Differential staining of human and mouse chromosomes in interspecific cell hybrids

MARTIN BOBROW; JANE CROSS

doi:10.1038/251077a0

Differential staining of human and mouse chromosomes in interspecific cell hybrids

Nature ◽

10.1038/251077a0 ◽

1974 ◽

Vol 251 (5470) ◽

pp. 77-79 ◽

Cited By ~ 112

Author(s):

MARTIN BOBROW ◽

JANE CROSS

Keyword(s):

Differential Staining ◽

Cell Hybrids ◽

Interspecific Cell Hybrids ◽

Human And Mouse

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Differential Staining of Parental Chromosomes in Interspecific Cell Hybrids with a Combined Quinacrine and 33258 Hoechst Technique

Proceedings of the Japan Academy ◽

10.2183/pjab1945.51.184 ◽

1975 ◽

Vol 51 (3) ◽

pp. 184-187 ◽

Cited By ~ 45

Author(s):

Michihiro C. YOSHIDA ◽

Tatsuro IKEUCHI ◽

Motomichi SASAKI

Keyword(s):

Differential Staining ◽

Cell Hybrids ◽

Interspecific Cell Hybrids

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Differential staining of interspecific chromosomes in somatic cell hybrids by alkaline Giemsa stain

Somatic Cell Genetics ◽

10.1007/bf01542631 ◽

1976 ◽

Vol 2 (2) ◽

pp. 183-188 ◽

Cited By ~ 50

Author(s):

K. K. Friend ◽

S. Chen ◽

F. H. Ruddle

Keyword(s):

Somatic Cell ◽

Giemsa Stain ◽

Differential Staining ◽

Somatic Cell Hybrids ◽

Cell Hybrids

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Genome instability in interspecific cell hybrids I. Unstable expression of genes in divergent cell hybrids

Journal of Genetics ◽

10.1007/bf02927733 ◽

1988 ◽

Vol 67 (1) ◽

pp. 9-22 ◽

Cited By ~ 6

Author(s):

Jennifer A. Marshall Graves

Keyword(s):

Genome Instability ◽

Cell Hybrids ◽

Expression Of Genes ◽

Interspecific Cell Hybrids

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Genetic counterselective procedure to isolate interspecific cell hybrids containing single human chromosomes: Construction of cell hybrids and recombinant DNA libraries specific for human chromosomes 3 and 4

Somatic Cell and Molecular Genetics ◽

10.1007/bf01560663 ◽

1986 ◽

Vol 12 (2) ◽

pp. 163-174 ◽

Cited By ~ 37

Author(s):

Leon R. Carlock ◽

David Smith ◽

John J. Wasmuth

Keyword(s):

Recombinant Dna ◽

Human Chromosomes ◽

Cell Hybrids ◽

Dna Libraries ◽

Interspecific Cell Hybrids

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Regional mapping of the human No. 1 and X chromosome in interspecific cell hybrids using an X/1 translocation

Cytogenetic and Genome Research ◽

10.1159/000130511 ◽

1975 ◽

Vol 15 (3) ◽

pp. 129-137 ◽

Cited By ~ 1

Author(s):

J. De Wit ◽

D. Bootsma ◽

P.L. Pearson ◽

A. Westerveld

Keyword(s):

X Chromosome ◽

Regional Mapping ◽

Cell Hybrids ◽

Interspecific Cell Hybrids

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Assignment of human gene encoding thymidylate synthase to chromosome 18 using interspecific cell hybrids between thymidylate synthase-Negative mouse mutant cells and human diploid fibroblasts

Somatic Cell and Molecular Genetics ◽

10.1007/bf01534684 ◽

1985 ◽

Vol 11 (3) ◽

pp. 277-283 ◽

Cited By ~ 9

Author(s):

Tada-aki Hori ◽

Dai Ayusawa ◽

Kimiko Shimizu ◽

Hideki Koyama ◽

Takeshi Seno

Keyword(s):

Thymidylate Synthase ◽

Human Gene ◽

Mouse Mutant ◽

Chromosome 18 ◽

Gene Encoding ◽

Diploid Fibroblasts ◽

Human Diploid Fibroblasts ◽

Cell Hybrids ◽

Interspecific Cell Hybrids ◽

Mutant Cells

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Genome Instability in interspecific cell hybrids II. Aminopterin resistance and gene amplification in lines arising from fusions of cells from divergent mammalian species

Journal of Genetics ◽

10.1007/bf02927787 ◽

1988 ◽

Vol 67 (2) ◽

pp. 75-86 ◽

Cited By ~ 3

Author(s):

J. M. Watson ◽

L. M. Mckay ◽

J. A. Marshall Graves

Keyword(s):

Gene Amplification ◽

Genome Instability ◽

Mammalian Species ◽

Cell Hybrids ◽

Interspecific Cell Hybrids

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Assignment of Three Human Genes to Chrosomes (LDH-A to 11, TK to 17, and IDH to 20) and Evidence for Translocation between Human and Mouse Chrosomes in Somatic Cell Hybrids

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.69.2.510 ◽

1972 ◽

Vol 69 (2) ◽

pp. 510-514 ◽

Cited By ~ 78

Author(s):

C. Boone ◽

T.-R. Chen ◽

F. H. Ruddle

Keyword(s):

Somatic Cell ◽

Somatic Cell Hybrids ◽

Cell Hybrids ◽

Human Genes ◽

Human And Mouse

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Genomic instability in interspecific cell hybrids III. Repression of Colcemid resistance in hybrids suggests preferential β-tubulin expression

Journal of Genetics ◽

10.1007/bf02927788 ◽

1988 ◽

Vol 67 (2) ◽

pp. 87-94

Author(s):

Paula A. Zelesco ◽

Jennifer A. Marshall Graves

Keyword(s):

Genomic Instability ◽

Cell Hybrids ◽

Interspecific Cell Hybrids ◽

Β Tubulin

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Some Structural Features of Metaphase Chromosomes of Mice and Men

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100060969 ◽

1967 ◽

Vol 25 ◽

pp. 190-191

Author(s):

Godfrey C. Hoskins ◽

Betty B. Hoskins

Keyword(s):

Electron Microscopy ◽

Electron Micrographs ◽

Structural Features ◽

Metaphase Chromosomes ◽

The Future ◽

Of Mice And Men ◽

Mouse Cells ◽

Human And Mouse

Metaphase chromosomes from human and mouse cells in vitro are isolated by micrurgy, fixed, and placed on grids for electron microscopy. Interpretations of electron micrographs by current methods indicate the following structural features.Chromosomal spindle fibrils about 200Å thick form fascicles about 600Å thick, wrapped by dense spiraling fibrils (DSF) less than 100Å thick as they near the kinomere. Such a fascicle joins the future daughter kinomere of each metaphase chromatid with those of adjacent non-homologous chromatids to either side. Thus, four fascicles (SF, 1-4) attach to each metaphase kinomere (K). It is thought that fascicles extend from the kinomere poleward, fray out to let chromosomal fibrils act as traction fibrils against polar fibrils, then regroup to join the adjacent kinomere.

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