Genome instability in interspecific cell hybrids I. Unstable expression of genes in divergent cell hybrids

1988 ◽  
Vol 67 (1) ◽  
pp. 9-22 ◽  
Author(s):  
Jennifer A. Marshall Graves
Keyword(s):  
Genome Instability ◽  
Cell Hybrids ◽  
Expression Of Genes ◽  
Interspecific Cell Hybrids

scholarly journals Regulatory network controlling tumor-promoting inflammation in human cancers

2018 ◽  
Author(s):  
Zhe Ji ◽  
Lizhi He ◽  
Aviv Regev ◽  
Kevin Struhl
Keyword(s):  
Cancer Cells ◽  
Regulatory Network ◽  
Feedback Loop ◽  
Genome Instability ◽  
Transcriptional Regulatory Network ◽  
Cellular Transformation ◽  
Inflammatory Index ◽  
Expression Of Genes ◽  
Oncogenic Pathways ◽  
Transcriptional Regulatory

ABSTRACTUsing an inducible, inflammatory model of breast cellular transformation, we describe the transcriptional regulatory network mediated by STAT3, NF-κB, and AP-1 factors on a genomic scale. These regulators form transcriptional complexes that directly regulate the expression of hundreds of genes in oncogenic pathways via a positive feedback loop. This inflammatory feedback loop, which functions to various extents in many types of cancer cells and patient tumors, is the basis for an “inflammation” index that defines cancer types by functional criteria. We identify a network of non-inflammatory genes whose expression is well correlated with the cancer inflammatory index. Conversely, the inflammation index is negatively correlated with expression of genes involved in DNA metabolism, and transformation is associated with genome instability. Inflammatory tumors are preferentially associated with infiltrating immune cells that might be recruited to the site of the tumor via inflammatory molecules produced by the cancer cells.

Regional mapping of the human No. 1 and X chromosome in interspecific cell hybrids using an X/1 translocation

1975 ◽  
Vol 15 (3) ◽  
pp. 129-137 ◽  
Author(s):  
J. De Wit ◽  
D. Bootsma ◽  
P.L. Pearson ◽  
A. Westerveld
Keyword(s):  
X Chromosome ◽  
Regional Mapping ◽  
Cell Hybrids ◽  
Interspecific Cell Hybrids
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