Pyrrolo-dC oligonucleotides bearing alkynyl side chains with terminal triple bonds: synthesis, base pairing and fluorescent dye conjugates prepared by the azide–alkyne “click” reaction

2008 ◽  
Vol 6 (9) ◽  
pp. 1674 ◽  
Author(s):  
Frank Seela ◽  
Venkata Ramana Sirivolu
Keyword(s):  
Click Reaction ◽  
Fluorescent Dye ◽  
Side Chains ◽  
Base Pairing ◽  
Triple Bonds

5-Nitroindole oligonucleotides with alkynyl side chains: universal base pairing, triple bond hydration and properties of pyrene “click” adducts

2014 ◽  
Vol 12 (42) ◽  
pp. 8519-8532 ◽  
Author(s):  
Sachin A. Ingale ◽  
Peter Leonard ◽  
Haozhe Yang ◽  
Frank Seela
Keyword(s):  
Triple Bond ◽  
Side Chains ◽  
Base Pairing

Preparation of HA Hydrogel by Click Chemistry

2015 ◽  
Vol 1088 ◽  
pp. 286-289
Author(s):  
Yuan Cui ◽  
Jing Peng Zhang ◽  
Wei Zhang ◽  
Qian Duan
Keyword(s):  
Hyaluronic Acid ◽  
Click Chemistry ◽  
Molecular Design ◽  
Click Reaction ◽  
Side Chains ◽  
H Nmr ◽  
Hydrogel Formation

"Click chemistry" was used in this paper to get a novel hyaluronic acid (HA) hydrogel by modified HA molecules' side chains with azide and alkynyl groups to perform "Click" reaction. The HA hydrogel can be achieved "in situ" injection gel. The properties of the HA hydrogel can be controlled by controlling the amount of alkynyl and azide groups on side chains to achieve controllable HA hydrogel by HA molecular design. The reactant, product and hydrogel were characterized by 1H NMR, FTIR and morphology observation to determine the processes of reaction and can hydrogel formation.

DNA with Branched Internal Side Chains: Synthesis of 5-Tripropargylamine-dU and Conjugation by an Azide-Alkyne Double Click Reaction

ChemBioChem ◽  
2008 ◽  
Vol 9 (14) ◽  
pp. 2305-2316 ◽  
Author(s):  
Venkata Ramana Sirivolu ◽  
Padmaja Chittepu ◽  
Frank Seela
Keyword(s):  
Click Reaction ◽  
Side Chains ◽  
Internal Side

MercuryII-mediated base pairs in DNA: unexpected behavior in metal ion binding and duplex stability induced by 2′-deoxyuridine 5-substituents

2017 ◽  
Vol 15 (4) ◽  
pp. 870-883 ◽  
Author(s):  
Xiurong Guo ◽  
Sachin A. Ingale ◽  
Haozhe Yang ◽  
Yang He ◽  
Frank Seela
Keyword(s):  
Base Pair ◽  
Metal Ion ◽  
Pair Formation ◽  
Ion Binding ◽  
Side Chains ◽  
Mercury Ions ◽  
Metal Ion Binding ◽  
Base Pairs ◽  
Triple Bonds ◽  
Duplex Stability

DNA accepts small substituents at the 5-position of 2′-deoxyuridine residues within mercury ion mediated dU–HgII–dU base pairs, while triple bonds interact with mercury ions and those with space demanding aromatic side chains block metal ion mediated base pair formation.

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