Modification of DNA with Octadiynyl Side Chains: Synthesis, Base Pairing, and Formation of Fluorescent Coumarin Dye Conjugates of Four Nucleobases by the Alkyne−Azide “Click” Reaction

2008 ◽  
Vol 19 (1) ◽  
pp. 211-224 ◽  
Author(s):  
Frank Seela ◽  
Venkata Ramana Sirivolu ◽  
Padmaja Chittepu
Keyword(s):  
Click Reaction ◽  
Side Chains ◽  
Base Pairing ◽  
Coumarin Dye

5-Nitroindole oligonucleotides with alkynyl side chains: universal base pairing, triple bond hydration and properties of pyrene “click” adducts

2014 ◽  
Vol 12 (42) ◽  
pp. 8519-8532 ◽  
Author(s):  
Sachin A. Ingale ◽  
Peter Leonard ◽  
Haozhe Yang ◽  
Frank Seela
Keyword(s):  
Triple Bond ◽  
Side Chains ◽  
Base Pairing

Preparation of HA Hydrogel by Click Chemistry

2015 ◽  
Vol 1088 ◽  
pp. 286-289
Author(s):  
Yuan Cui ◽  
Jing Peng Zhang ◽  
Wei Zhang ◽  
Qian Duan
Keyword(s):  
Hyaluronic Acid ◽  
Click Chemistry ◽  
Molecular Design ◽  
Click Reaction ◽  
Side Chains ◽  
H Nmr ◽  
Hydrogel Formation

"Click chemistry" was used in this paper to get a novel hyaluronic acid (HA) hydrogel by modified HA molecules' side chains with azide and alkynyl groups to perform "Click" reaction. The HA hydrogel can be achieved "in situ" injection gel. The properties of the HA hydrogel can be controlled by controlling the amount of alkynyl and azide groups on side chains to achieve controllable HA hydrogel by HA molecular design. The reactant, product and hydrogel were characterized by 1H NMR, FTIR and morphology observation to determine the processes of reaction and can hydrogel formation.

DNA with Branched Internal Side Chains: Synthesis of 5-Tripropargylamine-dU and Conjugation by an Azide-Alkyne Double Click Reaction

ChemBioChem ◽  
2008 ◽  
Vol 9 (14) ◽  
pp. 2305-2316 ◽  
Author(s):  
Venkata Ramana Sirivolu ◽  
Padmaja Chittepu ◽  
Frank Seela
Keyword(s):  
Click Reaction ◽  
Side Chains ◽  
Internal Side
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