DNA Containing Side Chains with Terminal Triple Bonds: Base-Pair Stability and Functionalization of Alkynylated Pyrimidines and 7-Deazapurines

2006 ◽  
Vol 3 (5) ◽  
pp. 509-514 ◽  
Author(s):  
Frank Seela ◽  
Venkata Ramana Sirivolu
Keyword(s):  
Base Pair ◽  
Side Chains ◽  
Triple Bonds

MercuryII-mediated base pairs in DNA: unexpected behavior in metal ion binding and duplex stability induced by 2′-deoxyuridine 5-substituents

2017 ◽  
Vol 15 (4) ◽  
pp. 870-883 ◽  
Author(s):  
Xiurong Guo ◽  
Sachin A. Ingale ◽  
Haozhe Yang ◽  
Yang He ◽  
Frank Seela
Keyword(s):  
Base Pair ◽  
Metal Ion ◽  
Pair Formation ◽  
Ion Binding ◽  
Side Chains ◽  
Mercury Ions ◽  
Metal Ion Binding ◽  
Base Pairs ◽  
Triple Bonds ◽  
Duplex Stability

DNA accepts small substituents at the 5-position of 2′-deoxyuridine residues within mercury ion mediated dU–HgII–dU base pairs, while triple bonds interact with mercury ions and those with space demanding aromatic side chains block metal ion mediated base pair formation.

scholarly journals Two-component assembly of recognition-encoded oligomers that form stable H-bonded duplexes

2020 ◽  
Vol 11 (2) ◽  
pp. 561-566 ◽  
Author(s):  
Luca Gabrielli ◽  
Diego Núñez-Villanueva ◽  
Christopher A. Hunter
Keyword(s):  
Phosphine Oxide ◽  
Base Pair ◽  
Chloroform Solution ◽  
Side Chains ◽  
Two Component ◽  
Component Assembly

Imine chemistry was used to assemble oligomers displaying phenol and phosphine oxide side chains that selectively base-pair to give duplexes, which are stable in chloroform solution.

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