Xiaoyun Qin ◽  
Lei Wang ◽  
Jingqi Tian ◽  
...  
Keyword(s):  
Large Scale ◽  
Chlorosulfonic Acid ◽  
High Yield ◽  
Scale Production ◽  
Layer Graphene ◽  
Large Scale Production ◽  
Graphene Flakes ◽  
Few Layer Graphene

scholarly journals Progress on Diamane and Diamanoid Thin Film Pressureless Synthesis

2021 ◽  
Vol 7 (1) ◽  
pp. 9
Author(s):  
Fabrice Piazza ◽  
Marc Monthioux ◽  
Pascal Puech ◽  
Iann C. Gerber ◽  
Kathleen Gough
Keyword(s):  
Density Functional ◽  
Large Scale ◽  
Density Functional Theory Calculations ◽  
Wide Band ◽  
Scale Production ◽  
Layer Graphene ◽  
Large Scale Production ◽  
Bernal Stacking ◽  
Hydrogen Radicals ◽  
Few Layer Graphene

Nanometer-thick and crystalline sp3-bonded carbon sheets are promising new wide band-gap semiconducting materials for electronics, photonics, and medical devices. Diamane was prepared from the exposure of bi-layer graphene to hydrogen radicals produced by the hot-filament process at low pressure and temperature. A sharp sp3-bonded carbon stretching mode was observed in ultraviolet Raman spectra at around 1344–1367 cm−1 while no sp2-bonded carbon peak was simultaneously detected. By replacing bi-layer graphene with few-layer graphene, diamanoid/graphene hybrids were formed from the partial conversion of few-layer graphene, due to the prevalent Bernal stacking sequence. Raman spectroscopy, electron diffraction, and Density Functional Theory calculations show that partial conversion generates twisted bi-layer graphene located at the interface between the upper diamanoid domain and the non-converted graphenic domain underneath. Carbon-hydrogen bonding in the basal plane of hydrogenated few-layer graphene, where carbon is bonded to a single hydrogen over an area of 150 μm2, was directly evidenced by Fourier transform infrared microscopy and the actual full hydrogenation of diamane was supported by first-principle calculations. Those results open the door to large-scale production of diamane, diamanoids, and diamanoid/graphene hybrids.

Simultaneous electrochemical-assisted exfoliation and in situ surface functionalization towards large-scale production of few-layer graphene

FlatChem ◽  
2019 ◽  
Vol 18 ◽  
pp. 100132 ◽  
Author(s):  
Omid Zabihi ◽  
Mojtaba Ahmadi ◽  
Quanxiang Li ◽  
Seyed Mousa Fakhrhoseini ◽  
Zahra Komeily Nia ◽  
...  
Keyword(s):  
Surface Functionalization ◽  
Large Scale ◽  
Scale Production ◽  
Layer Graphene ◽  
Large Scale Production ◽  
Few Layer Graphene

Synthesis of few-layer graphene-like nanosheets from glucose: New facile approach for graphene-like nanosheets large-scale production

2016 ◽  
Vol 31 (4) ◽  
pp. 455-467 ◽  
Author(s):  
Marwa Adel ◽  
Azza El-Maghraby ◽  
Ossama El-Shazly ◽  
El-Wahidy F. El-Wahidy ◽  
Marwa A. A. Mohamed
Keyword(s):  
Large Scale ◽  
Scale Production ◽  
Layer Graphene ◽  
Large Scale Production ◽  
Image Position ◽  
Few Layer Graphene

Abstract

scholarly journals Large-Scale Production of Human iPSC-Derived Macrophages for Drug Screening

2020 ◽  
Vol 21 (13) ◽  
pp. 4808 ◽  
Author(s):  
Simon Gutbier ◽  
Florian Wanke ◽  
Nadine Dahm ◽  
Anna Rümmelin ◽  
Silke Zimmermann ◽  
...  
Keyword(s):  
Drug Screening ◽  
Large Scale ◽  
Neoplastic Cell ◽  
Leukemic Cells ◽  
High Yield ◽  
Scale Production ◽  
Large Scale Production ◽  
Compound Screening ◽  
Health And Disease ◽  
Induced Pluripotent

Tissue-resident macrophages are key players in inflammatory processes, and their activation and functionality are crucial in health and disease. Numerous diseases are associated with alterations in homeostasis or dysregulation of the innate immune system, including allergic reactions, autoimmune diseases, and cancer. Macrophages are a prime target for drug discovery due to their major regulatory role in health and disease. Currently, the main sources of macrophages used for therapeutic compound screening are primary cells isolated from blood or tissue or immortalized or neoplastic cell lines (e.g., THP-1). Here, we describe an improved method to employ induced pluripotent stem cells (iPSCs) for the high-yield, large-scale production of cells resembling tissue-resident macrophages. For this, iPSC-derived macrophage-like cells are thoroughly characterized to confirm their cell identity and thus their suitability for drug screening purposes. These iPSC-derived macrophages show strong cellular identity with primary macrophages and recapitulate key functional characteristics, including cytokine release, phagocytosis, and chemotaxis. Furthermore, we demonstrate that genetic modifications can be readily introduced at the macrophage-like progenitor stage in order to interrogate drug target-relevant pathways. In summary, this novel method overcomes previous shortcomings with primary and leukemic cells and facilitates large-scale production of genetically modified iPSC-derived macrophages for drug screening applications.

