Genomic instability in interspecific cell hybrids III. Repression of Colcemid resistance in hybrids suggests preferential β-tubulin expression

1988 ◽  
Vol 67 (2) ◽  
pp. 87-94
Author(s):  
Paula A. Zelesco ◽  
Jennifer A. Marshall Graves
Keyword(s):  
Genomic Instability ◽  
Cell Hybrids ◽  
Interspecific Cell Hybrids ◽  
Β Tubulin

Genomic instability in mammalian cell hybrids. IV. Is mutation frequency elevated in hybrid cells?

1990 ◽  
Vol 69 (2) ◽  
pp. 79-86
Author(s):  
Robert Center ◽  
Jaclyn M. Watson ◽  
Lynne Mckay ◽  
Rosalia Bruzzese ◽  
Jennifer A. Marshall Graves
Keyword(s):  
Genomic Instability ◽  
Mammalian Cell ◽  
Mutation Frequency ◽  
Hybrid Cells ◽  
Cell Hybrids

Chromosome segregation from cell hybrids. III. Segregation is independent of spindle constitution

Genome ◽  
1987 ◽  
Vol 29 (4) ◽  
pp. 528-531 ◽  
Author(s):  
Paula A. Zelesco ◽  
Jennifer A. Marshall Graves
Keyword(s):  
Somatic Cell ◽  
Key Words ◽  
Chromosome Segregation ◽  
Chinese Hamster ◽  
Somatic Cell Hybrids ◽  
Cell Hybrids ◽  
Mouse Somatic Cell ◽  
Β Tubulin

Hamster β-tubulin (detected as a mutant subunit that confers Colcemid resistance) is either not expressed or is underexpressed in Chinese hamster–mouse somatic cell hybrids. This selectivity of tubulin expression suggests that a uniparental mouse spindle might preferentially engage mouse chromosomes and lead to loss of hamster chromosomes. However, the repression of hamster tubulin was found to have no bearing on the direction of chromosome segregation occurring in eight hybrids studied, some of which segregated predominantly mouse and others hamster chromosomes. Key words: chromosome segregation, cell hybrids, spindle, tubulin.

Regional mapping of the human No. 1 and X chromosome in interspecific cell hybrids using an X/1 translocation

1975 ◽  
Vol 15 (3) ◽  
pp. 129-137 ◽  
Author(s):  
J. De Wit ◽  
D. Bootsma ◽  
P.L. Pearson ◽  
A. Westerveld
Keyword(s):  
X Chromosome ◽  
Regional Mapping ◽  
Cell Hybrids ◽  
Interspecific Cell Hybrids

Genomic instability and radiation mutagenesis

1996 ◽  
Vol 93 ◽  
pp. 157-164 ◽  
Author(s):  
JB Little ◽  
C Li ◽  
H Nagasawa ◽  
T Pfenning ◽  
H Vetrovs
Keyword(s):  
Genomic Instability
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