scholarly journals Metabolic engineering for high yield synthesis of astaxanthin in Xanthophyllomyces dendrorhous

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Alejandro Torres-Haro ◽  
Jorge Verdín ◽  
Manuel R. Kirchmayr ◽  
Melchor Arellano-Plaza
Keyword(s):  
Metabolic Engineering ◽  
Large Scale ◽  
Dry Mass ◽  
High Yield ◽  
Xanthophyllomyces Dendrorhous ◽  
Scale Production ◽  
Proteomic Data ◽  
Large Scale Production ◽  
Mutant Strains ◽  
Pharmaceutical Industries

AbstractAstaxanthin is a carotenoid with a number of assets useful for the food, cosmetic and pharmaceutical industries. Nowadays, it is mainly produced by chemical synthesis. However, the process leads to an enantiomeric mixture where the biologically assimilable forms (3R, 3′R or 3S, 3′S) are a minority. Microbial production of (3R, 3′R) astaxanthin by Xanthophyllomyces dendrorhous is an appealing alternative due to its fast growth rate and easy large-scale production. In order to increase X. dendrorhous astaxanthin yields, random mutant strains able to produce from 6 to 10 mg/g dry mass have been generated; nevertheless, they often are unstable. On the other hand, site-directed mutant strains have also been obtained, but they increase only the yield of non-astaxanthin carotenoids. In this review, we insightfully analyze the metabolic carbon flow converging in astaxanthin biosynthesis and, by integrating the biological features of X. dendrorhous with available metabolic, genomic, transcriptomic, and proteomic data, as well as the knowledge gained with random and site-directed mutants that lead to increased carotenoids yield, we propose new metabolic engineering targets to increase astaxanthin biosynthesis.

scholarly journals Toward high production of graphene flakes – a review on recent developments in their synthesis methods and scalability

2018 ◽  
Vol 6 (31) ◽  
pp. 15010-15026 ◽  
Author(s):  
Muhammad Izhar Kairi ◽  
Sebastian Dayou ◽  
Nurul Izni Kairi ◽  
Suriani Abu Bakar ◽  
Brigitte Vigolo ◽  
...  
Keyword(s):  
Large Scale ◽  
Synthesis Methods ◽  
Scale Production ◽  
Large Scale Production ◽  
Graphene Flakes ◽  
Recent Developments ◽  
High Production ◽  
Cost Of Production ◽  
The Cost

Graphene flakes, one of the most popular form of graphene, can be used for many applications. Their synthesis is in the path to reach the large-scale production if the cost of production is further improved.

scholarly journals Fabrication of Nanosize ZnO and Zn1−xFexO Powder for Infrared Absorption by Flame Aerosol Synthesis

Crystals ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 904
Author(s):  
Hui Tian ◽  
Lei Wang ◽  
Taisheng Yang ◽  
Zili Zhang
Keyword(s):  
Infrared Absorption ◽  
Large Scale ◽  
Low Cost ◽  
High Yield ◽  
Synthesis Methods ◽  
Scale Production ◽  
Absorption Properties ◽  
Aerosol Synthesis ◽  
Large Scale Production ◽  
Significant Difference

In this study, nanosized ZnO and Zn1−xFexO powders were synthesized using the flame aerosol synthesis (FAS) method. The microstructure of the ZnO powder shows a significant difference with different precursor concentrations. By adding Fe to the precursor, nanosized Zn1−xFexO powder (x = 0~0.1) can be easily fabricated. The phase formation, microstructure, and infrared absorption properties were systematically investigated by XRD, SEM, TEM, and IR. With the substitution of Fe into the Zn site, lattice distortion occurred, resulting in excellent infrared absorption properties. Compared to other conventional synthesis methods, the FAS method has the advantages of high yield, high crystallinity, and low cost; furthermore, nanosized powder is easily obtained. The FAS method is believed to be one of the best choices for the large-scale production of ZnO and Zn1−xFexO powders.

The large-scale production of graphene flakes using magnetically-enhanced arc discharge between carbon electrodes

Carbon ◽  
2010 ◽  
Vol 48 (15) ◽  
pp. 4570-4574 ◽  
Author(s):  
I. Levchenko ◽  
O. Volotskova ◽  
A. Shashurin ◽  
Y. Raitses ◽  
K. Ostrikov ◽  
...  
Keyword(s):  
Large Scale ◽  
Arc Discharge ◽  
Carbon Electrodes ◽  
Scale Production ◽  
Large Scale Production ◽  
Graphene Flakes
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